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QuickView for Camk2a;jsessionid=1C7B94D95AD51FED352F5D87747EDBA9;jsessionid=918411A4FFCF60C2775A932895436D3D;jsessionid=252CF8657079E19CC2B2F04D71A70091 (gene)


Gene Symbol:
CAMK2A Homo sapiens Homo sapiens
Full name:
calcium/calmodulin dependent protein kinase II alpha
Synonyms:
CAMKA, MRD53, calcium/calmodulin-dependent protein kinase type II subunit alpha, CaM kinase II alpha subunit, CaM-kinase II alpha chain, CaMK-II alpha subunit, CaMKIINalpha, caM kinase II subunit alpha, caMK-II subunit alpha, calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha, calcium/calmodulin-dependent protein kinase II alpha-B subunit, calcium/calmodulin-dependent protein kinase type II alpha chain
Genomic Location:
Chr 5: 149579248-149649529
Description:
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and de...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Bos taurus Danio rerio Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 5
5q32





GO Molecular Function

guanyl-nucleotide exchange factor activity | GTPase binding | calcium-dependent protein kinase activity | cation binding | enzyme binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | protein serine/threonine kinase activity | Ras GTPase binding | molecular function regulator | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | calcium-dependent protein serine/threonine kinase activity | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | protein homodimerization activity | calmodulin-dependent protein kinase activity | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | Ras guanyl-nucleotide exchange factor activity | protein kinase activity | transferase activity | small GTPase binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | calmodulin binding | metal ion binding | heterocyclic compound binding | glutamate receptor binding | small molecule binding

GO Biological Process

cell morphogenesis | dendritic spine development | guanyl-nucleotide exchange factor activity | response to cytokine | regulation of neurogenesis | neuron projection morphogenesis | regulation of cellular localization | intracellular signal transduction | positive regulation of apoptotic process | regulation of cell development | regulation of localization | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | regulation of mitochondrial membrane permeability involved in apoptotic process | peptidyl-amino acid modification | establishment of localization | response to hormone | regulation of cardiac muscle cell apoptotic process | cell differentiation | defense response | nervous system development | cell part morphogenesis | neurogenesis | calcium-dependent protein kinase activity | generation of neurons | membrane organization | cellular process | regulation of neuron migration | regulation of cell motility | localization | cell projection morphogenesis | metal ion transport | neuron development | regulation of neuronal synaptic plasticity | positive regulation of muscle cell apoptotic process | response to peptide hormone | regulation of cell differentiation | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | interferon-gamma-mediated signaling pathway | cellular response to organonitrogen compound | cellular component organization | MAPK cascade | cellular response to interferon-gamma | response to stimulus | peptidyl-threonine phosphorylation | cell morphogenesis involved in neuron differentiation | signal transduction by protein phosphorylation | response to stress | response to peptide | protein serine/threonine kinase activity | programmed cell death | divalent metal ion transport | response to ischemia | cell cycle G1/S phase transition | apoptotic mitochondrial changes | G-protein coupled receptor signaling pathway | protein modification process | modulation of chemical synaptic transmission | mitochondrion organization | macromolecule modification | cell-cell signaling | molecular function regulator | cell surface receptor signaling pathway involved in cell-cell signaling | regulation of nucleic acid-templated transcription | regulation of neurotransmitter levels | response to nitrogen compound | apoptotic process | cellular response to hormone stimulus | system development | nitrogen compound metabolic process | Wnt signaling pathway | multicellular organism development | cellular response to peptide hormone stimulus | phosphorus metabolic process | peptidyl-threonine autophosphorylation | regulation of gene expression | regulation of mitochondrial membrane permeability | cellular response to peptide | cell cycle | mitochondrial transport | calcium-dependent protein serine/threonine kinase activity | protein autophosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | cytokine-mediated signaling pathway | regulation of cellular component movement | non-canonical Wnt signaling pathway | cellular response to cytokine stimulus | phosphorylation | mitotic cell cycle phase transition | protein phosphorylation | cell morphogenesis involved in differentiation | phosphate-containing compound metabolic process | cellular response to angiotensin | mitochondrial membrane organization | regulation of muscle cell apoptotic process | angiotensin-activated signaling pathway | cell communication | regulation of cellular metabolic process | G1/S transition of mitotic cell cycle | regulation of locomotion | regulation of RNA metabolic process | positive regulation of transport | positive regulation of molecular function | response to angiotensin | neuron differentiation | Wnt signaling pathway, calcium modulating pathway | protein metabolic process | calmodulin-dependent protein kinase activity | response to organic substance | regulation of DNA-binding transcription factor activity | anatomical structure development | mitotic cell cycle | cell surface receptor signaling pathway | cell projection organization | metabolic process | regulation of RNA biosynthetic process | Ras guanyl-nucleotide exchange factor activity | calcium ion transport | regulation of secretion | positive regulation of cell death | immune response | protein kinase activity | neuron projection development | organic substance metabolic process | cell death | positive regulation of ion transport | positive regulation of NF-kappaB transcription factor activity | positive regulation of programmed cell death | response to interferon-gamma | dendrite morphogenesis | positive regulation of cardiac muscle cell apoptotic process | regulation of cell communication | regulation of membrane permeability | signaling | regulation of transcription, DNA-templated | cell development | cellular protein metabolic process | anatomical structure morphogenesis | cation transport | dendrite development | regulation of nervous system development | regulation of developmental process | regulation of ion transport | kinase activity | developmental process | organelle organization | peptidyl-serine phosphorylation | regulation of calcium ion transport | cellular protein modification process | regulation of transport | innate immune response | response to organonitrogen compound | cell cycle phase transition | regulation of synaptic plasticity | ion transport | immune system process | cellular metabolic process | cellular response to organic substance | regulation of cell death | positive regulation of calcium ion transport | signal transduction | regulation of signaling | regulation of neurotransmitter secretion | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

presynaptic membrane | dendritic spine | dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | endocytic vesicle membrane | somatodendritic compartment | organelle membrane | cytoplasmic vesicle | cell | nuclear lumen | synaptic membrane | cytoplasm | intracellular organelle | dendritic tree | presynapse | protein-containing complex | cell projection | neuron spine | postsynapse | nucleoplasm | plasma membrane | vesicle | postsynaptic density | asymmetric synapse | mitochondrion | membrane-bounded organelle | nucleus | organelle | postsynaptic specialization | vesicle membrane | cell periphery | membrane-enclosed lumen | cytosol | intracellular vesicle | calcium- and calmodulin-dependent protein kinase complex | endocytic vesicle | intracellular | cell junction | membrane | cytoplasmic vesicle membrane