QuickView for DHA;jsessionid=F82E3530127D3D6B464348CCE7DDFF0A;jsessionid=1EEFEB7EB77F092F340026AD658BBEA2 (gene)
- Gene Symbol:
- Prop1
Rattus norvegicus - Full name:
- PROP paired-like homeobox 1
- Synonyms:
- homeobox protein prophet of Pit-1, paired like homeodomain factor 1, prophet of Pit1, paired-like homeodomain transcription factor
- Genomic Location:
- Chr 10: 36527112-36529573
- Description:
-
human homolog is a transcription factor that is necessary for activation of Pit1 expression; mutations in human homolog are associated with Combined pituitary hormone deficiency (CPHD)
- Orthologs:
- Homo sapiens , Mus musculus , C. elegans , Macaca mulatta , Bos taurus , Danio rerio , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
sequence-specific DNA binding | beta-catenin binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | enhancer binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding | chromatin binding | enhancer sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | RNA polymerase II regulatory region sequence-specific DNA binding | RNA polymerase II distal enhancer sequence-specific DNA binding | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding | heterocyclic compound binding | protein C-terminus binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | brain development | positive regulation of macromolecule biosynthetic process | somatotropin secreting cell differentiation | cell motility | regulation of programmed cell death | forebrain morphogenesis | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cell differentiation | nervous system development | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | localization | canonical Wnt signaling pathway | negative regulation of nucleic acid-templated transcription | negative regulation of apoptotic process | positive regulation of nitrogen compound metabolic process | diencephalon development | negative regulation of cellular metabolic process | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | pituitary gland development | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | head development | response to stimulus | vasculature development | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding | gland morphogenesis | hypothalamus development | hypophysis morphogenesis | cellular nitrogen compound biosynthetic process | cardiovascular system development | cellular nitrogen compound metabolic process | brain morphogenesis | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | dorsal/ventral pattern formation | adenohypophysis development | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | blood vessel development | regulation of nucleic acid-templated transcription | locomotion | system development | nitrogen compound metabolic process | Wnt signaling pathway | multicellular organism development | cell migration | regulation of gene expression | positive regulation of cellular metabolic process | animal organ morphogenesis | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | endocrine system development | cell communication | regulation of cellular metabolic process | limbic system development | regulation of RNA metabolic process | hypothalamus cell differentiation | diencephalon morphogenesis | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | regionalization | gland development | anatomical structure development | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | forebrain development | gene expression | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | transcription, DNA-templated | signaling | regulation of transcription, DNA-templated | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | developmental process | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | central nervous system development | positive regulation of metabolic process | cellular metabolic process | regulation of cell death | negative regulation of cell death | circulatory system development | signal transduction | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | transcription factor complex | intracellular organelle | protein-containing complex | membrane-bounded organelle | nucleus | organelle | intracellular
