QuickView for DRD2;jsessionid=0D4AC1A950CF1A7D7D450D5A21C8CDF4;jsessionid=1E7F412D4A24504AA8DC228D5E1BE467 (gene)
- Gene Symbol:
- Drd2
Rattus norvegicus - Full name:
- dopamine receptor D2
- Synonyms:
- D(2) dopamine receptor, dopamine receptor 2
- Genomic Location:
- Chr 8: 52641160-52707749
- Description:
-
mediates G-protein coupled signaling; may be involved in movement disorders, schizophrenia, and drug addiction
- Orthologs:
- Homo sapiens , Mus musculus , C. elegans , Macaca mulatta , Bos taurus , Danio rerio , Canis lupus familiaris , Gallus gallus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
neurotransmitter receptor activity | cation binding | transmembrane signaling receptor activity | G-protein coupled receptor activity | dopamine binding | signaling receptor binding | G-protein coupled amine receptor activity | adrenergic receptor activity | signaling receptor activity | identical protein binding | protein heterodimerization activity | ion binding | organic cyclic compound binding | protein binding | protein homodimerization activity | protein dimerization activity | dopamine neurotransmitter receptor activity | drug binding | dopamine neurotransmitter receptor activity, coupled via Gi/Go | glutamate receptor binding | ionotropic glutamate receptor binding
GO Biological Process
negative regulation of G-protein coupled receptor protein signaling pathway | regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | brain development | long-chain fatty acid transport | response to radiation | cell morphogenesis | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | regulation of dephosphorylation | negative regulation of immune system process | branching morphogenesis of a nerve | long-term memory | positive regulation of cellular component organization | cell motility | regulation of neurogenesis | neuron projection morphogenesis | regulation of cellular localization | negative regulation of peptide secretion | intracellular signal transduction | calcium ion transmembrane import into cytosol | regulation of cell development | cytosolic calcium ion transport | regulation of localization | negative regulation of voltage-gated calcium channel activity | catechol-containing compound metabolic process | subpallium development | response to isoquinoline alkaloid | lipid transport | regulation of sodium ion transport | auditory behavior | establishment of localization | regulation of immune system process | neuron migration | negative regulation of cellular process | positive regulation of developmental process | regulation of phosphatase activity | response to metal ion | cell differentiation | nervous system development | response to drug | negative regulation of protein phosphorylation | cellular chemical homeostasis | cell part morphogenesis | negative regulation of dopamine secretion | neurogenesis | positive regulation of phosphate metabolic process | negative regulation of protein secretion | prepulse inhibition | regulation of organelle organization | regulation of peptide hormone secretion | regulation of renal sodium excretion | generation of neurons | positive regulation of protein secretion | response to antibiotic | regulation of neuroblast proliferation | phenol-containing compound metabolic process | regulation of circadian sleep/wake cycle | positive regulation of cellular biosynthetic process | cellular process | secretion | regulation of catecholamine secretion | response to morphine | monocarboxylic acid transport | circadian regulation of gene expression | regulation of cell motility | localization | cellular homeostasis | cell projection morphogenesis | positive regulation of synaptic transmission | regulation of growth hormone secretion | forebrain cell migration | negative regulation of signaling | metal ion transport | visual learning | chemical synaptic transmission | cerebral cortex GABAergic interneuron differentiation | neuron development | walking behavior | regulation of neuronal synaptic plasticity | central nervous system neuron differentiation | synapse assembly | cerebral cortex neuron differentiation | regulation of mitotic nuclear division | anion transport | learning | negative regulation of innate immune response | positive regulation of protein kinase activity | macromolecule localization | negative regulation of secretion | response to hypoxia | regulation of cell cycle | positive regulation of catalytic activity | regulation of multicellular organism growth | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | forebrain neuron differentiation | positive regulation of cell division | diencephalon development | negative regulation of hormone secretion | response to inorganic substance | establishment of localization in cell | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | regulation of behavior | negative regulation of dopamine receptor signaling pathway | regulation of cell differentiation | drinking behavior | positive regulation of cytokinesis | negative regulation of cell motility | regulation of protein kinase B signaling | regulation of immune response | regulation of cellular process | regulation of metabolic process | pituitary gland development | catabolic process | G-protein coupled receptor internalization | regulation of cytosolic calcium ion concentration | neurological system process involved in regulation of systemic arterial blood pressure | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | positive regulation of renal sodium excretion | cellular aromatic compound metabolic process | smooth muscle contraction | negative regulation of response to drug | regulation of urine volume | cellular component organization | calcium ion homeostasis | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | regulation of cell division | head development | G-protein coupled receptor activity | calcium ion transport into cytosol | regulation of peptide secretion | positive regulation of synaptic transmission, dopaminergic | muscle contraction | associative learning | negative regulation of lyase activity | response to stimulus | negative regulation of protein transport | cell morphogenesis involved in neuron differentiation | acid secretion | regulation of long-term synaptic potentiation | regulation of insulin secretion | regulation of excretion | positive regulation of protein metabolic process | response to cocaine | response to stress | adenylate cyclase-activating adrenergic receptor signaling pathway | negative regulation of circadian rhythm | regulation of receptor internalization | regulation of response to drug | regulation of cell proliferation | multicellular organismal homeostasis | positive regulation of neuroblast proliferation | regulation of blood circulation | positive regulation of long-term synaptic potentiation | circadian rhythm | G-protein coupled amine receptor activity | telencephalon cell migration | peristalsis | regulation of heart rate | negative regulation of transporter activity | cellular localization | divalent metal ion transport | response to alcohol | positive regulation of cytokine secretion | regulation of neurotransmitter uptake | rhythmic process | positive regulation of hormone secretion | negative regulation of transport | regulation of protein transport | blood circulation | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | regulation of synapse structure or activity | regulation of peptide transport | modulation of chemical synaptic transmission | positive regulation of multicellular organism growth | response to iron ion | adenohypophysis development | cell-cell signaling | GABAergic neuron differentiation | synaptic transmission, dopaminergic | dopamine metabolic process | negative regulation of calcium ion transmembrane transport | negative regulation of transmembrane transport | activation of protein kinase activity | cell surface receptor signaling pathway involved in cell-cell signaling | metal ion homeostasis | negative regulation of blood pressure | response to ethanol | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | regulation of neurotransmitter levels | locomotion | organic hydroxy compound metabolic process | positive regulation of glial cell-derived neurotrophic factor secretion | response to nitrogen compound | regulation of long-term neuronal synaptic plasticity | central nervous system neuron development | response to light stimulus | response to nicotine | response to inactivity | system development | adrenergic receptor activity | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of urine volume | positive regulation of organelle organization | negative regulation of secretion by cell | Wnt signaling pathway | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of catalytic activity | cell migration | regulation of synaptic transmission, GABAergic | regulation of synaptic transmission, glutamatergic | calcium ion transmembrane transport | regulation of MAPK cascade | learning or memory | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | adenylate cyclase-activating G-protein coupled receptor signaling pathway | regulation of catalytic activity | forebrain neuron development | regulation of phosphorylation | regulation of hormone levels | ion transmembrane transport | regulation of hormone secretion | arachidonic acid secretion | telencephalon development | regulation of receptor-mediated endocytosis | cerebral cortex GABAergic interneuron development | positive regulation of receptor-mediated endocytosis | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | fatty acid transport | axon development | positive regulation of secretion | organic substance transport | nervous system process | regulation of blood pressure | synaptic signaling | adult walking behavior | regulation of stem cell proliferation | regulation of systemic arterial blood pressure | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | response to axon injury | adult locomotory behavior | regulation of dopamine receptor signaling pathway | regulation of dopamine uptake involved in synaptic transmission | behavioral response to ethanol | response to ammonium ion | striatum development | regulation of locomotion involved in locomotory behavior | regulation of synapse organization | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | regulation of cell migration | positive regulation of intracellular signal transduction | vesicle-mediated transport | regulation of cellular component movement | regulation of transcription by RNA polymerase II | pigmentation | organic acid transport | synapse organization | axonogenesis | regulation of synaptic transmission, dopaminergic | behavioral response to cocaine | positive regulation of cell differentiation | second-messenger-mediated signaling | cerebral cortex GABAergic interneuron migration | cognition | negative regulation of ion transmembrane transport | negative regulation of calcium ion transmembrane transporter activity | negative regulation of protein kinase B signaling | locomotory behavior | negative regulation of sequestering of calcium ion | regulation of cellular protein metabolic process | negative regulation of immune response | negative regulation of peptide hormone secretion | organic anion transport | negative regulation of ion transport | negative regulation of adenylate cyclase activity | regulation of calcium ion transmembrane transport | startle response | response to toxic substance | regulation of cyclase activity | regulation of voltage-gated calcium channel activity | response to xenobiotic stimulus | regulation of circadian sleep/wake cycle, sleep | regulation of heart contraction | endocrine system development | cell morphogenesis involved in differentiation | cation homeostasis | negative regulation of synaptic transmission, glutamatergic | autophagy | dopamine receptor signaling pathway | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of cytokinesis | regulation of synapse structural plasticity | positive regulation of response to drug | potassium ion homeostasis | negative regulation of cation channel activity | receptor internalization | negative regulation of calcium ion transport | cyclic-nucleotide-mediated signaling | regulation of protein metabolic process | positive regulation of signal transduction | cellular calcium ion homeostasis | homeostatic process | limbic system development | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | phospholipase C-activating dopamine receptor signaling pathway | regulation of locomotion | regulation of RNA metabolic process | positive regulation of transport | positive regulation of peptide hormone secretion | response to histamine | negative regulation of catecholamine secretion | regulation of dopamine secretion | regulation of mitotic cell cycle | drug metabolic process | negative adaptation of signaling pathway | regulation of potassium ion transport | positive regulation of molecular function | release of sequestered calcium ion into cytosol | regulation of cytokine secretion | neuron differentiation | cation transmembrane transport | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of growth | response to organic substance | gland development | regulation of innate immune response | cellular potassium ion homeostasis | negative regulation of behavior | visual behavior | cAMP-mediated signaling | regulation of protein dephosphorylation | catecholamine metabolic process | regulation of kinase activity | response to wounding | response to mechanical stimulus | import into cell | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway | response to amine | cell surface receptor signaling pathway | positive regulation of neurogenesis | regulation of neural precursor cell proliferation | cell projection organization | metabolic process | lipid localization | positive regulation of cell development | dopamine neurotransmitter receptor activity | regulation of RNA biosynthetic process | regulation of body fluid levels | regulation of vesicle-mediated transport | chemical homeostasis | calcium ion transport | forebrain generation of neurons | endocytosis | regulation of secretion | behavior | neuron projection development | negative regulation of ion transmembrane transporter activity | organic substance metabolic process | regulation of sequestering of calcium ion | positive regulation of neurotransmitter uptake | grooming behavior | neuron-neuron synaptic transmission | animal organ development | positive regulation of ion transport | forebrain development | negative regulation of cellular protein metabolic process | negative regulation of cellular component movement | regulation of protein secretion | positive regulation of G-protein coupled receptor protein signaling pathway | positive regulation of ERK1 and ERK2 cascade | desensitization of G-protein coupled receptor protein signaling pathway | positive regulation of kinase activity | negative regulation of circadian sleep/wake cycle, sleep | ion homeostasis | regulation of phosphate metabolic process | inorganic cation transmembrane transport | response to alkaloid | regulation of ion transmembrane transport | phospholipase C-activating G-protein coupled receptor signaling pathway | renal system process | positive regulation of cytokine production | orbitofrontal cortex development | positive regulation of MAPK cascade | temperature homeostasis | positive regulation of protein transport | regulation of adenylate cyclase activity | memory | adult behavior | negative regulation of protein metabolic process | sensory perception | interneuron migration from the subpallium to the cortex | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | adenylate cyclase-inhibiting dopamine receptor signaling pathway | regulation of cell communication | negative regulation of molecular function | interneuron migration | negative regulation of signal transduction | transmembrane transport | positive regulation of developmental growth | negative regulation of insulin secretion | signaling | feeding behavior | positive regulation of growth | regulation of transcription, DNA-templated | response to organic cyclic compound | cellular monovalent inorganic cation homeostasis | neuromuscular process | cell development | regulation of endocytosis | regulation of developmental growth | sensory perception of chemical stimulus | regulation of transmembrane transporter activity | protein localization | regulation of ion transmembrane transporter activity | positive regulation of phosphorylation | carboxylic acid transport | regulation of cytokine production | morphogenesis of a branching structure | anatomical structure morphogenesis | cation transport | positive regulation of stem cell proliferation | mechanosensory behavior | positive regulation of receptor internalization | regulation of circadian rhythm | regulation of nervous system development | negative regulation of cytosolic calcium ion concentration | regulation of developmental process | regulation of ion transport | receptor-mediated endocytosis | regulation of G-protein coupled receptor protein signaling pathway | positive regulation of neural precursor cell proliferation | regulation of phosphoprotein phosphatase activity | developmental process | positive regulation of cell cycle process | regulation of calcium ion transport | regulation of transport | positive regulation of transcription, DNA-templated | adrenergic receptor signaling pathway | positive regulation of dopamine uptake involved in synaptic transmission | negative regulation of cell proliferation | dopamine neurotransmitter receptor activity, coupled via Gi/Go | receptor metabolic process | regulation of cation channel activity | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | cellular metal ion homeostasis | positive regulation of transcription by RNA polymerase II | negative regulation of synaptic transmission | central nervous system development | response to anesthetic | positive regulation of metabolic process | regulation of synaptic plasticity | regulation of calcium ion transmembrane transporter activity | response to amphetamine | ion transport | cellular metabolic process | regulation of protein localization | regulation of cell death | sensory perception of smell | negative regulation of cell death | positive regulation of growth hormone secretion | divalent inorganic cation homeostasis | negative regulation of locomotion | positive regulation of endocytosis | regulation of cellular component organization | muscle system process | positive regulation of signaling | positive regulation of mitotic nuclear division | signal transduction | regulation of signaling | positive regulation of gene expression | response to auditory stimulus | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
secretory granule | sperm flagellum | dendritic spine | non-motile cilium | exocytic vesicle | integral component of membrane | dendrite | synapse | neuron projection | ciliary membrane | somatodendritic compartment | organelle membrane | cell projection membrane | cytoplasmic vesicle | cell body | cell | neuronal cell body | distal axon | intrinsic component of membrane | transport vesicle membrane | cytoplasm | acrosomal vesicle | intracellular organelle | 9+2 motile cilium | motile cilium | dendritic tree | presynapse | cell projection | secretory vesicle | endomembrane system | neuron spine | postsynapse | plasma membrane | perikaryon | exocytic vesicle membrane | cilium | vesicle | transport vesicle | postsynaptic density | asymmetric synapse | integral component of plasma membrane | synaptic vesicle | membrane-bounded organelle | organelle | postsynaptic specialization | vesicle membrane | axon terminus | cell periphery | axon | neuron projection terminus | synaptic vesicle membrane | intracellular vesicle | endocytic vesicle | intracellular | lateral plasma membrane | membrane | cytoplasmic vesicle membrane | intrinsic component of plasma membrane
