QuickView for DSPP;jsessionid=3CA0FC17325A62D17B7FC16E0FBEFB46;jsessionid=9F891A9E8638B80CB766E018C3969B4E (gene)

Gene Symbol:

Dspp Mus musculus

Full name:

dentin sialophosphoprotein

Synonyms:

Dmp2, Dmp3, Dpp, Dsp, dentin sialophosphoprotein, DMP-3, dentin matrix protein 3

Genomic Location:

Chr 5: 104599731-104609146

Description:

This gene encodes a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins. The encoded preproprotein is secreted by odontoblasts and proteolytically processed to generate two principal proteins of the dentin extracellular matrix of the tooth, dentin sialoprotein and dentin phosphoprotein. These two protein p...

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This gene encodes a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins. The encoded preproprotein is secreted by odontoblasts and proteolytically processed to generate two principal proteins of the dentin extracellular matrix of the tooth, dentin sialoprotein and dentin phosphoprotein. These two protein products may play distinct but related roles in dentin mineralization. Mice lacking the encoded protein exhibit hypomineralization defects in dentin, similar to human dentinogenesis imperfecta.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  D. melanogaster ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AACTTT_UNKNOWN ,  S8_01 ,  GATA1_03 ,  GATA1_04 ,  NFY_Q6 ,  GATA_C ,  NKX25_02 ,  GFI1_01 ,  MEIS1BHOXA9_01 ,  GATA6_01 ,  LHX3_01 ,  IRF1_Q6 ,  NFY_Q6_01 ,  GATA_Q6 ,  T3R_Q6 ,  TAATTA_CHX10_01 ,  GATAAGR_GATA_C ,  YTAATTAA_LHX3_01 ,  GATTGGY_NFY_Q6_01 ,  TAAWWATAG_RSRFC4_Q2 ,  TATAAA_TATA_01

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