QuickView for EDNRB;jsessionid=4A845917245E18415BE4E96F2919D39E;jsessionid=F6748B7DE6484953BDCC3DD3BB7421F8 (gene)

Gene Symbol:

Ednrb Mus musculus

Full name:

endothelin receptor type B

Synonyms:

ET-B, ET-BR, ETR-b, ETb, Sox10m1, endothelin receptor type B, endothelin B receptor, endothelin receptor non-selective type, piebald

Genomic Location:

Chr 14: 104213843-104242913

Description:

This gene encodes a member of the G-protein coupled receptor family. It encodes a receptor for endothelins, peptides that are involved in vasocontriction. The encoded protein activates a phosphatidylinositol-calcium second messenger system and is required for the development of enteric neurons and melanocytes. Gene disruption causes pigmentation an...

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This gene encodes a member of the G-protein coupled receptor family. It encodes a receptor for endothelins, peptides that are involved in vasocontriction. The encoded protein activates a phosphatidylinositol-calcium second messenger system and is required for the development of enteric neurons and melanocytes. Gene disruption causes pigmentation anomalies, deafness, and abnormal dilation of the colon due to defects of neural crest-derived cells. Mutations in this gene are found in the piebald mouse, and mouse models of Hirschsprung's disease and Waardenburg syndrome type 4. Renal collecting duct-specific gene deletion causes sodium retention and hypertension. Alternative splicing results in multiple transcript variants.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris ,  Gallus gallus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  GTGCCTT_MIR506 ,  ATGTTAA_MIR302C ,  TTGCCAA_MIR182 ,  TGCCTTA_MIR124A ,  AAGCACT_MIR520F ,  TGTGTGA_MIR377

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-208 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-499

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