QuickView for EGF;jsessionid=1C3597B16568C30877C71791EF8C3D1D;jsessionid=6ECEB8A1DC0B9F09584634CDA353FC84 (gene)
- Gene Symbol:
- Egf
Mus musculus - Full name:
- epidermal growth factor
- Synonyms:
- AI790464, pro-epidermal growth factor, Pro-epidermal growth factor precursor (EGF)
- Genomic Location:
- Chr 3: 129380496-129458234
- Description:
-
This gene encodes epidermal growth factor (EGF), the founding member of the EGF family of growth factors that are implicated in cell proliferation and differentiation. The encoded protein can localize to the membrane and function in juxtacrine signaling or undergo proteolytic processing to generate a soluble form of the hormone. Mice lacking the en...
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Danio rerio , Canis lupus familiaris , Gallus gallus , Pan troglodytes , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
AACTTT_UNKNOWN , NFKAPPAB_01 , HSF2_01 , NFKB_C , TATA_C , NKX25_01 , TITF1_Q3 , STAT1_03 , STAT4_01 , STAT6_02
| Transcripts Names |
|---|
| NM_010113 |
| XR_001783650 |
| XM_006500990 |
| XM_011240010 |
| XM_011240011 |
| NM_001310737 |
| NM_001329594 |
GO Molecular Function
cation binding | transmembrane signaling receptor activity | signaling receptor binding | molecular function regulator | catalytic activity | signaling receptor activity | ion binding | protein tyrosine kinase activity | protein binding | receptor regulator activity | growth factor activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | receptor ligand activity | protein kinase activity | transferase activity | epidermal growth factor receptor binding | calcium ion binding | Wnt-activated receptor activity | growth factor receptor binding | kinase activity | Wnt-protein binding | metal ion binding
GO Biological Process
positive regulation of hyaluronan biosynthetic process | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | positive regulation of cellular component organization | regulation of cellular localization | intracellular signal transduction | regulation of cholesterol transport | regulation of localization | morphogenesis of an epithelium | regulation of carbohydrate metabolic process | positive regulation of peptidyl-tyrosine phosphorylation | peptidyl-amino acid modification | positive regulation of peptidyl-threonine phosphorylation | positive regulation of developmental process | regulation of MAP kinase activity | positive regulation of fibroblast proliferation | positive regulation of signaling receptor activity | positive regulation of protein catabolic process | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | regulation of organelle organization | positive regulation of cellular component movement | regulation of lipid transport | blood vessel morphogenesis | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | positive regulation of epidermal growth factor-activated receptor activity | regulation of cell motility | epithelial tube morphogenesis | canonical Wnt signaling pathway | regulation of mitotic nuclear division | positive regulation of protein kinase activity | negative regulation of secretion | dorsal/ventral axis specification | regulation of proteolysis | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of canonical Wnt signaling pathway | tissue development | regulation of binding | regulation of cellular process | regulation of metabolic process | epidermal growth factor receptor signaling pathway | positive regulation of cellular protein metabolic process | epithelium development | MAPK cascade | positive regulation of cellular protein catabolic process | regulation of peptide secretion | response to stimulus | vasculature development | regulation of cellular protein localization | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | regulation of cellular protein catabolic process | regulation of receptor internalization | regulation of cell proliferation | tube morphogenesis | positive regulation of proteolysis involved in cellular protein catabolic process | cardiovascular system development | positive regulation of proteolysis | negative regulation of transport | regulation of DNA binding | ERBB signaling pathway | regulation of protein transport | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | protein modification process | regulation of peptide transport | dorsal/ventral pattern formation | macromolecule modification | cell-cell signaling | activation of protein kinase activity | positive regulation of ERBB signaling pathway | molecular function regulator | cell surface receptor signaling pathway involved in cell-cell signaling | blood vessel development | regulation of nucleic acid-templated transcription | regulation of protein tyrosine kinase activity | negative regulation of cholesterol efflux | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | Wnt signaling pathway | multicellular organism development | regulation of MAPK cascade | phosphorus metabolic process | mammary gland development | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of protein localization to cell surface | regulation of phosphorylation | regulation of receptor-mediated endocytosis | positive regulation of receptor-mediated endocytosis | positive regulation of cell cycle | mammary gland lobule development | positive regulation of mitotic cell cycle | regulation of gene expression | Wnt signaling pathway involved in dorsal/ventral axis specification | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | positive regulation of intracellular signal transduction | regulation of cellular component movement | positive regulation of cell migration | regulation of cellular protein metabolic process | angiogenesis | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of DNA biosynthetic process | activation of MAPKK activity | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | regulation of RNA metabolic process | positive regulation of transport | regulation of hyaluronan biosynthetic process | regulation of mitotic cell cycle | protein tyrosine kinase activity | positive regulation of molecular function | activation of MAPK activity | regulation of signaling receptor activity | negative regulation of lipid transport | regulation of epidermal growth factor-activated receptor activity | receptor regulator activity | protein metabolic process | regulation of fibroblast proliferation | regulation of establishment of protein localization | regionalization | axis specification | positive regulation of protein modification process | gland development | tissue morphogenesis | branching morphogenesis of an epithelial tube | regulation of JAK-STAT cascade | regulation of kinase activity | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | growth factor activity | regulation of neural precursor cell proliferation | metabolic process | positive regulation of ubiquitin-dependent protein catabolic process | regulation of protein catabolic process | regulation of RNA biosynthetic process | regulation of vesicle-mediated transport | regulation of secretion | receptor ligand activity | protein kinase activity | organic substance metabolic process | regulation of epidermal growth factor receptor signaling pathway | animal organ development | regulation of protein secretion | positive regulation of kinase activity | regulation of Wnt signaling pathway | regulation of phosphate metabolic process | positive regulation of binding | negative regulation of cholesterol transport | positive regulation of MAPK cascade | morphogenesis of a branching epithelium | positive regulation of canonical Wnt signaling pathway | mammary gland alveolus development | anatomical structure formation involved in morphogenesis | positive regulation of carbohydrate metabolic process | regulation of calcium ion import | regulation of cell communication | Wnt-activated receptor activity | signaling | regulation of transcription, DNA-templated | regulation of ERBB signaling pathway | positive regulation of DNA binding | regulation of endocytosis | positive regulation of phosphorylation | positive regulation of protein tyrosine kinase activity | cellular protein metabolic process | positive regulation of epidermal growth factor receptor signaling pathway | morphogenesis of a branching structure | anatomical structure morphogenesis | positive regulation of MAP kinase activity | positive regulation of receptor internalization | regulation of cerebellar granule cell precursor proliferation | regulation of nervous system development | regulation of developmental process | regulation of ion transport | regulation of cholesterol efflux | positive regulation of neural precursor cell proliferation | positive regulation of DNA metabolic process | kinase activity | developmental process | regulation of DNA biosynthetic process | positive regulation of cell cycle process | regulation of calcium ion transport | cellular protein modification process | tube development | regulation of transport | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | ERK1 and ERK2 cascade | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | positive regulation of cerebellar granule cell precursor proliferation | positive regulation of Wnt signaling pathway | cellular metabolic process | regulation of protein localization | positive regulation of cell motility | circulatory system development | regulation of ubiquitin-dependent protein catabolic process | positive regulation of endocytosis | regulation of cellular component organization | positive regulation of signaling | positive regulation of mitotic nuclear division | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | cell | intrinsic component of membrane | receptor complex | protein-containing complex | plasma membrane | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | membrane
