QuickView for EGR1;jsessionid=7D1D703D6C2B949600F429147F686899;jsessionid=44EFCB45F18486E7C0D2DBC29162B75C;jsessionid=6EF90EB87D5A15897185DBCEDB8409A6 (gene)
- Gene Symbol:
- Egr1
Rattus norvegicus - Full name:
- early growth response 1
- Synonyms:
- Krox-24, NGFI-A, Ngf1, Ngfi, zif-268, early growth response protein 1, EGR-1, nerve growth factor-induced protein A, transcription factor Zif268, zinc finger protein Krox-24
- Genomic Location:
- Chr 18: 27343567-27347352
- Description:
-
activates transcription of the LH receptor gene; may be involved in synaptic plasticity during REM sleep
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Danio rerio , Gallus gallus , Bos taurus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | core promoter binding | cation binding | enzyme binding | nucleic acid binding | hemi-methylated DNA-binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | chromatin binding | RNA polymerase II core promoter sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | promoter-specific chromatin binding | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | histone acetyltransferase binding | zinc ion binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transition metal ion binding | core promoter sequence-specific DNA binding | double-stranded methylated DNA binding | metal ion binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | positive regulation of smooth muscle cell proliferation | response to extracellular stimulus | cellular response to increased oxygen levels | regulation of interleukin-1 beta production | positive regulation of cell proliferation involved in kidney development | response to radiation | cellular response to mycophenolic acid | positive regulation of hormone biosynthetic process | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | response to nutrient levels | long-term memory | response to cytokine | response to interleukin-1 | muscle tissue development | positive regulation of apoptotic process | regulation of localization | cellular response to interleukin-8 | cell proliferation involved in kidney development | response to isoquinoline alkaloid | regulation of programmed cell death | response to hormone | cellular response to hyperoxia | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | cell differentiation | glomerulus development | nervous system development | response to drug | positive regulation of tau-protein kinase activity | neurogenesis | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | response to antibiotic | regulation of neuron death | response to organophosphorus | positive regulation of cellular biosynthetic process | cellular process | positive regulation of glomerulus development | lymphocyte differentiation | regulation of cytokine biosynthetic process | regulation of cell motility | positive regulation of synaptic transmission | negative regulation of signaling | regulation of neuronal synaptic plasticity | immune system development | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | positive regulation of protein kinase activity | response to hypoxia | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of canonical Wnt signaling pathway | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | muscle structure development | skeletal muscle organ development | regulation of cellular process | leukocyte activation | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | gliogenesis | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | urogenital system development | T cell activation | regulation of vasculature development | response to stimulus | positive regulation of interleukin-1 beta production | vasculature development | cellular response to mechanical stimulus | positive regulation of protein metabolic process | positive regulation of glomerular metanephric mesangial cell proliferation | response to cocaine | cellular response to xenobiotic stimulus | cellular response to hypoxia | response to stress | positive regulation of chemokine biosynthetic process | skeletal muscle tissue development | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | ovulation cycle | response to peptide | circadian rhythm | response to glucose | regulation of smooth muscle cell migration | positive regulation of cytokine biosynthetic process | reproduction | response to alcohol | cardiovascular system development | regulation of glomerular mesangial cell proliferation | glomerular mesangial cell proliferation | rhythmic process | cellular nitrogen compound metabolic process | cellular response to toxic substance | response to ischemia | cellular response to organic cyclic compound | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | modulation of chemical synaptic transmission | regulation of steroid biosynthetic process | cellular biosynthetic process | kidney development | regulation of steroid metabolic process | response to mycotoxin | blood vessel development | response to ethanol | regulation of nucleic acid-templated transcription | leukocyte differentiation | response to nitrogen compound | regulation of long-term neuronal synaptic plasticity | response to BMP | cellular response to hormone stimulus | system development | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | cellular response to antibiotic | multicellular organism development | glomerulus vasculature development | cellular response to peptide hormone stimulus | response to purine-containing compound | learning or memory | regulation of tau-protein kinase activity | response to follicle-stimulating hormone | positive regulation of smooth muscle cell migration | regulation of progesterone biosynthetic process | cellular response to insulin stimulus | regulation of catalytic activity | regulation of phosphorylation | regulation of hormone levels | positive regulation of interleukin-1 beta biosynthetic process | wound healing | regulation of gene expression | cellular response to stress | response to lipid | nervous system process | cellular response to peptide | cellular response to gonadotropin stimulus | response to carbon monoxide | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular response to radiation | regulation of ketone biosynthetic process | response to ammonium ion | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | interleukin-1-mediated signaling pathway | cytokine-mediated signaling pathway | regulation of cellular component movement | regulation of transcription by RNA polymerase II | cellular response to alkaloid | cellular response to gamma radiation | cognition | positive regulation of cell migration | cellular response to cytokine stimulus | cell proliferation | biosynthetic process | regulation of hormone metabolic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | glial cell differentiation | response to hyperoxia | positive regulation of neuron death | positive regulation of chemokine production | response to toxic substance | response to xenobiotic stimulus | regulation of protein sumoylation | response to gamma radiation | cellular response to drug | regulation of interleukin-1 production | striated muscle tissue development | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | cellular response to mycotoxin | transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of neuron apoptotic process | positive regulation of interleukin-1 production | metanephros development | response to catecholamine | regulation of protein metabolic process | positive regulation of cell proliferation | response to monosaccharide | regulation of protein phosphorylation | regulation of locomotion | regulation of RNA metabolic process | renal system development | regulation of lipid biosynthetic process | nephron development | lymphocyte activation | positive regulation of molecular function | multicellular organism reproduction | T cell differentiation | response to monoamine | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | positive regulation of protein modification process | response to organic substance | regulation of kinase activity | response to wounding | response to antineoplastic agent | response to mechanical stimulus | positive regulation of metanephric glomerulus development | cellular response to heparin | positive regulation of neuron apoptotic process | response to insulin | anatomical structure development | response to amine | cell surface receptor signaling pathway | metabolic process | regulation of DNA-templated transcription in response to stress | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | cellular response to isoquinoline alkaloid | oligodendrocyte differentiation | behavior | positive regulation of cell death | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | connective tissue development | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | positive regulation of programmed cell death | positive regulation of kinase activity | cellular response to ionizing radiation | regulation of Wnt signaling pathway | cellular response to cAMP | regulation of phosphate metabolic process | response to anticoagulant | response to alkaloid | cellular response to steroid hormone stimulus | transcription, DNA-templated | positive regulation of cytokine production | response to gonadotropin | response to cAMP | cell activation | cellular response to follicle-stimulating hormone stimulus | positive regulation of interleukin-1 biosynthetic process | memory | estrous cycle | BMP signaling pathway | response to norepinephrine | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | positive regulation of phosphorylation | regulation of transcription from RNA polymerase II promoter in response to stress | regulation of cytokine production | cellular macromolecule biosynthetic process | regulation of cellular ketone metabolic process | regulation of developmental process | regulation of transcription from RNA polymerase II promoter in response to hypoxia | developmental process | negative regulation of canonical Wnt signaling pathway | positive regulation of glomerular mesangial cell proliferation | cellular response to interleukin-1 | regulation of chemokine production | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | positive regulation of kidney development | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | response to electrical stimulus | central nervous system development | response to anesthetic | regulation of lipid metabolic process | positive regulation of metabolic process | negative regulation of Wnt signaling pathway | regulation of synaptic plasticity | cellular response to BMP stimulus | response to amphetamine | immune system process | cellular metabolic process | long-term synaptic potentiation | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of cell death | regulation of smooth muscle cell proliferation | positive regulation of cell motility | response to carbohydrate | response to steroid hormone | circulatory system development | skeletal muscle cell differentiation | response to ionizing radiation | muscle organ development | response to heparin | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | regulation of hormone biosynthetic process | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
