QuickView for ERCC2;jsessionid=A230E78121AA7A91C54FDDBD660DDB57;jsessionid=2CC198C4A2215E3ED4B84E3570E05122;jsessionid=083BA68419AE417DF1F16F30F70A606C (gene)
- Gene Symbol:
- RAD3
Saccharomyces cerevisiae - Full name:
- 5' to 3' DNA helicase, involved in nucleotide excision repair and transcription; subunit of RNA polymerase II transcription initiation factor TFIIH; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein
- Synonyms:
- RAD3, REM1, YER171W
- Genomic Location:
- Chr V: 527077-529413
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Bos taurus , Schizosaccharomyces pombe , Danio rerio , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
cofactor binding | cation binding | nucleic acid binding | ribonucleotide binding | ATP-dependent DNA helicase activity | nucleotide binding | hydrolase activity | carbohydrate derivative binding | protein serine/threonine kinase activity | ATPase activity | pyrophosphatase activity | RNA polymerase II CTD heptapeptide repeat kinase activity | catalytic activity | ATP-dependent 5'-3' DNA helicase activity | ATP binding | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | iron-sulfur cluster binding | ATPase activity, coupled | DNA binding | purine nucleotide binding | damaged DNA binding | ATP-dependent helicase activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | DNA helicase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | hydrolase activity, acting on acid anhydrides | protein kinase activity | transferase activity | 4 iron, 4 sulfur cluster binding | purine ribonucleotide binding | adenyl ribonucleotide binding | DNA-dependent ATPase activity | helicase activity | drug binding | transcription factor activity, core RNA polymerase binding | kinase activity | metal ion binding | heterocyclic compound binding | 5'-3' DNA helicase activity | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | response to radiation | positive regulation of macromolecule biosynthetic process | positive regulation of DNA recombination | positive regulation of cellular biosynthetic process | cellular process | regulation of transposition | positive regulation of nitrogen compound metabolic process | DNA geometric change | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | ATP-dependent DNA helicase activity | response to UV | response to stimulus | regulation of DNA recombination | response to stress | cellular nitrogen compound biosynthetic process | protein serine/threonine kinase activity | nucleotide-excision repair, DNA duplex unwinding | cellular nitrogen compound metabolic process | nucleic acid phosphodiester bond hydrolysis | positive regulation of RNA biosynthetic process | protein modification process | RNA polymerase II CTD heptapeptide repeat kinase activity | cellular biosynthetic process | macromolecule modification | DNA repair | regulation of nucleic acid-templated transcription | ATP-dependent 5'-3' DNA helicase activity | response to light stimulus | nitrogen compound metabolic process | phosphorus metabolic process | cellular response to DNA damage stimulus | regulation of gene expression | cellular response to stress | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | response to oxidative stress | positive regulation of mitotic recombination | phosphorylation of RNA polymerase II C-terminal domain | biosynthetic process | aromatic compound biosynthetic process | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | DNA duplex unwinding | regulation of cellular metabolic process | regulation of RNA metabolic process | DNA helicase activity | protein metabolic process | DNA metabolic process | nucleotide-excision repair, DNA incision | metabolic process | nucleotide-excision repair | regulation of RNA biosynthetic process | regulation of mitotic recombination | nucleobase-containing compound metabolic process | protein kinase activity | organic substance metabolic process | gene expression | regulation of transposition, RNA-mediated | transcription, DNA-templated | regulation of transcription, DNA-templated | cellular protein metabolic process | cellular macromolecule biosynthetic process | positive regulation of DNA metabolic process | transcription factor activity, core RNA polymerase binding | kinase activity | organelle organization | cellular protein modification process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | DNA conformation change | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | cellular metabolic process | 5'-3' DNA helicase activity | positive regulation of gene expression | macromolecule metabolic process
GO Cellular Component
nuclear transcription factor complex | intracellular membrane-bounded organelle | catalytic complex | RNA polymerase II transcription factor complex | DNA repair complex | protein kinase complex | cell | nuclear lumen | transcription factor complex | intracellular organelle | carboxy-terminal domain protein kinase complex | protein-containing complex | nucleotide-excision repair factor 3 complex | nucleotide-excision repair complex | nucleoplasm | transferase complex | serine/threonine protein kinase complex | membrane-bounded organelle | holo TFIIH complex | nucleus | organelle | nuclear DNA-directed RNA polymerase complex | RNA polymerase complex | membrane-enclosed lumen | core TFIIH complex | intracellular | RNA polymerase II, holoenzyme
