Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward Export SNPs

QuickView for ERK1;jsessionid=EDE9B88CDD801A91A783B036B24EF898;jsessionid=0F75D725ACEDBB856C16242F0F6D8C41 (gene)


Gene Symbol:
MAPK3 Homo sapiens Homo sapiens
Full name:
mitogen-activated protein kinase 3
Synonyms:
ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK, mitogen-activated protein kinase 3, MAP kinase isoform p44, MAPK 1, extracellular signal-regulated kinase 1, extracellular signal-related kinase 1, insulin-stimulated MAP2 kinase, microtubule-associated protein 2 kinase
Genomic Location:
Chr 16: 30032927-30042131
Description:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is act...
Orthologs:
Mus musculus Rattus norvegicus Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Danio rerio Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 16
16p11.2





GO Molecular Function

protein phosphorylated amino acid binding | enzyme binding | phosphotyrosine residue binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | identical protein binding | scaffold protein binding | MAP kinase activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | phosphoprotein binding | protein binding | MAP kinase kinase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | protein serine/threonine/tyrosine kinase activity | drug binding | kinase activity | phosphatase binding | heterocyclic compound binding | small molecule binding

GO Biological Process

positive regulation of immune response | positive regulation of cyclase activity | RNA metabolic process | response to extracellular stimulus | regulation of leukocyte chemotaxis | regulation of telomere maintenance via telomerase | regulation of ERK1 and ERK2 cascade | DNA-templated transcription, initiation | cell morphogenesis | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | response to nutrient levels | response to cytokine | response to interleukin-1 | positive regulation of cellular component organization | neuron projection morphogenesis | immune response-regulating signaling pathway | response to lipopolysaccharide | regulation of cellular localization | intracellular signal transduction | regulation of localization | positive regulation of telomere capping | peptidyl-amino acid modification | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of autophagy | regulation of immune system process | response to dopamine | transcription initiation from RNA polymerase I promoter | regulation of MAP kinase activity | response to metal ion | cellular response to tumor necrosis factor | cell differentiation | immune response-activating cell surface receptor signaling pathway | respiratory tube development | nervous system development | cellular response to extracellular stimulus | response to drug | cellular chemical homeostasis | cell part morphogenesis | neurogenesis | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | regulation of organelle organization | positive regulation of cellular component movement | generation of neurons | positive regulation of protein secretion | mesenchyme development | positive regulation of cellular biosynthetic process | cellular process | Fc-gamma receptor signaling pathway involved in phagocytosis | response to exogenous dsRNA | positive regulation of macrophage migration | regulation of cell motility | localization | cellular homeostasis | cell projection morphogenesis | positive regulation of immune effector process | neuron development | immune system development | positive regulation of telomerase activity | positive regulation of protein kinase activity | regulation of histone modification | hemostasis | regulation of chemotaxis | axon guidance | cellular response to starvation | regulation of proteolysis | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | response to inorganic substance | tissue development | regulation of binding | interspecies interaction between organisms | caveolin-mediated endocytosis | DNA damage induced protein phosphorylation | peptidyl-tyrosine autophosphorylation | regulation of immune response | regulation of cellular process | cellular response to lipid | regulation of metabolic process | gliogenesis | cellular response to molecule of bacterial origin | organic cyclic compound metabolic process | positive regulation of translation | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | cellular component organization | cellular lipid metabolic process | MAPK cascade | cellular response to metal ion | head development | regulation of telomere capping | thyroid gland development | regulation of peptide secretion | response to stimulus | thymus development | outer ear morphogenesis | cell morphogenesis involved in neuron differentiation | cellular response to mechanical stimulus | mesenchymal cell development | monocarboxylic acid metabolic process | respiratory system development | cellular response to fibroblast growth factor stimulus | regulation of cellular response to heat | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of peptidase activity | signal transduction by protein phosphorylation | cardiac neural crest cell development involved in heart development | response to stress | neuron projection guidance | transcription by RNA polymerase I | cellular nitrogen compound biosynthetic process | posttranscriptional regulation of gene expression | response to starvation | protein serine/threonine kinase activity | programmed cell death | cellular response to inorganic substance | positive regulation of cytokine secretion | cellular response to cadmium ion | positive regulation of proteolysis | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | immune response-activating signal transduction | regulation of macroautophagy | cellular response to organic cyclic compound | regulation of protein transport | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | cellular component assembly | protein modification process | cartilage development | regulation of peptide transport | cellular biosynthetic process | embryo development | macromolecule modification | negative regulation of apolipoprotein binding | trachea morphogenesis | activation of protein kinase activity | positive regulation of telomere maintenance via telomere lengthening | regulation of intracellular transport | stress-activated protein kinase signaling cascade | blood coagulation | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | regulation of cellular response to stress | locomotion | response to nitrogen compound | response to BMP | apoptotic process | regulation of histone phosphorylation | response to external biotic stimulus | system development | cellular response to nutrient levels | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | multicellular organism development | regulation of peptidase activity | regulation of MAPK cascade | phosphorus metabolic process | response to dsRNA | cellular response to DNA damage stimulus | regulation of telomere maintenance | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lipid metabolic process | cellular response to oxidative stress | regulation of granulocyte chemotaxis | regulation of phosphorylation | fibroblast growth factor receptor signaling pathway | regulation of ossification | wound healing | Fc-gamma receptor signaling pathway | positive regulation of chromosome organization | cellular response to amino acid starvation | cellular response to ammonium ion | regulation of gene expression | positive regulation of chemotaxis | platelet activation | axon development | positive regulation of secretion | cellular response to stress | response to lipid | nervous system process | cell cycle | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of telomerase activity | cellular ion homeostasis | animal organ morphogenesis | response to ammonium ion | protein autophosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | interleukin-1-mediated signaling pathway | small molecule metabolic process | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | cardiocyte differentiation | vesicle-mediated transport | regulation of cellular component movement | regulation of transcription by RNA polymerase II | response to oxidative stress | axonogenesis | negative regulation of binding | positive regulation of hydrolase activity | Fc-epsilon receptor signaling pathway | stem cell differentiation | positive regulation of cell migration | cellular response to cytokine stimulus | biosynthetic process | response to cadmium ion | stress-activated MAPK cascade | sensory perception of pain | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | MAP kinase activity | glial cell differentiation | phosphorylation | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | response to toxic substance | positive regulation of telomere maintenance via telomerase | regulation of cyclase activity | endocrine system development | protein phosphorylation | cell morphogenesis involved in differentiation | positive regulation of macrophage chemotaxis | cation homeostasis | regulation of leukocyte migration | phosphate-containing compound metabolic process | sensory organ development | trachea formation | cellular response to drug | regulation of telomere maintenance via telomere lengthening | response to bacterium | animal organ formation | cellular cation homeostasis | cell communication | negative regulation of protein binding | regulation of cellular metabolic process | regulation of protein kinase activity | transmembrane receptor protein serine/threonine kinase signaling pathway | positive regulation of leukocyte chemotaxis | positive regulation of DNA biosynthetic process | response to catecholamine | astrocyte differentiation | regulation of cytokine production involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | heart development | homeostatic process | regulation of Golgi inheritance | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of locomotion | regulation of RNA metabolic process | positive regulation of protein acetylation | lipopolysaccharide-mediated signaling pathway | positive regulation of transport | viral process | coagulation | long-chain fatty acid metabolic process | embryonic morphogenesis | carboxylic acid metabolic process | positive regulation of molecular function | regulation of cytokine secretion | neuron differentiation | activation of MAPK activity | embryonic organ morphogenesis | response to monoamine | protein-containing complex assembly | activation of immune response | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | gland development | regulation of pH | positive regulation of xenophagy | regulation of kinase activity | response to wounding | response to mechanical stimulus | import into cell | MAP kinase kinase activity | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | positive regulation of peptidyl-lysine acetylation | anatomical structure development | cell surface receptor signaling pathway | cell projection organization | metabolic process | mesenchymal cell differentiation | regulation of RNA biosynthetic process | regulation of body fluid levels | embryonic organ development | regulation of cytokine secretion involved in immune response | positive regulation of cytokine production involved in immune response | ear development | regulation of vesicle-mediated transport | chemical homeostasis | endocytosis | regulation of secretion | trachea development | nucleobase-containing compound metabolic process | protein kinase activity | cellular response to reactive oxygen species | neuron projection development | organic substance metabolic process | connective tissue development | cell death | animal organ development | positive regulation of histone modification | response to reactive oxygen species | gene expression | regulation of protein secretion | positive regulation of leukocyte migration | positive regulation of ERK1 and ERK2 cascade | positive regulation of kinase activity | ion homeostasis | regulation of phosphate metabolic process | positive regulation of cytokine secretion involved in immune response | regulation of chromosome organization | Bergmann glial cell differentiation | fatty acid metabolic process | positive regulation of autophagy | transcription, DNA-templated | positive regulation of cytokine production | regulation of cellular pH | positive regulation of macroautophagy | cell activation | positive regulation of MAPK cascade | lung development | response to epidermal growth factor | stem cell development | positive regulation of protein transport | anatomical structure formation involved in morphogenesis | sensory perception | icosanoid metabolic process | BMP signaling pathway | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of molecular function | signaling | regulation of transcription, DNA-templated | regulation of protein binding | response to organic cyclic compound | cellular monovalent inorganic cation homeostasis | cell development | organic acid metabolic process | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | positive regulation of MAP kinase activity | protein serine/threonine/tyrosine kinase activity | response to biotic stimulus | positive regulation of telomere maintenance | positive regulation of DNA metabolic process | kinase activity | developmental process | regulation of DNA biosynthetic process | Fc receptor signaling pathway | cellular response to interleukin-1 | peptidyl-serine phosphorylation | cellular protein modification process | Fc receptor mediated stimulatory signaling pathway | regulation of histone acetylation | tube development | positive regulation of histone acetylation | regulation of transport | positive regulation of transcription, DNA-templated | response to fibroblast growth factor | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | neural crest cell differentiation | lung morphogenesis | ERK1 and ERK2 cascade | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | response to amino acid starvation | regulation of macrophage chemotaxis | cellular response to dopamine | central nervous system development | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | cellular response to BMP stimulus | skeletal system development | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | response to tumor necrosis factor | cellular response to organic substance | regulation of protein localization | positive regulation of cell motility | regulation of translation | positive regulation of histone phosphorylation | positive regulation of metallopeptidase activity | circulatory system development | arachidonic acid metabolic process | regulation of early endosome to late endosome transport | chemotaxis | ear morphogenesis | neural crest cell development | phagocytosis | regulation of cellular component organization | regulation of Golgi organization | regulation of cytoskeleton organization | response to other organism | positive regulation of signaling | cellular response to catecholamine stimulus | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | positive regulation of gene expression | cellular response to growth factor stimulus | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process | regulation of chromatin organization | face development | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | late endosome | adherens junction | focal adhesion | cytoplasmic vesicle | cell | nuclear lumen | cytoplasm | cell-substrate junction | intracellular organelle | membrane microdomain | Golgi apparatus | pseudopodium | protein-containing complex | cell projection | endomembrane system | nucleoplasm | plasma membrane | nuclear envelope | membrane raft | vesicle | mitochondrion | endosome | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | early endosome | cell-substrate adherens junction | plasma membrane raft | cytosol | intracellular vesicle | cytoskeleton | intracellular | cell junction | caveola | membrane