QuickView for ESR1;jsessionid=1865E83F66116AE7E5B5B4667EF71FC8;jsessionid=CA6A8280E5EC59B1418E928CCF6992D3 (gene)

Gene Symbol:

Esr1 Mus musculus

Full name:

estrogen receptor 1 (alpha)

Synonyms:

ER, ER-alpha, ERa, ERalpha, ESR, Estr, Estra, Nr3a1, estrogen receptor, C-terminally-truncated estrogen receptor alpha product-4, C-terminally-truncated estrogen receptor alpha product-5, C-terminally-truncated estrogen receptor alpha product-6, C-terminally-truncated estrogen receptor alpha product-7, estradiol receptor, nuclear receptor subfamily 3 group A member 1

Genomic Location:

Chr 10: 5342780-5734495

Description:

This gene encodes an estrogen receptor, a member of the nuclear hormone family of intracellular receptors. The encoded protein, activated by the sex hormone estrogen, is a transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Estrogen and its receptors are essential for sexual ...

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This gene encodes an estrogen receptor, a member of the nuclear hormone family of intracellular receptors. The encoded protein, activated by the sex hormone estrogen, is a transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Similar genes in human have been implicated in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in multiple transcript variants.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AAANWWTGC_UNKNOWN ,  AACTTT_UNKNOWN ,  RSRFC4_01 ,  IRF1_01 ,  IRF2_01 ,  GATA3_01 ,  CEBPA_01 ,  CEBPB_02 ,  ARGGGTTAA_UNKNOWN ,  AP4_Q5 ,  GR_Q6 ,  MEF2_02 ,  MEF2_03 ,  ISRE_01 ,  MMEF2_Q6 ,  RSRFC4_Q2 ,  IRF7_01 ,  NCX_01 ,  NKX22_01 ,  AFP1_Q6 ,  ICSBP_Q6 ,  SREBP1_Q6 ,  IRF_Q6 ,  TTF1_Q6 ,  CEBP_Q2_01 ,  MEF2_Q6_01 ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  TGCACTG_MIR148A_MIR152_MIR148B ,  TTGCACT_MIR130A_MIR301_MIR130B ,  AAAGGGA_MIR204_MIR211 ,  ATGTAGC_MIR221_MIR222 ,  TTTGCAC_MIR19A_MIR19B ,  GCACCTT_MIR18A_MIR18B ,  AGGGCAG_MIR18A ,  ATAGGAA_MIR202 ,  GGCAGCT_MIR22 ,  GACAATC_MIR219 ,  AAGCACT_MIR520F ,  TGCTTTG_MIR330 ,  AAGGGAT_MIR188 ,  RTTTNNNYTGGM_UNKNOWN ,  TTCYRGAA_UNKNOWN ,  TGANTCA_AP1_C ,  CAGCTG_AP4_Q5 ,  CAGGTG_E12_Q6 ,  TGATTTRY_GFI1_01 ,  TGTTTGY_HNF3_Q6 ,  STTTCRNTTT_IRF_Q6 ,  GGGAGGRR_MAZ_Q6 ,  TGCCAAR_NF1_Q6 ,  TGGAAA_NFAT_Q4_01 ,  CTAWWWATA_RSRFC4_Q2 ,  TAAWWATAG_RSRFC4_Q2 ,  TGANNYRGCA_TCF11MAFG_01 ,  WGGAATGY_TEF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-18 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-361 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-188 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-496

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