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QuickView for ESR1;jsessionid=1865E83F66116AE7E5B5B4667EF71FC8;jsessionid=3E2CE320E4E5800D24679C031F78E2F4 (gene)


Gene Symbol:
Esr1 Rattus norvegicus Rattus norvegicus
Full name:
estrogen receptor 1
Synonyms:
ER-alpha, Esr, RNESTROR, estrogen receptor, C-terminally-truncated estrogen receptor alpha product-1, Er alpha, estradiol receptor, estrogen receptor 1 (alpha), estrogen receptor alpha c-terminus splice variant 1-2, estrogen receptor alpha i45aL, estrogen receptor alpha i45aS, estrogen receptor alpha i45c, estrogen receptor alpha i56a, estrogen receptor alpha i56b, estrogen receptor alpha i56c, estrogen receptor alpha i56dL, estrogen receptor alpha i56dS, estrogen receptor alpha i56e, estrogen receptor alpha variant delta 4, estrogen receptor protein, nuclear receptor subfamily 3 group A member 1, truncated estrogen receptor product-2, trunctaed estrogen receptor product-1
Genomic Location:
Chr 1: 35523680-35759881
Description:
acts as a transcriptional activator when bound to estrogen; may play a role in myocardial regulation
Orthologs:
Homo sapiens Mus musculus Macaca mulatta Danio rerio Gallus gallus Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
AAANWWTGC_UNKNOWN AACTTT_UNKNOWN RSRFC4_01 IRF1_01 IRF2_01 GATA3_01 CEBPA_01 CEBPB_02 ARGGGTTAA_UNKNOWN AP4_Q5
miRNA binding sites
(Source: TargetScan):





GO Molecular Function

sequence-specific DNA binding | beta-catenin binding | phosphatidylinositol 3-kinase binding | kinase binding | type 1 metabotropic glutamate receptor binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | nuclear receptor activity | cation binding | hormone receptor binding | transcription factor activity, direct ligand regulated sequence-specific DNA binding | protein kinase binding | proximal promoter sequence-specific DNA binding | G-protein coupled glutamate receptor binding | enzyme binding | nucleic acid binding | protein-containing complex binding | lipid binding | estrogen receptor binding | signaling receptor binding | transcription coactivator binding | TFIIB-class transcription factor binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | steroid hormone receptor activity | chromatin binding | ATPase binding | RNA polymerase II regulatory region DNA binding | phosphatidylinositol 3-kinase regulatory subunit binding | DNA binding | signaling receptor activity | sequence-specific double-stranded DNA binding | promoter-specific chromatin binding | identical protein binding | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | nuclear hormone receptor binding | ion binding | organic cyclic compound binding | hormone binding | transcription regulatory region sequence-specific DNA binding | estrogen receptor activity | protein binding | zinc ion binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | TBP-class protein binding | RNA polymerase II transcription factor binding | G-protein coupled receptor binding | estrogen response element binding | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transition metal ion binding | steroid hormone receptor binding | steroid binding | transcription cofactor binding | metal ion binding | basal RNA polymerase II transcription machinery binding | heterocyclic compound binding | glutamate receptor binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | regulation of ERK1 and ERK2 cascade | positive regulation of macromolecule biosynthetic process | positive regulation of cellular component organization | developmental process involved in reproduction | ovarian follicle development | regulation of localization | mammary gland duct morphogenesis | prostate gland growth | morphogenesis of an epithelium | positive regulation of DNA-binding transcription factor activity | gonad development | regulation of programmed cell death | female gonad development | regulation of immune system process | response to hormone | regulation of nitric oxide biosynthetic process | negative regulation of neuron death | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | epithelial cell proliferation involved in mammary gland duct elongation | negative regulation of RNA biosynthetic process | bone development | cell differentiation | positive regulation of epithelial cell proliferation | positive regulation of fibroblast proliferation | maternal placenta development | organ growth | cellular chemical homeostasis | negative regulation of gene silencing by RNA | positive regulation of phosphate metabolic process | hormone-mediated signaling pathway | regulation of neuron death | positive regulation of cellular biosynthetic process | regulation of transcription initiation from RNA polymerase II promoter | cellular process | regulation of branching involved in prostate gland morphogenesis | regulation of production of miRNAs involved in gene silencing by miRNA | nuclear receptor activity | regulation of glucose import | localization | cellular homeostasis | epithelial tube morphogenesis | negative regulation of signaling | developmental growth | positive regulation of reactive oxygen species metabolic process | reproductive system development | response to estradiol | female pregnancy | positive regulation of nitric-oxide synthase activity | transcription factor activity, direct ligand regulated sequence-specific DNA binding | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | macromolecule localization | positive regulation of oxidoreductase activity | Sertoli cell differentiation | osteoblast development | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | regulation of immune response | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | regulation of protein complex assembly | regulation of cytosolic calcium ion concentration | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | regulation of gene silencing by miRNA | baculum development | prostate gland epithelium morphogenesis | calcium ion homeostasis | urogenital system development | mammary gland morphogenesis | development of primary sexual characteristics | response to stimulus | positive regulation of nitric oxide metabolic process | positive regulation of protein metabolic process | gland morphogenesis | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | ovulation cycle | Sertoli cell proliferation | tube morphogenesis | negative regulation of glucose transmembrane transport | epithelial cell development | development of primary female sexual characteristics | reproduction | cellular localization | androgen metabolic process | rhythmic process | regulation of gene silencing | cellular nitrogen compound metabolic process | positive regulation of lipase activity | axis elongation | negative regulation of transport | cellular response to organic cyclic compound | G-protein coupled receptor signaling pathway | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | steroid hormone receptor activity | steroid hormone mediated signaling pathway | cellular biosynthetic process | regulation of triglyceride metabolic process | regulation of morphogenesis of a branching structure | negative regulation of transmembrane transport | positive regulation of ERBB signaling pathway | metal ion homeostasis | regulation of nucleic acid-templated transcription | regulation of neurotransmitter levels | positive regulation of monooxygenase activity | positive regulation of phospholipase C activity | cellular response to hormone stimulus | positive regulation of reactive oxygen species biosynthetic process | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | multicellular organism development | regulation of toll-like receptor signaling pathway | regulation of MAPK cascade | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly | mammary gland development | antral ovarian follicle growth | regulation of catalytic activity | lipid metabolic process | negative regulation of glucose import | vagina development | regulation of phosphorylation | regulation of hormone levels | regulation of nitric-oxide synthase activity | mammary gland lobule development | regulation of gene expression | negative regulation of gene silencing by miRNA | response to lipid | branching involved in prostate gland morphogenesis | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | animal organ morphogenesis | negative regulation of smooth muscle cell proliferation | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | intracellular estrogen receptor signaling pathway | negative regulation of DNA-binding transcription factor activity | positive regulation of intracellular signal transduction | positive regulation of protein complex assembly | regulation of transcription by RNA polymerase II | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | protein localization to organelle | positive regulation of hydrolase activity | stem cell differentiation | cell proliferation | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | regulation of RNA polymerase II transcriptional preinitiation complex assembly | mammary gland epithelial cell proliferation | regulation of phospholipase activity | cation homeostasis | ovulation cycle process | protein localization to chromatin | response to estrogen | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | female genitalia development | cellular response to estrogen stimulus | regulation of neuron apoptotic process | regulation of protein metabolic process | positive regulation of signal transduction | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of RNA metabolic process | genitalia development | estrogen receptor activity | decidualization | regulation of phospholipase C activity | positive regulation of molecular function | negative regulation of gene silencing | multicellular organism reproduction | maternal process involved in female pregnancy | development of primary male sexual characteristics | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | regulation of fibroblast proliferation | DNA-binding transcription factor activity | positive regulation of protein modification process | response to organic substance | gland development | regulation of innate immune response | tissue morphogenesis | branching morphogenesis of an epithelial tube | epithelial cell proliferation | male sex differentiation | regulation of animal organ morphogenesis | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | Sertoli cell development | anatomical structure development | developmental growth involved in morphogenesis | branch elongation of an epithelium | negative regulation of lipid metabolic process | metabolic process | positive regulation of DNA-templated transcription, initiation | negative regulation of I-kappaB kinase/NF-kappaB signaling | regulation of RNA biosynthetic process | prostate epithelial cord elongation | negative regulation of transcription, DNA-templated | male gonad development | cellular protein localization | chemical homeostasis | regulation of gene silencing by RNA | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | positive regulation of cellular component biogenesis | organic substance metabolic process | regulation of epidermal growth factor receptor signaling pathway | negative regulation of biosynthetic process | negative regulation of gene expression | regulation of glucose transmembrane transport | animal organ development | gene expression | mammary gland branching involved in pregnancy | positive regulation of ERK1 and ERK2 cascade | ion homeostasis | regulation of phosphate metabolic process | mammary gland epithelium development | cellular response to steroid hormone stimulus | prostate gland morphogenesis | phospholipase C-activating G-protein coupled receptor signaling pathway | transcription, DNA-templated | positive regulation of phospholipase activity | positive regulation of MAPK cascade | intracellular receptor signaling pathway | morphogenesis of a branching epithelium | regulation of reactive oxygen species biosynthetic process | mammary gland alveolus development | uterus development | cellular response to estradiol stimulus | steroid metabolic process | prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | regulation of oxidoreductase activity | response to organic cyclic compound | cell development | regulation of ERBB signaling pathway | protein localization | regulation of epithelial cell proliferation | regulation of production of small RNA involved in gene silencing by RNA | positive regulation of phosphorylation | positive regulation of epidermal growth factor receptor signaling pathway | hormone metabolic process | morphogenesis of a branching structure | anatomical structure morphogenesis | prostate gland development | cellular macromolecule localization | cellular macromolecule biosynthetic process | regulation of DNA-templated transcription, initiation | reproductive structure development | regulation of developmental process | developmental process | intracellular steroid hormone receptor signaling pathway | branch elongation involved in mammary gland duct branching | negative regulation of transcription by RNA polymerase II | tube development | regulation of transport | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | negative regulation of cell proliferation | positive regulation of nucleic acid-templated transcription | cellular metal ion homeostasis | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | negative regulation of triglyceride metabolic process | heterocycle metabolic process | positive regulation of nitric oxide biosynthetic process | regulation of lipid metabolic process | positive regulation of metabolic process | ossification | osteoblast differentiation | skeletal system development | cellular metabolic process | placenta development | female sex differentiation | cellular response to organic substance | regulation of cell death | sex differentiation | regulation of smooth muscle cell proliferation | response to steroid hormone | negative regulation of cell death | regulation of inflammatory response | branching involved in mammary gland duct morphogenesis | divalent inorganic cation homeostasis | regulation of I-kappaB kinase/NF-kappaB signaling | regulation of cellular component organization | positive regulation of transcription initiation from RNA polymerase II promoter | positive regulation of signaling | protein localization to chromosome | signal transduction | regulation of signaling | positive regulation of gene expression | negative regulation of production of miRNAs involved in gene silencing by miRNA | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | sarcolemma | synapse | neuron projection | somatodendritic compartment | cell body | cell | nuclear lumen | neuronal cell body | distal axon | terminal bouton | cytoplasm | intracellular organelle | transcriptional preinitiation complex | presynapse | Golgi apparatus | protein-containing complex | cell projection | endomembrane system | protein-DNA complex | plasma membrane | perikaryon | chromatin | nuclear chromosome | perinuclear region of cytoplasm | mitochondrion | T-tubule | membrane-bounded organelle | nucleus | organelle | axon terminus | cell periphery | axon | membrane-enclosed lumen | nuclear chromatin | neuron projection terminus | transcriptionally active chromatin | intracellular | membrane