QuickView for EcR;jsessionid=BB78354AC07BC482EDBF0E364213B78F;jsessionid=18798F92D84F45B083E77BB8CF36C161 (gene)
- Gene Symbol:
- NR1H3
Homo sapiens - Full name:
- nuclear receptor subfamily 1 group H member 3
- Synonyms:
- LXR-a, LXRA, RLD-1, oxysterols receptor LXR-alpha, liver X nuclear receptor alpha variant 1
- Genomic Location:
- Chr 11: 47237309-47246972
- Description:
-
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
11p11.2
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | nuclear receptor activity | cation binding | transcription factor activity, direct ligand regulated sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | lipid binding | sterol binding | steroid hormone receptor activity | alcohol binding | RNA polymerase II regulatory region DNA binding | DNA binding | signaling receptor activity | sequence-specific double-stranded DNA binding | ion binding | organic cyclic compound binding | cholesterol binding | transcription coactivator activity | transcription regulatory region sequence-specific DNA binding | protein binding | zinc ion binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | DNA-binding transcription factor activity | transcription factor binding | nuclear receptor transcription coactivator activity | RNA polymerase II regulatory region sequence-specific DNA binding | transition metal ion binding | sterol response element binding | steroid binding | transcription coregulator activity | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
positive regulation of immune response | RNA metabolic process | transcription by RNA polymerase II | negative regulation of leukocyte activation | DNA-templated transcription, initiation | positive regulation of macromolecule biosynthetic process | negative regulation of immune system process | response to lipopolysaccharide | negative regulation of peptide secretion | regulation of cholesterol transport | regulation of localization | establishment of localization | regulation of immune system process | response to hormone | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cell differentiation | response to drug | negative regulation of protein secretion | regulation of response to interferon-gamma | regulation of lipid transport | hormone-mediated signaling pathway | regulation of toll-like receptor 4 signaling pathway | positive regulation of cellular biosynthetic process | cellular process | negative regulation of inflammatory response | nuclear receptor activity | localization | negative regulation of signaling | negative regulation of pancreatic juice secretion | positive regulation of cholesterol efflux | response to progesterone | regulation of digestive system process | transcription factor activity, direct ligand regulated sequence-specific DNA binding | negative regulation of nucleic acid-templated transcription | negative regulation of innate immune response | regulation of response to cytokine stimulus | negative regulation of secretion | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cholesterol storage | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | positive regulation of triglyceride biosynthetic process | regulation of cell differentiation | regulation of immune response | regulation of cellular process | cellular response to lipid | regulation of metabolic process | cellular response to molecule of bacterial origin | regulation of interferon-gamma-mediated signaling pathway | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | regulation of lipoprotein lipase activity | regulation of peptide secretion | response to stimulus | negative regulation of protein transport | negative regulation of secretion of lysosomal enzymes | positive regulation of innate immune response | regulation of macrophage derived foam cell differentiation | regulation of fatty acid biosynthetic process | positive regulation of immune system process | positive regulation of protein metabolic process | cellular nitrogen compound biosynthetic process | positive regulation of lipid biosynthetic process | sterol homeostasis | cholesterol homeostasis | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | positive regulation of lipase activity | negative regulation of transport | cellular response to organic cyclic compound | apoptotic cell clearance | regulation of protein transport | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | steroid hormone receptor activity | positive regulation of toll-like receptor 4 signaling pathway | steroid hormone mediated signaling pathway | regulation of peptide transport | cellular biosynthetic process | regulation of triglyceride metabolic process | regulation of lipid storage | positive regulation of lipoprotein lipase activity | regulation of nucleic acid-templated transcription | negative regulation of macrophage activation | cellular response to hormone stimulus | response to external biotic stimulus | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of secretion by cell | multicellular organism development | regulation of toll-like receptor signaling pathway | negative regulation of cold-induced thermogenesis | regulation of catalytic activity | lipid metabolic process | regulation of gene expression | response to ketone | response to lipid | positive regulation of cellular metabolic process | negative regulation of lipid storage | regulation of nitrogen compound metabolic process | vesicle-mediated transport | regulation of transcription by RNA polymerase II | positive regulation of hydrolase activity | regulation of fatty acid metabolic process | positive regulation of cholesterol transport | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | negative regulation of immune response | triglyceride homeostasis | positive regulation of fatty acid biosynthetic process | positive regulation of lipid localization | positive regulation of triglyceride lipase activity | regulation of macrophage activation | response to bacterium | cell communication | regulation of cellular metabolic process | negative regulation of cell activation | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | regulation of cytokine-mediated signaling pathway | transcription coactivator activity | regulation of RNA metabolic process | positive regulation of transport | regulation of lipid biosynthetic process | positive regulation of molecular function | negative regulation of interferon-gamma-mediated signaling pathway | negative regulation of lipid transport | positive regulation of triglyceride metabolic process | DNA-binding transcription factor activity | regulation of establishment of protein localization | response to organic substance | regulation of innate immune response | import into cell | positive regulation of fatty acid metabolic process | anatomical structure development | negative regulation of response to cytokine stimulus | negative regulation of endocytosis | metabolic process | regulation of receptor biosynthetic process | regulation of RNA biosynthetic process | regulation of body fluid levels | negative regulation of transcription, DNA-templated | nuclear receptor transcription coactivator activity | regulation of vesicle-mediated transport | chemical homeostasis | endocytosis | regulation of secretion | nucleobase-containing compound metabolic process | negative regulation of pinocytosis | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | regulation of cell activation | regulation of protein secretion | cellular response to steroid hormone stimulus | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | intracellular receptor signaling pathway | negative regulation of macrophage derived foam cell differentiation | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | regulation of endocytosis | regulation of nuclear receptor transcription coactivator activity | cellular macromolecule biosynthetic process | response to biotic stimulus | regulation of circadian rhythm | regulation of cellular ketone metabolic process | regulation of developmental process | regulation of cholesterol efflux | developmental process | acylglycerol homeostasis | negative regulation of transcription by RNA polymerase II | regulation of transport | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | negative regulation of cytokine-mediated signaling pathway | heterocycle metabolic process | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | positive regulation of lipid transport | cellular metabolic process | positive regulation of receptor biosynthetic process | cellular response to organic substance | regulation of protein localization | response to steroid hormone | regulation of inflammatory response | phagocytosis | regulation of triglyceride biosynthetic process | lipid homeostasis | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of toll-like receptor signaling pathway | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
nuclear transcription factor complex | chromosome | intracellular membrane-bounded organelle | RNA polymerase II transcription factor complex | cell | nuclear lumen | transcription factor complex | intracellular organelle | receptor complex | protein-containing complex | nucleoplasm | chromatin | nuclear chromosome | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | intracellular
