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QuickView for EcR;jsessionid=BB78354AC07BC482EDBF0E364213B78F;jsessionid=CD9483C312A3800C1F5712907A61048A (gene)


Gene Symbol:
Nr1h3 Rattus norvegicus Rattus norvegicus
Full name:
nuclear receptor subfamily 1, group H, member 3
Synonyms:
LXRalpha, oxysterols receptor LXR-alpha, RLD-1, liver X receptor alpha, nuclear orphan receptor LXR-alpha
Genomic Location:
Chr 3: 75542180-75550800
Description:
orphan receptor; involved in the stimulation of CYP7A1 transcription
Orthologs:
Homo sapiens Mus musculus D. melanogaster Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):





GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | retinoic acid receptor binding | nuclear receptor activity | cation binding | hormone receptor binding | transcription factor activity, direct ligand regulated sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | signaling receptor binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | steroid hormone receptor activity | RNA polymerase II regulatory region DNA binding | DNA binding | signaling receptor activity | sequence-specific double-stranded DNA binding | nuclear hormone receptor binding | protein heterodimerization activity | ion binding | organic cyclic compound binding | retinoid X receptor binding | transcription coactivator activity | transcription regulatory region sequence-specific DNA binding | protein binding | zinc ion binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | protein dimerization activity | nuclear receptor transcription coactivator activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transition metal ion binding | sterol response element binding | transcription coregulator activity | metal ion binding | heterocyclic compound binding

GO Biological Process

positive regulation of immune response | RNA metabolic process | transcription by RNA polymerase II | negative regulation of leukocyte activation | positive regulation of macromolecule biosynthetic process | negative regulation of immune system process | response to lipopolysaccharide | negative regulation of peptide secretion | regulation of cholesterol transport | regulation of localization | establishment of localization | regulation of immune system process | response to hormone | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cell differentiation | response to drug | negative regulation of protein secretion | regulation of lipid transport | hormone-mediated signaling pathway | negative regulation of proteolysis | regulation of toll-like receptor 4 signaling pathway | positive regulation of cellular biosynthetic process | cellular process | negative regulation of inflammatory response | nuclear receptor activity | localization | negative regulation of pancreatic juice secretion | positive regulation of cholesterol efflux | response to progesterone | regulation of digestive system process | transcription factor activity, direct ligand regulated sequence-specific DNA binding | negative regulation of nucleic acid-templated transcription | negative regulation of secretion | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cholesterol storage | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | response to peptide hormone | positive regulation of triglyceride biosynthetic process | regulation of immune response | regulation of cellular process | cellular response to lipid | regulation of metabolic process | cellular response to molecule of bacterial origin | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | regulation of lipoprotein lipase activity | cellular lipid metabolic process | regulation of peptide secretion | response to stimulus | negative regulation of protein transport | negative regulation of secretion of lysosomal enzymes | positive regulation of innate immune response | regulation of fatty acid biosynthetic process | positive regulation of immune system process | positive regulation of protein metabolic process | cellular nitrogen compound biosynthetic process | positive regulation of lipid biosynthetic process | sterol homeostasis | response to peptide | cholesterol homeostasis | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | positive regulation of lipase activity | negative regulation of transport | cellular response to organic cyclic compound | apoptotic cell clearance | regulation of protein transport | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | steroid hormone receptor activity | positive regulation of toll-like receptor 4 signaling pathway | steroid hormone mediated signaling pathway | regulation of peptide transport | cellular biosynthetic process | regulation of triglyceride metabolic process | regulation of lipid storage | positive regulation of lipoprotein lipase activity | regulation of nucleic acid-templated transcription | negative regulation of macrophage activation | response to nitrogen compound | cellular response to hormone stimulus | response to external biotic stimulus | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of secretion by cell | multicellular organism development | regulation of toll-like receptor signaling pathway | cellular response to peptide hormone stimulus | cellular response to insulin stimulus | regulation of catalytic activity | lipid metabolic process | regulation of gene expression | response to ketone | response to lipid | cellular response to peptide | insulin receptor signaling pathway | positive regulation of cellular metabolic process | negative regulation of lipid storage | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | vesicle-mediated transport | regulation of transcription by RNA polymerase II | positive regulation of hydrolase activity | regulation of fatty acid metabolic process | positive regulation of cholesterol transport | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | triglyceride homeostasis | positive regulation of fatty acid biosynthetic process | positive regulation of lipid localization | positive regulation of triglyceride lipase activity | regulation of macrophage activation | response to bacterium | cell communication | regulation of cellular metabolic process | negative regulation of cell activation | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | transcription coactivator activity | regulation of RNA metabolic process | positive regulation of transport | regulation of lipid biosynthetic process | positive regulation of molecular function | negative regulation of lipid transport | positive regulation of triglyceride metabolic process | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | regulation of establishment of protein localization | response to organic substance | regulation of innate immune response | import into cell | positive regulation of fatty acid metabolic process | response to insulin | anatomical structure development | cell surface receptor signaling pathway | negative regulation of endocytosis | metabolic process | regulation of receptor biosynthetic process | regulation of RNA biosynthetic process | regulation of body fluid levels | negative regulation of transcription, DNA-templated | nuclear receptor transcription coactivator activity | regulation of vesicle-mediated transport | chemical homeostasis | endocytosis | regulation of secretion | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | negative regulation of pinocytosis | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | negative regulation of cellular protein metabolic process | gene expression | regulation of cell activation | regulation of protein secretion | cellular response to steroid hormone stimulus | transcription, DNA-templated | intracellular receptor signaling pathway | negative regulation of protein metabolic process | regulation of cell communication | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | regulation of endocytosis | regulation of nuclear receptor transcription coactivator activity | cellular macromolecule biosynthetic process | response to biotic stimulus | regulation of cellular ketone metabolic process | regulation of cholesterol efflux | developmental process | acylglycerol homeostasis | negative regulation of transcription by RNA polymerase II | regulation of transport | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | positive regulation of lipid transport | cellular metabolic process | positive regulation of receptor biosynthetic process | cellular response to organic substance | regulation of protein localization | response to steroid hormone | regulation of inflammatory response | phagocytosis | regulation of triglyceride biosynthetic process | lipid homeostasis | regulation of cellular component organization | positive regulation of toll-like receptor signaling pathway | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

nuclear transcription factor complex | chromosome | intracellular membrane-bounded organelle | RNA polymerase II transcription factor complex | cell | nuclear lumen | transcription factor complex | cytoplasm | intracellular organelle | receptor complex | protein-containing complex | chromatin | nuclear chromosome | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | intracellular