QuickView for F2;jsessionid=4828180D5264C3C2F9249F29D3311CA4;jsessionid=327C8C745D70471398CDFE0F40DE2437 (gene)
- Gene Symbol:
- F2
Mus musculus - Full name:
- coagulation factor II
- Synonyms:
- Cf-2, Cf2, FII, prothrombin, thrombin
- Genomic Location:
- Chr 2: 91465477-91476571
- Description:
-
This gene encodes a vitamin K-dependent glycoprotein coagulation factor that plays an important role in the process of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that undergoes enzymatic cleavage by the coagulation factor Xa to form an active serine protease that converts soluble fibrinogen to insoluble fibrin clot...
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Bos taurus , Danio rerio , Gallus gallus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
enzyme activator activity | cation binding | thrombospondin receptor activity | lipid binding | signaling receptor binding | hydrolase activity | carbohydrate derivative binding | molecular function regulator | catalytic activity | serine hydrolase activity | anion binding | signaling receptor activity | ion binding | heparin binding | protein binding | lipopolysaccharide binding | glycosaminoglycan binding | serine-type endopeptidase activity | serine-type peptidase activity | calcium ion binding | endopeptidase activity | enzyme regulator activity | metal ion binding | peptidase activity
GO Biological Process
positive regulation of release of sequestered calcium ion into cytosol | negative regulation of cytokine production involved in inflammatory response | regulation of cell morphogenesis | regulation of neurogenesis | regulation of cellular localization | enzyme activator activity | neutrophil mediated killing of bacterium | proteolysis | regulation of cell development | regulation of localization | positive regulation of collagen metabolic process | defense response to other organism | regulation of cell shape | negative regulation of cellular process | negative regulation of astrocyte differentiation | cell differentiation | defense response | nervous system development | cellular chemical homeostasis | killing by host of symbiont cells | neurogenesis | positive regulation of phosphate metabolic process | generation of neurons | defense response to Gram-negative bacterium | negative regulation of proteolysis | interaction with symbiont | cellular process | negative regulation of gliogenesis | negative regulation of inflammatory response | cellular homeostasis | positive regulation of blood coagulation | positive regulation of reactive oxygen species metabolic process | hemostasis | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of cell differentiation | interspecies interaction between organisms | cytolysis by host of symbiont cells | negative regulation of wound healing | regulation of cellular process | positive regulation of cell growth | positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway | regulation of metabolic process | regulation of cytosolic calcium ion concentration | positive regulation of cellular protein metabolic process | calcium ion homeostasis | response to stimulus | regulation of cellular protein localization | positive regulation of protein metabolic process | positive regulation of phosphatidylinositol 3-kinase signaling | response to stress | positive regulation of cation transmembrane transport | positive regulation of cellular protein localization | regulation of cell proliferation | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | regulation of wound healing | molecular function regulator | metal ion homeostasis | blood coagulation | regulation of calcium ion transport into cytosol | response to external biotic stimulus | system development | positive regulation of response to wounding | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of calcium ion transmembrane transport | multicellular organism development | regulation of collagen biosynthetic process | leukocyte mediated immunity | regulation of catalytic activity | regulation of phosphorylation | wound healing | blood coagulation, fibrin clot formation | regulation of gene expression | cell killing | platelet activation | modification of morphology or physiology of other organism | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | positive regulation of ion transmembrane transport | regulation of protein localization to nucleus | regulation of blood coagulation | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | acute-phase response | regulation of release of sequestered calcium ion into cytosol | regulation of cytokine production involved in inflammatory response | cytolysis in other organism | positive regulation of protein localization to nucleus | regulation of cellular protein metabolic process | regulation of calcium ion transmembrane transport | protein activation cascade | cation homeostasis | fibrinolysis | negative regulation of response to wounding | response to bacterium | regulation of lipid kinase activity | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | antimicrobial humoral immune response mediated by antimicrobial peptide | humoral immune response | inflammatory response | regulation of collagen metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | cellular calcium ion homeostasis | defense response to bacterium | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | positive regulation of transport | coagulation | positive regulation of molecular function | disruption by host of symbiont cells | antimicrobial humoral response | protein metabolic process | positive regulation of protein modification process | regulation of growth | regulation of kinase activity | response to wounding | killing of cells of other organism | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | metabolic process | regulation of body fluid levels | positive regulation of coagulation | chemical homeostasis | immune response | leukocyte mediated cytotoxicity | organic substance metabolic process | regulation of sequestering of calcium ion | positive regulation of ion transport | negative regulation of cellular protein metabolic process | positive regulation of G-protein coupled receptor protein signaling pathway | positive regulation of kinase activity | thrombin-activated receptor signaling pathway | ion homeostasis | serine-type endopeptidase activity | regulation of phosphate metabolic process | positive regulation of wound healing | regulation of ion transmembrane transport | serine-type peptidase activity | cell activation | negative regulation of protein metabolic process | regulation of glial cell differentiation | regulation of response to wounding | regulation of cell communication | regulation of gliogenesis | signaling | positive regulation of growth | endopeptidase activity | positive regulation of phosphorylation | enzyme regulator activity | regulation of cytokine production | positive regulation of calcium ion transport into cytosol | response to biotic stimulus | regulation of nervous system development | regulation of developmental process | regulation of ion transport | regulation of G-protein coupled receptor protein signaling pathway | developmental process | regulation of cell growth | neutrophil mediated killing of gram-negative bacterium | regulation of calcium ion transport | negative regulation of glial cell differentiation | negative regulation of coagulation | regulation of transport | regulation of reactive oxygen species metabolic process | positive regulation of lipid kinase activity | neutrophil mediated immunity | cytolysis | cellular metal ion homeostasis | cytolysis in other organism involved in symbiotic interaction | negative regulation of blood coagulation | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | acute inflammatory response | immune system process | positive regulation of collagen biosynthetic process | peptidase activity | regulation of protein localization | regulation of astrocyte differentiation | negative regulation of cell development | regulation of inflammatory response | divalent inorganic cation homeostasis | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of calcium ion transport | response to other organism | positive regulation of signaling | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
extracellular matrix | cell | external side of plasma membrane | plasma membrane | extracellular region | extracellular space | cell periphery | cell surface | membrane
