QuickView for F2;jsessionid=4828180D5264C3C2F9249F29D3311CA4;jsessionid=43BEA50414F1E64B1121BA4DE411EFC7 (gene)
- Gene Symbol:
- F2
Rattus norvegicus - Full name:
- coagulation factor II
- Synonyms:
- prothrombin, coagulation factor 2, thrombin
- Genomic Location:
- Chr 3: 76005323-76018608
- Description:
-
catalyzes the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptides A and B; involved in blood coagulation and wound repair
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Bos taurus , Danio rerio , Gallus gallus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
enzyme activator activity | cation binding | thrombospondin receptor activity | lipid binding | signaling receptor binding | hydrolase activity | carbohydrate derivative binding | molecular function regulator | catalytic activity | serine hydrolase activity | anion binding | signaling receptor activity | ion binding | heparin binding | protein binding | lipopolysaccharide binding | glycosaminoglycan binding | serine-type endopeptidase activity | serine-type peptidase activity | calcium ion binding | endopeptidase activity | enzyme regulator activity | metal ion binding | peptidase activity
GO Biological Process
positive regulation of release of sequestered calcium ion into cytosol | negative regulation of cytokine production involved in inflammatory response | regulation of cell morphogenesis | regulation of neurogenesis | regulation of cellular localization | enzyme activator activity | neutrophil mediated killing of bacterium | proteolysis | regulation of cell development | regulation of localization | positive regulation of collagen metabolic process | defense response to other organism | response to hormone | regulation of cell shape | negative regulation of cellular process | negative regulation of astrocyte differentiation | cell differentiation | defense response | nervous system development | response to drug | cellular chemical homeostasis | killing by host of symbiont cells | neurogenesis | positive regulation of phosphate metabolic process | generation of neurons | defense response to Gram-negative bacterium | negative regulation of proteolysis | interaction with symbiont | cellular process | negative regulation of gliogenesis | negative regulation of inflammatory response | cellular homeostasis | positive regulation of blood coagulation | positive regulation of reactive oxygen species metabolic process | hemostasis | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | response to peptide hormone | regulation of cell differentiation | interspecies interaction between organisms | cytolysis by host of symbiont cells | negative regulation of wound healing | regulation of cellular process | positive regulation of cell growth | positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway | regulation of metabolic process | regulation of cytosolic calcium ion concentration | positive regulation of cellular protein metabolic process | calcium ion homeostasis | response to Thyroglobulin triiodothyronine | response to stimulus | regulation of cellular protein localization | cellular response to mechanical stimulus | positive regulation of protein metabolic process | positive regulation of phosphatidylinositol 3-kinase signaling | response to stress | positive regulation of cation transmembrane transport | positive regulation of cellular protein localization | regulation of cell proliferation | response to peptide | negative regulation of metabolic process | regulation of wound healing | molecular function regulator | metal ion homeostasis | blood coagulation | response to nitrogen compound | regulation of calcium ion transport into cytosol | response to inactivity | response to external biotic stimulus | system development | positive regulation of response to wounding | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of calcium ion transmembrane transport | multicellular organism development | response to amino acid | regulation of collagen biosynthetic process | leukocyte mediated immunity | regulation of catalytic activity | regulation of phosphorylation | wound healing | blood coagulation, fibrin clot formation | regulation of gene expression | cell killing | platelet activation | modification of morphology or physiology of other organism | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | response to thyrotropin-releasing hormone | positive regulation of ion transmembrane transport | regulation of protein localization to nucleus | regulation of blood coagulation | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | acute-phase response | regulation of release of sequestered calcium ion into cytosol | regulation of cytokine production involved in inflammatory response | cytolysis in other organism | positive regulation of protein localization to nucleus | regulation of cellular protein metabolic process | regulation of calcium ion transmembrane transport | protein activation cascade | cation homeostasis | fibrinolysis | negative regulation of response to wounding | response to bacterium | regulation of lipid kinase activity | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | antimicrobial humoral immune response mediated by antimicrobial peptide | humoral immune response | inflammatory response | regulation of collagen metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | cellular calcium ion homeostasis | defense response to bacterium | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | positive regulation of transport | coagulation | positive regulation of molecular function | disruption by host of symbiont cells | antimicrobial humoral response | protein metabolic process | positive regulation of protein modification process | regulation of growth | response to organic substance | response to L-phenylalanine derivative | regulation of kinase activity | response to wounding | response to mechanical stimulus | killing of cells of other organism | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | metabolic process | regulation of body fluid levels | positive regulation of coagulation | chemical homeostasis | immune response | leukocyte mediated cytotoxicity | organic substance metabolic process | regulation of sequestering of calcium ion | positive regulation of ion transport | negative regulation of cellular protein metabolic process | positive regulation of G-protein coupled receptor protein signaling pathway | positive regulation of kinase activity | ion homeostasis | serine-type endopeptidase activity | regulation of phosphate metabolic process | positive regulation of wound healing | regulation of ion transmembrane transport | serine-type peptidase activity | cell activation | negative regulation of protein metabolic process | regulation of glial cell differentiation | regulation of response to wounding | regulation of cell communication | regulation of gliogenesis | signaling | positive regulation of growth | response to organic cyclic compound | endopeptidase activity | positive regulation of phosphorylation | enzyme regulator activity | regulation of cytokine production | positive regulation of calcium ion transport into cytosol | response to biotic stimulus | regulation of nervous system development | regulation of developmental process | regulation of ion transport | regulation of G-protein coupled receptor protein signaling pathway | developmental process | regulation of cell growth | neutrophil mediated killing of gram-negative bacterium | regulation of calcium ion transport | response to thyroid hormone | negative regulation of glial cell differentiation | negative regulation of coagulation | regulation of transport | regulation of reactive oxygen species metabolic process | positive regulation of lipid kinase activity | neutrophil mediated immunity | response to organonitrogen compound | cytolysis | cellular metal ion homeostasis | cytolysis in other organism involved in symbiotic interaction | response to thyroxine | negative regulation of blood coagulation | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | acute inflammatory response | immune system process | positive regulation of collagen biosynthetic process | peptidase activity | regulation of protein localization | regulation of astrocyte differentiation | negative regulation of cell development | regulation of inflammatory response | divalent inorganic cation homeostasis | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of calcium ion transport | response to other organism | positive regulation of signaling | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
extracellular matrix | cell | external side of plasma membrane | plasma membrane | extracellular region | extracellular space | cell periphery | cell surface | membrane
