QuickView for FGA;jsessionid=99A47BBCFF75D02249FAB1AEC3EA0BD9;jsessionid=D7FDC39759F23EAEF26397747FAEFC58 (gene)

Gene Symbol:

Fga Mus musculus

Full name:

fibrinogen alpha chain

Synonyms:

Fib, fibrinogen alpha chain, fibrinogen, A alpha polypeptide

Genomic Location:

Chr 3: 82830076-82836192

Description:

This gene encodes a subunit of the coagulation factor fibrinogen, which is a component of the blood clot. The encoded protein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mice lacking the encoded protein display bleeding in the peritoneal cavity, skin and soft tissues around joints immediately after birth,...

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This gene encodes a subunit of the coagulation factor fibrinogen, which is a component of the blood clot. The encoded protein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mice lacking the encoded protein display bleeding in the peritoneal cavity, skin and soft tissues around joints immediately after birth, and are predisposed to spontaneous fatal abdominal hemorrhage as they grow. Pregnant mice lacking the encoded protein succumb to uterine bleeding during gestation. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CEBPB_02 ,  HNF1_01 ,  HNF1_C ,  STAT_01 ,  STAT5A_01 ,  STAT5B_01 ,  HNF1_Q6 ,  CEBP_Q2_01 ,  AR_Q6 ,  GTACTGT_MIR101 ,  TTANTCA_UNKNOWN ,  TTGCWCAAY_CEBPB_02 ,  TTGTTT_FOXO4_01 ,  TGTTTGY_HNF3_Q6 ,  TTCYNRGAA_STAT5B_01 ,  WGGAATGY_TEF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-29

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