QuickView for FGB;jsessionid=825D675C81B4C76125734F0E042C7FB1;jsessionid=080F5194B3027A4B916051B659B19080 (gene)
- Gene Symbol:
- Fgb
Mus musculus - Full name:
- fibrinogen beta chain
- Synonyms:
- 2510049G14Rik, fibrinogen beta chain, fibrinogen, B beta polypeptide
- Genomic Location:
- Chr 3: 82846225-82853712
- Description:
-
This gene encodes the beta subunit of the coagulation factor fibrinogen, which is a component of the blood clot. The encoded preproprotein is proteolytically processed by thrombin to release an N-terminal fibrinopeptide during the conversion of fibrinogen to insoluble fibrin polymer. The encoded protein interacts with the amyloid beta peptide to fo...
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
structural molecule activity | signaling receptor binding | chaperone binding | cell adhesion molecule binding | protein binding
GO Biological Process
regulation of ERK1 and ERK2 cascade | adaptive immune response | regulation of blood vessel diameter | positive regulation of blood circulation | proteolysis | regulation of localization | cell-substrate adhesion | regulation of programmed cell death | defense response to other organism | negative regulation of cellular process | protein processing | response to metal ion | defense response | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | regulation of peptide hormone secretion | positive regulation of protein secretion | cellular process | zymogen activation | negative regulation of signaling | positive regulation of heterotypic cell-cell adhesion | hemostasis | negative regulation of apoptotic process | positive regulation of nitrogen compound metabolic process | induction of bacterial agglutination | response to inorganic substance | positive regulation of vasoconstriction | negative regulation of apoptotic signaling pathway | negative regulation of wound healing | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | cellular component organization | platelet aggregation | regulation of peptide secretion | response to stimulus | negative regulation of epithelial cell apoptotic process | positive regulation of protein metabolic process | regulation of blood vessel size | response to stress | regulation of heterotypic cell-cell adhesion | regulation of blood circulation | positive regulation of cell-cell adhesion | positive regulation of hormone secretion | regulation of protein transport | blood circulation | cellular component assembly | regulation of wound healing | regulation of peptide transport | regulation of cell adhesion | blood coagulation | positive regulation of peptide secretion | positive regulation of exocytosis | response to external biotic stimulus | nitrogen compound metabolic process | regulation of signal transduction | antibacterial humoral response | regulation of MAPK cascade | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | wound healing | blood coagulation, fibrin clot formation | regulation of extrinsic apoptotic signaling pathway | platelet activation | positive regulation of secretion | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of blood coagulation | regulation of nitrogen compound metabolic process | protein polymerization | positive regulation of intracellular signal transduction | regulation of endothelial cell apoptotic process | negative regulation of extrinsic apoptotic signaling pathway | regulation of cellular protein metabolic process | cellular protein-containing complex assembly | protein maturation | protein activation cascade | regulation of apoptotic signaling pathway | regulation of epithelial cell apoptotic process | fibrinolysis | negative regulation of response to wounding | response to bacterium | regulation of cellular metabolic process | humoral immune response | regulation of protein metabolic process | positive regulation of signal transduction | defense response to bacterium | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of tube size | positive regulation of transport | positive regulation of peptide hormone secretion | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | coagulation | antimicrobial humoral response | protein-containing complex assembly | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | response to wounding | regulation of intracellular signal transduction | regulation of exocytosis | regulation of vasoconstriction | metabolic process | regulation of body fluid levels | negative regulation of programmed cell death | regulation of tube diameter | regulation of vesicle-mediated transport | regulation of secretion | cell adhesion | immune response | organic substance metabolic process | gene expression | regulation of protein secretion | positive regulation of ERK1 and ERK2 cascade | regulation of phosphate metabolic process | cell-cell adhesion | cell activation | positive regulation of MAPK cascade | positive regulation of protein transport | regulation of response to wounding | regulation of cell communication | negative regulation of signal transduction | regulation of extrinsic apoptotic signaling pathway via death domain receptors | cell-matrix adhesion | positive regulation of phosphorylation | response to biotic stimulus | negative regulation of coagulation | regulation of transport | regulation of cell-cell adhesion | innate immune response | response to calcium ion | negative regulation of blood coagulation | plasminogen activation | positive regulation of metabolic process | immune system process | regulation of protein localization | regulation of cell death | negative regulation of cell death | homotypic cell-cell adhesion | response to other organism | positive regulation of signaling | regulation of signaling | negative regulation of endothelial cell apoptotic process | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
secretory granule | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | external side of plasma membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | platelet alpha granule | fibrinogen complex | protein-containing complex | secretory vesicle | endomembrane system | plasma membrane | vesicle | cytoplasmic region | extracellular region | cell cortex | membrane-bounded organelle | organelle | extracellular space | cell periphery | blood microparticle | intracellular vesicle | cell surface | intracellular | membrane
