QuickView for Flt1;jsessionid=AE965446A2DABC210FCB1317C4ED3090;jsessionid=3266CE5D7A13A80B695FF2B57AC99A11 (gene)
- Gene Symbol:
- Flt1
Rattus norvegicus - Full name:
- FMS-related tyrosine kinase 1
- Synonyms:
- FLT-1, VEGFR-1, vascular endothelial growth factor receptor 1, FMS-like tyrosine kinase 1, Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), tyrosine-protein kinase receptor FLT, vascular endothelial growth factor receptor 1-like, vascular endothelial growth factor/vascular permeability factor receptor
- Genomic Location:
- Chr 12: 7858092-8035966
- Description:
-
tyrosine kinase receptor for vascular endothelial growth factor; may play a role in cell proliferation and cell survival
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Gallus gallus , Canis lupus familiaris , Pan troglodytes , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
VEGF-B-activated receptor activity | transmembrane receptor protein tyrosine kinase activity | transmembrane signaling receptor activity | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | growth factor binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | vascular endothelial growth factor-activated receptor activity | signaling receptor activity | purine nucleotide binding | identical protein binding | VEGF-A-activated receptor activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein tyrosine kinase activity | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | placental growth factor-activated receptor activity | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
positive regulation of smooth muscle cell proliferation | regulation of ERK1 and ERK2 cascade | regulation of muscle system process | vascular endothelial growth factor receptor-1 signaling pathway | cellular response to decreased oxygen levels | positive regulation of locomotion | cell motility | regulation of neurogenesis | regulation of cell development | VEGF-B-activated receptor activity | regulation of localization | morphogenesis of an epithelium | regulation of programmed cell death | peptidyl-amino acid modification | transmembrane receptor protein tyrosine kinase activity | eye development | positive regulation of hematopoietic progenitor cell differentiation | regulation of immune system process | response to hormone | negative regulation of vascular endothelial cell proliferation | negative regulation of cellular process | positive regulation of developmental process | regulation of MAP kinase activity | cell differentiation | positive regulation of fibroblast proliferation | nervous system development | regulation of smooth muscle contraction | response to drug | regulation of hematopoietic progenitor cell differentiation | regulation of sprouting angiogenesis | neurogenesis | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | post-embryonic animal organ morphogenesis | positive regulation of cellular component movement | generation of neurons | response to antibiotic | positive regulation of vascular endothelial growth factor receptor signaling pathway | blood vessel morphogenesis | positive regulation of phosphatidylinositol 3-kinase activity | cellular process | regulation of cell motility | localization | epithelial tube morphogenesis | negative regulation of signaling | response to estradiol | regulation of vascular endothelial growth factor receptor signaling pathway | female pregnancy | positive regulation of protein kinase activity | negative regulation of apoptotic process | response to hypoxia | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | tissue development | regulation of cell differentiation | regeneration | regulation of angiogenesis | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | hepaticobiliary system development | positive regulation of cellular protein metabolic process | epithelium development | sprouting angiogenesis | branching involved in blood vessel morphogenesis | regulation of vasculature development | response to stimulus | vasculature development | cellular response to vascular endothelial growth factor stimulus | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of phosphatidylinositol 3-kinase signaling | cellular response to hypoxia | response to stress | post-embryonic camera-type eye development | regulation of cell proliferation | negative regulation of angiogenesis | tube morphogenesis | reproduction | response to alcohol | cardiovascular system development | positive regulation of lipase activity | positive regulation of gliogenesis | positive regulation of protein serine/threonine kinase activity | monocyte chemotaxis | protein modification process | embryo development | regulation of phosphatidylinositol 3-kinase activity | macromolecule modification | cell chemotaxis | activation of protein kinase activity | blood vessel development | response to ethanol | leukocyte migration | locomotion | positive regulation of phospholipase C activity | system development | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | post-embryonic animal organ development | multicellular organism development | response to activity | cell migration | regulation of MAPK cascade | phosphorus metabolic process | regulation of muscle contraction | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | post-embryonic camera-type eye morphogenesis | vascular endothelial growth factor-activated receptor activity | cellular response to stress | response to lipid | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | animal organ morphogenesis | liver development | cellular response to oxygen levels | vascular endothelial growth factor signaling pathway | protein autophosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | post-embryonic animal morphogenesis | positive regulation of intracellular signal transduction | regulation of cellular component movement | positive regulation of hydrolase activity | positive regulation of cell differentiation | positive regulation of cell migration | VEGF-A-activated receptor activity | regulation of cellular protein metabolic process | angiogenesis | phosphorylation | regulation of phospholipase activity | response to toxic substance | protein phosphorylation | post-embryonic development | phosphate-containing compound metabolic process | sensory organ development | regulation of lipid kinase activity | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | liver regeneration | eye morphogenesis | regulation of glial cell proliferation | activation of MAPKK activity | regulation of protein metabolic process | positive regulation of signal transduction | leukocyte chemotaxis | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | post-embryonic eye morphogenesis | regulation of phospholipid metabolic process | negative regulation of sprouting angiogenesis | regulation of cellular response to growth factor stimulus | embryonic morphogenesis | protein tyrosine kinase activity | regulation of phospholipase C activity | positive regulation of glial cell proliferation | positive regulation of molecular function | negative regulation of epithelial cell proliferation | protein metabolic process | regulation of fibroblast proliferation | positive regulation of protein modification process | response to organic substance | gland development | tissue morphogenesis | regulation of hemopoiesis | branching morphogenesis of an epithelial tube | regulation of kinase activity | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | positive regulation of neurogenesis | metabolic process | positive regulation of cell development | negative regulation of programmed cell death | negative regulation of endothelial cell proliferation | protein kinase activity | organic substance metabolic process | animal organ development | regulation of endothelial cell proliferation | positive regulation of ERK1 and ERK2 cascade | positive regulation of kinase activity | regulation of phosphate metabolic process | positive regulation of phospholipase activity | positive regulation of MAPK cascade | intracellular receptor signaling pathway | morphogenesis of a branching epithelium | camera-type eye development | anatomical structure formation involved in morphogenesis | regulation of cell communication | regulation of gliogenesis | negative regulation of signal transduction | signaling | response to organic cyclic compound | regulation of epithelial cell proliferation | positive regulation of phosphorylation | placental growth factor-activated receptor activity | cellular protein metabolic process | regulation of cytokine production | morphogenesis of a branching structure | anatomical structure morphogenesis | camera-type eye morphogenesis | positive regulation of MAP kinase activity | regulation of nervous system development | regulation of developmental process | kinase activity | developmental process | cellular protein modification process | vascular endothelial growth factor receptor signaling pathway | tube development | negative regulation of cell proliferation | negative regulation of vasculature development | positive regulation of lipid kinase activity | regulation of vascular endothelial growth factor production | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | immune system process | cellular metabolic process | cellular response to organic substance | regulation of cell death | regulation of smooth muscle cell proliferation | positive regulation of cell motility | negative regulation of cell death | circulatory system development | aging | negative regulation of vascular endothelial growth factor production | chemotaxis | positive regulation of angiogenesis | positive regulation of signaling | signal transduction | mononuclear cell migration | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | animal organ regeneration | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | actin cytoskeleton | receptor complex | protein-containing complex | endomembrane system | plasma membrane | vesicle | integral component of plasma membrane | endosome | extracellular region | membrane-bounded organelle | nucleus | organelle | extracellular space | cell periphery | intracellular vesicle | cytoskeleton | intracellular | membrane | intrinsic component of plasma membrane
