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QuickView for Foxp3;jsessionid=BB2BADE7839F01EDF82804449A5D4DEB;jsessionid=274C708D8702AEC63F51B26DB52698AA (gene)


Gene Symbol:
Foxp3 Rattus norvegicus Rattus norvegicus
Full name:
forkhead box P3
Synonyms:
RGD1562112, forkhead box protein P3
Genomic Location:
Chr X: 26952157-26959255
Orthologs:
Homo sapiens Mus musculus Macaca mulatta Canis lupus familiaris Bos taurus Danio rerio Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:


Protein Names
D3ZKI1
D4Q8I2



GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | NFAT protein binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | transcription corepressor activity | identical protein binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | histone acetyltransferase binding | protein homodimerization activity | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | DNA-binding transcription factor activity | transcription factor binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | histone deacetylase binding | transcription coregulator activity | heterocyclic compound binding

GO Biological Process

positive regulation of immune response | negative regulation of lymphocyte differentiation | RNA metabolic process | leukocyte homeostasis | negative regulation of leukocyte activation | regulation of T cell mediated immunity | adaptive immune response | positive regulation of macromolecule biosynthetic process | response to virus | negative regulation of immune system process | CD4-positive, alpha-beta T cell differentiation | positive regulation of cellular component organization | regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation | regulation of B cell activation | CD4-positive, alpha-beta T cell activation | immune response-regulating signaling pathway | negative regulation of peptide secretion | regulation of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | regulation of immature T cell proliferation in thymus | regulation of T-helper 17 type immune response | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of leukocyte cell-cell adhesion | positive regulation of developmental process | negative regulation of RNA biosynthetic process | positive regulation of lymphocyte activation | cell differentiation | immune response-activating cell surface receptor signaling pathway | regulation of T cell differentiation | T cell receptor signaling pathway | positive regulation of cell adhesion | negative regulation of protein secretion | regulation of organelle organization | negative regulation of chronic inflammatory response | negative regulation of DNA metabolic process | regulation of isotype switching to IgG isotypes | positive regulation of T cell differentiation | positive regulation of cellular biosynthetic process | cellular process | positive regulation of T cell differentiation in thymus | negative regulation of inflammatory response | lymphocyte differentiation | regulation of cytokine biosynthetic process | positive regulation of immune effector process | positive regulation of T cell tolerance induction | positive regulation of adaptive immune response | tolerance induction | immune system development | negative regulation of nucleic acid-templated transcription | negative regulation of alpha-beta T cell differentiation | regulation of histone modification | negative regulation of secretion | negative regulation of T-helper 17 cell differentiation | positive regulation of nitrogen compound metabolic process | negative regulation of T cell proliferation | negative regulation of peptidyl-lysine acetylation | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | regulation of cell differentiation | negative regulation of CD4-positive, alpha-beta T cell activation | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of metabolic process | negative regulation of cytokine secretion | negative regulation of CREB transcription factor activity | negative regulation of mononuclear cell proliferation | tolerance induction to self antigen | negative regulation of tumor necrosis factor production | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | positive regulation of interleukin-4 production | T cell activation | regulation of peptide secretion | response to stimulus | negative regulation of protein transport | regulation of DNA recombination | regulation of regulatory T cell differentiation | positive regulation of peripheral T cell tolerance induction | positive regulation of immune system process | positive regulation of protein metabolic process | negative regulation of cell adhesion | regulation of CD4-positive, alpha-beta T cell activation | negative regulation of tumor necrosis factor superfamily cytokine production | negative regulation of lymphocyte activation | positive regulation of lymphocyte proliferation | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | negative regulation of interferon-gamma production | positive regulation of cell-cell adhesion | positive regulation of cell activation | cellular nitrogen compound metabolic process | regulation of T cell anergy | positive regulation of T cell activation | immune response-activating signal transduction | negative regulation of transport | regulation of protein transport | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | negative regulation of hemopoiesis | regulation of peptide transport | regulation of cell adhesion | cellular biosynthetic process | regulation of lymphocyte differentiation | negative regulation of adaptive immune response | myeloid cell homeostasis | regulation of nucleic acid-templated transcription | negative regulation of NF-kappaB transcription factor activity | leukocyte differentiation | regulation of tolerance induction dependent upon immune response | regulation of interleukin-2 biosynthetic process | positive regulation of mononuclear cell proliferation | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | response to external biotic stimulus | system development | regulation of interleukin-4 production | nitrogen compound metabolic process | positive regulation of organelle organization | negative regulation of immunoglobulin production | negative regulation of secretion by cell | negative regulation of T-helper cell differentiation | negative regulation of interleukin-6 production | multicellular organism development | positive regulation of lymphocyte differentiation | leukocyte mediated immunity | regulation of CD4-positive, alpha-beta T cell differentiation | positive regulation of chromosome organization | regulation of T cell activation | positive regulation of alpha-beta T cell differentiation | regulation of gene expression | negative regulation of T-helper 17 type immune response | negative regulation of cytokine production | positive regulation of cellular metabolic process | negative regulation of interferon-gamma biosynthetic process | regulation of lymphocyte activation | regulation of tolerance induction | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | negative regulation of DNA-binding transcription factor activity | transcription corepressor activity | regulation of transcription by RNA polymerase II | alpha-beta T cell differentiation | positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation | negative regulation of interleukin-17 production | regulation of T-helper 17 cell differentiation | B cell homeostasis | positive regulation of cell differentiation | regulation of T cell cytokine production | homeostasis of number of cells | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | positive regulation of T cell proliferation | negative regulation of immune response | regulation of tumor necrosis factor production | negative regulation of cytokine biosynthetic process | negative regulation of cell-cell adhesion | cell communication | regulation of cellular metabolic process | regulation of protein deacetylation | regulation of alpha-beta T cell differentiation | lymphocyte homeostasis | negative regulation of cell activation | T cell mediated immunity | regulation of cytokine production involved in immune response | regulation of protein metabolic process | negative regulation of interleukin-2 production | homeostatic process | positive regulation of cell proliferation | negative regulation of CD4-positive, alpha-beta T cell differentiation | regulation of RNA metabolic process | positive regulation of protein acetylation | negative regulation of T cell differentiation | negative regulation of B cell activation | lymphocyte activation | regulation of cytokine secretion | cytokine production | T cell differentiation | positive regulation of transforming growth factor beta production | activation of immune response | DNA-binding transcription factor activity | regulation of establishment of protein localization | positive regulation of protein modification process | negative regulation of interleukin-2 biosynthetic process | regulation of hemopoiesis | positive regulation of immature T cell proliferation | negative regulation of histone deacetylation | regulation of DNA-binding transcription factor activity | positive regulation of peptidyl-lysine acetylation | negative regulation of isotype switching to IgE isotypes | anatomical structure development | cell surface receptor signaling pathway | regulation of chronic inflammatory response | metabolic process | regulation of isotype switching | regulation of adaptive immune response | negative regulation of leukocyte proliferation | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | regulation of T cell tolerance induction | negative regulation of transcription, DNA-templated | negative regulation of interleukin-4 production | negative regulation of histone acetylation | regulation of interleukin-5 production | regulation of secretion | immune response | nucleobase-containing compound metabolic process | organic substance metabolic process | positive regulation of transforming growth factor beta1 production | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | positive regulation of histone modification | negative regulation of cellular protein metabolic process | gene expression | regulation of cell activation | regulation of protein secretion | regulatory T cell differentiation | alpha-beta T cell activation | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | regulation of chromosome organization | antigen receptor-mediated signaling pathway | negative regulation of T cell mediated immunity | transcription, DNA-templated | positive regulation of cytokine production | cell activation | positive regulation of T cell mediated immunity | regulation of T-helper cell differentiation | negative regulation of protein metabolic process | negative regulation of DNA recombination | negative regulation of chromosome organization | negative regulation of molecular function | CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation | signaling | regulation of immunoglobulin production | regulation of transcription, DNA-templated | regulation of T cell proliferation | positive regulation of CD4-positive, alpha-beta T cell differentiation | regulation of T cell differentiation in thymus | regulation of cytokine production | positive regulation of regulatory T cell differentiation | cellular macromolecule biosynthetic process | response to biotic stimulus | regulation of developmental process | developmental process | positive regulation of alpha-beta T cell activation | negative regulation of alpha-beta T cell activation | positive regulation of T cell anergy | regulation of histone acetylation | negative regulation of transcription by RNA polymerase II | positive regulation of histone acetylation | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | regulation of cell-cell adhesion | positive regulation of tolerance induction | positive regulation of nucleic acid-templated transcription | negative regulation of protein acetylation | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | regulation of histone deacetylation | positive regulation of metabolic process | negative regulation of interleukin-5 production | regulation of interferon-gamma production | negative regulation of lymphocyte proliferation | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | regulation of protein localization | positive regulation of CD4-positive, alpha-beta T cell activation | regulation of interleukin-6 production | regulation of inflammatory response | positive regulation of leukocyte cell-cell adhesion | positive regulation of immature T cell proliferation in thymus | negative regulation of cell differentiation | regulation of cellular component organization | negative regulation of T cell cytokine production | response to other organism | signal transduction | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | negative regulation of interleukin-10 production | regulation of chromatin organization

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular