QuickView for GCLC;jsessionid=9458CF7126141EC75D74CCC3AA559853;jsessionid=17BD8C6A6242BB24A2CDEF680B96E636 (gene)
- Gene Symbol:
- Gclc
Mus musculus - Full name:
- glutamate-cysteine ligase, catalytic subunit
- Synonyms:
- D9Wsu168e, GLCL-H, Ggcs-hs, Glclc, glutamate--cysteine ligase catalytic subunit, GCS heavy chain, gamma GCS-HS, gamma-ECS, gamma-glutamylcysteine synthetase heavy subunit
- Genomic Location:
- Chr 9: 77602617-77641458
- Orthologs:
- Homo sapiens , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Bos taurus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
ADP binding | cofactor binding | glutamate-cysteine ligase activity | cation binding | magnesium ion binding | carboxylic acid binding | ribonucleotide binding | nucleotide binding | coenzyme binding | carbohydrate derivative binding | acid-amino acid ligase activity | catalytic activity | ATP binding | ligase activity, forming carbon-nitrogen bonds | anion binding | adenyl nucleotide binding | amino acid binding | purine nucleotide binding | protein heterodimerization activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | protein dimerization activity | ligase activity | glutamate binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | organic acid binding | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
sulfur compound metabolic process | regulation of programmed cell death | glutathione metabolic process | response to hormone | negative regulation of neuron death | negative regulation of cellular process | negative regulation of RNA biosynthetic process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | positive regulation of protein catabolic process | regulation of neuron death | cellular process | cellular homeostasis | dicarboxylic acid metabolic process | regulation of mitochondrial membrane potential | negative regulation of signaling | serine family amino acid metabolic process | negative regulation of nucleic acid-templated transcription | negative regulation of apoptotic process | regulation of proteolysis | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | negative regulation of apoptotic signaling pathway | cellular amino acid metabolic process | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | regulation of mitochondrial depolarization | cellular component organization | positive regulation of cellular protein catabolic process | response to stimulus | peptide biosynthetic process | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | regulation of blood vessel size | response to stress | cell redox homeostasis | cellular nitrogen compound biosynthetic process | regulation of protein ubiquitination | programmed cell death | positive regulation of proteolysis involved in cellular protein catabolic process | response to temperature stimulus | positive regulation of proteolysis | cellular nitrogen compound metabolic process | apoptotic mitochondrial changes | blood circulation | negative regulation of metabolic process | cofactor metabolic process | cellular biosynthetic process | mitochondrion organization | regulation of nucleic acid-templated transcription | regulation of membrane potential | negative regulation of neuron apoptotic process | apoptotic process | sulfur amino acid metabolic process | nitrogen compound metabolic process | regulation of signal transduction | response to nitrosative stress | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | glutamate metabolic process | regulation of membrane depolarization | positive regulation of cellular metabolic process | cofactor biosynthetic process | regulation of hepatic stellate cell activation | regulation of nitrogen compound metabolic process | monosaccharide metabolic process | small molecule metabolic process | cellular amide metabolic process | response to oxidative stress | negative regulation of extrinsic apoptotic signaling pathway | biosynthetic process | regulation of cellular protein metabolic process | positive regulation of proteasomal protein catabolic process | carbohydrate metabolic process | regulation of apoptotic signaling pathway | response to xenobiotic stimulus | regulation of cellular metabolic process | regulation of neuron apoptotic process | L-ascorbic acid metabolic process | negative regulation of cell activation | regulation of protein metabolic process | homeostatic process | peptide metabolic process | regulation of RNA metabolic process | negative regulation of protein ubiquitination | regulation of tube size | carboxylic acid metabolic process | regulation of proteasomal ubiquitin-dependent protein catabolic process | response to organic substance | glutathione biosynthetic process | vitamin metabolic process | metabolic process | positive regulation of ubiquitin-dependent protein catabolic process | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | regulation of proteasomal protein catabolic process | chemical homeostasis | organic substance metabolic process | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | negative regulation of cellular protein metabolic process | amide biosynthetic process | regulation of cell activation | response to heat | ion homeostasis | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of signal transduction | response to arsenic-containing substance | regulation of transcription, DNA-templated | organic acid metabolic process | cysteine metabolic process | organelle organization | cellular modified amino acid metabolic process | negative regulation of hepatic stellate cell activation | positive regulation of metabolic process | cellular metabolic process | regulation of cell death | negative regulation of cell death | regulation of ubiquitin-dependent protein catabolic process | regulation of signaling | multicellular organismal process
GO Cellular Component
catalytic complex | cell | cytoplasm | protein-containing complex | glutamate-cysteine ligase complex | cytosol | intracellular
