QuickView for GCN2;jsessionid=EDA9BF8F9468D4BB7E75667668C1837D;jsessionid=3E80F8E980951494E68ABE972AEC6184 (gene)

Gene Symbol:

EIF2AK4 Homo sapiens

Full name:

eukaryotic translation initiation factor 2 alpha kinase 4

Synonyms:

GCN2, PVOD2, eIF-2-alpha kinase GCN2, GCN2 eIF2alpha kinase, GCN2-like protein, general control nonderepressible 2

Genomic Location:

Chr 15: 38013639-38115089

Description:

This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infecti...

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This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Danio rerio ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Cytogenetic Map:

15q15.1

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