QuickView for GRIA2;jsessionid=FEB761F02F75E298FB641085E860D29C;jsessionid=F0683E0C0F8CCCF30E194AA44E3007D9 (gene)

Gene Symbol:

Gria2 Mus musculus

Full name:

glutamate receptor, ionotropic, AMPA2 (alpha 2)

Synonyms:

GluA2, GluR-B, Glur-2, Glur2, gluR-K2, glutamate receptor 2, AMPA selective glutamate receptor, AMPA-selective glutamate receptor 2, glutamate receptor B, glutamate receptor ionotropic, AMPA 2

Genomic Location:

Chr 3: 80488858-80606713

Description:

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated ca...

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Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  GTGCCTT_MIR506 ,  GCTTGAA_MIR498 ,  GTGGTGA_MIR197 ,  CATGTAA_MIR496 ,  AAGCACA_MIR218 ,  CTTTGTA_MIR524 ,  CTCCAAG_MIR432 ,  TGCCTTA_MIR124A ,  TACAATC_MIR508 ,  GTTATAT_MIR410 ,  TAATAAT_MIR126

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-335 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-486

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