QuickView for GluR2;jsessionid=00736F6DA22D1CF265B8EAFC13BEFDF4;jsessionid=28B2EF090DE945003941C0162AAD6555 (gene)

Gene Symbol:

GRIA2 Homo sapiens

Full name:

glutamate ionotropic receptor AMPA type subunit 2

Synonyms:

GLUR2, GLURB, GluA2, GluR-K2, HBGR2, glutamate receptor 2, AMPA-selective glutamate receptor 2, gluR-2, gluR-B, glutamate receptor B flip isoform, glutamate receptor, ionotropic, AMPA 2

Genomic Location:

Chr 4: 158361186-158506677

Description:

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated ca...

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Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  CTTTGTA_MIR524 ,  GCTTGAA_MIR498 ,  CATGTAA_MIR496 ,  TGCCTTA_MIR124A ,  TAATAAT_MIR126 ,  GTGCCTT_MIR506 ,  GTTATAT_MIR410 ,  GTGGTGA_MIR197 ,  TACAATC_MIR508 ,  AAGCACA_MIR218 ,  CTCCAAG_MIR432

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-335 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-486

miRNA binding sites
(Source: miRecords):

hsa-miR-181b Targeted Genes

Cytogenetic Map:

4q32.1

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