QuickView for HTR2C;jsessionid=1F04916CD54255F505AC99AFC6D21570;jsessionid=E3FBAF90DBA476911FE2378CB3D92843 (gene)

Gene Symbol:

Htr2c Rattus norvegicus

Full name:

5-hydroxytryptamine receptor 2C

Synonyms:

5-HT2C, 5-HTR2C, 5HT-1C, 5-hydroxytryptamine receptor 2C, 5-HT-1C, 5-HT1C, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled, 5-hydroxytryptamine receptor 1C, serotonin 1c receptor, serotonin receptor 2C

Genomic Location:

Chr X: 31015580-31132215

Description:

Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and...

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Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations.

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Orthologs:

Homo sapiens ,  Mus musculus ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MYOD_01 ,  AACTTT_UNKNOWN ,  CETS1P54_01 ,  TAL1BETAE47_01 ,  TAL1ALPHAE47_01 ,  TAL1BETAITF2_01 ,  S8_01 ,  CEBPA_01 ,  TST1_01 ,  NFY_Q6 ,  CEBP_Q2 ,  NKX25_02 ,  CHOP_01 ,  ISRE_01 ,  PAX4_02 ,  AREB6_04 ,  AFP1_Q6 ,  GCM_Q2 ,  ATF1_Q6 ,  GCCNNNWTAAR_UNKNOWN ,  CEBP_Q3 ,  IRF_Q6 ,  PIT1_Q6 ,  MYB_Q5_01 ,  E2F_Q6_01 ,  GR_01 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  AATGTGA_MIR23A_MIR23B ,  TGAGATT_MIR216 ,  TAGCTTT_MIR9 ,  GTAAGAT_MIR200A ,  CCTGCTG_MIR214 ,  GTCTACC_MIR379 ,  GGCAGTG_MIR3243P ,  TGCCTTA_MIR124A ,  TACAATC_MIR508 ,  TCATCTC_MIR143 ,  CCCAGAG_MIR326 ,  ACTGCCT_MIR34B ,  GCATTTG_MIR105 ,  CTTTGCA_MIR527 ,  TTANTCA_UNKNOWN ,  YCATTAA_UNKNOWN ,  YNGTTNNNATT_UNKNOWN ,  YTAAYNGCT_UNKNOWN ,  CAGCTG_AP4_Q5 ,  TAATTA_CHX10_01 ,  CAGGTG_E12_Q6 ,  RYTTCCTG_ETS2_B ,  GGGAGGRR_MAZ_Q6 ,  GCANCTGNY_MYOD_Q6 ,  TGCCAAR_NF1_Q6 ,  GATTGGY_NFY_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-216 ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-324-3p ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-379 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-140 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-384 ,  Predicted Gene Targets for miR-455 ,  Predicted Gene Targets for miR-485-3p ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-496

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