QuickView for Hprt1;jsessionid=F78148EDC92AF0A148EB5DFB199550D7;jsessionid=0A4720A32F6A1CFF1389E83B153BDDF9 (gene)
- Gene Symbol:
- Hprt
Mus musculus - Full name:
- hypoxanthine guanine phosphoribosyl transferase
- Synonyms:
- C81579, HPGRT, Hprt1, hypoxanthine-guanine phosphoribosyltransferase, HGPRT, HGPRTase, HPRT B, hypoxanthine guanine phosphoribosyl transferase 1
- Genomic Location:
- Chr X: 50341255-50374837
- Description:
-
The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway.
- Orthologs:
- Homo sapiens , Rattus norvegicus , C. elegans , Macaca mulatta , Bos taurus , Gallus gallus , Danio rerio , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
guanine phosphoribosyltransferase activity | cation binding | magnesium ion binding | nucleotide binding | catalytic activity | identical protein binding | transferase activity, transferring glycosyl groups | ion binding | organic cyclic compound binding | protein binding | protein homodimerization activity | protein dimerization activity | transferase activity, transferring pentosyl groups | transferase activity | hypoxanthine phosphoribosyltransferase activity | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
brain development | purine ribonucleotide metabolic process | protein homooligomerization | adaptive immune response | cell morphogenesis | purine ribonucleoside monophosphate biosynthetic process | adenine salvage | GMP metabolic process | neuron projection morphogenesis | nucleoside phosphate catabolic process | catechol-containing compound metabolic process | subpallium development | hypoxanthine biosynthetic process | cell differentiation | nervous system development | response to drug | organophosphate catabolic process | cell part morphogenesis | neurogenesis | generation of neurons | nucleoside catabolic process | phenol-containing compound metabolic process | cellular process | organic substance catabolic process | cell projection morphogenesis | nucleotide metabolic process | neuron development | central nervous system neuron differentiation | carbohydrate derivative catabolic process | cerebral cortex neuron differentiation | ribose phosphate metabolic process | purine nucleotide biosynthetic process | positive regulation of nitrogen compound metabolic process | ribonucleotide metabolic process | purine nucleoside catabolic process | regulation of cellular process | leukocyte activation | regulation of metabolic process | guanine salvage | catabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | head development | response to stimulus | purine nucleotide metabolic process | cell morphogenesis involved in neuron differentiation | hypoxanthine salvage | mononuclear cell proliferation | cellular nitrogen compound biosynthetic process | GMP catabolic process | purine nucleobase biosynthetic process | cellular nitrogen compound metabolic process | regulation of dopamine metabolic process | purine nucleotide salvage | carbohydrate derivative biosynthetic process | cellular component assembly | cellular biosynthetic process | purine nucleoside metabolic process | nucleobase-containing compound catabolic process | dopamine metabolic process | purine nucleoside monophosphate catabolic process | nucleotide biosynthetic process | regulation of catecholamine metabolic process | organic hydroxy compound metabolic process | response to nitrogen compound | central nervous system neuron development | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | system development | nitrogen compound metabolic process | multicellular organism development | phosphorus metabolic process | ribonucleoside monophosphate biosynthetic process | purine ribonucleoside catabolic process | protein complex oligomerization | leukocyte mediated immunity | telencephalon development | cell killing | organophosphate metabolic process | nucleoside metabolic process | positive regulation of cellular metabolic process | positive regulation of dopamine metabolic process | nucleobase-containing small molecule catabolic process | striatum development | pigment biosynthetic process | regulation of nitrogen compound metabolic process | small molecule metabolic process | adenine metabolic process | protein homotetramerization | nucleobase-containing small molecule metabolic process | cell proliferation | leukocyte proliferation | biosynthetic process | locomotory behavior | aromatic compound biosynthetic process | purine ribonucleotide biosynthetic process | nucleotide catabolic process | protein tetramerization | response to toxic substance | response to xenobiotic stimulus | cell morphogenesis involved in differentiation | phosphate-containing compound metabolic process | regulation of cellular metabolic process | T cell mediated immunity | purine ribonucleoside salvage | aromatic compound catabolic process | GMP biosynthetic process | drug metabolic process | lymphocyte activation | neuron differentiation | protein-containing complex assembly | response to organic substance | T cell mediated cytotoxicity | catecholamine metabolic process | anatomical structure development | response to amine | cell projection organization | metabolic process | behavior | immune response | leukocyte mediated cytotoxicity | nucleobase-containing compound metabolic process | neuron projection development | organic substance metabolic process | grooming behavior | pigment metabolic process | animal organ development | forebrain development | GMP salvage | hypoxanthine metabolic process | adenine biosynthetic process | IMP biosynthetic process | purine-containing compound salvage | cell activation | dendrite morphogenesis | organonitrogen compound catabolic process | lymphocyte proliferation | ribose phosphate biosynthetic process | cell development | anatomical structure morphogenesis | dendrite development | developmental process | purine nucleobase metabolic process | carbohydrate derivative metabolic process | response to organonitrogen compound | heterocycle metabolic process | central nervous system development | positive regulation of metabolic process | response to amphetamine | purine ribonucleotide catabolic process | IMP salvage | immune system process | cellular metabolic process | IMP metabolic process | nucleoside monophosphate biosynthetic process | guanine metabolic process | purine nucleotide catabolic process | multicellular organismal process
GO Cellular Component
cell | cytoplasm | cytosol | intracellular
