QuickView for IGF2;jsessionid=6CCE3E786A1BCA8EEBBD350DCA626716;jsessionid=3FEE7814EDB0DE47ABC55806B1362035 (gene)

Gene Symbol:

Igf2 Mus musculus

Full name:

insulin-like growth factor 2

Synonyms:

AL033362, Igf-2, Igf-II, M6pr, Mpr, Peg2, insulin-like growth factor II, multiplication-stimulating polypeptide

Genomic Location:

Chr 7: 149836673-149845394

Description:

This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. It is an imprinted gene that is expressed only from the paternal allele. The encoded protein undergoes proteolytic processing to generate a mature peptide. The transgenic overexpression of this g...

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This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. It is an imprinted gene that is expressed only from the paternal allele. The encoded protein undergoes proteolytic processing to generate a mature peptide. The transgenic overexpression of this gene in mice results in prenatal overgrowth, polyhydramnios, fetal and neonatal lethality, disproportionate organ overgrowth including tongue enlargement, and skeletal abnormalities. Mice lacking the encoded protein exhibit growth deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PBX1_02 ,  GATA1_03 ,  MYOD_Q6 ,  LMO2COM_01 ,  AREB6_03 ,  E12_Q6 ,  E2A_Q2 ,  MYOD_Q6_01 ,  ATGTCAC_MIR489 ,  CAGGTG_E12_Q6 ,  GGGAGGRR_MAZ_Q6 ,  GGGTGGRR_PAX4_03 ,  GGGCGGR_SP1_Q6

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