QuickView for IKBKB;jsessionid=367498BD01E92CD6FC4ADD35C07C6319;jsessionid=6408F07BC4D1723F9E417E4A95722FFE (gene)
- Gene Symbol:
- Ikbkb
Rattus norvegicus - Full name:
- inhibitor of nuclear factor kappa B kinase subunit beta
- Synonyms:
- AIM-1, IKK2, inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B kinase 2, I-kappa-B-kinase beta, IKK-B, IKK-beta, NFKBIKB, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, inhibitor of kappaB kinase beta, inhibitor of nuclear factor kappa B kinase beta subunit, nuclear factor NF-kappa-B inhibitor kinase beta
- Genomic Location:
- Chr 16: 73805082-73858086
- Description:
-
kinase that may be involved in megakaryocyte polyploidization
- Orthologs:
- Homo sapiens , Mus musculus , D. melanogaster , Macaca mulatta , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
kinase binding | protein kinase binding | enzyme binding | IkappaB kinase activity | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | identical protein binding | protein heterodimerization activity | scaffold protein binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | protein homodimerization activity | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
leukocyte homeostasis | multicellular organismal movement | positive regulation of macromolecule biosynthetic process | regulation of dephosphorylation | actin filament-based process | response to cytokine | response to interleukin-1 | positive regulation of cellular component organization | regulation of neurogenesis | positive regulation of ion transmembrane transporter activity | response to lipopolysaccharide | protein localization to cell periphery | intracellular signal transduction | regulation of cell development | regulation of localization | positive regulation of DNA-binding transcription factor activity | regulation of sodium ion transport | peptidyl-amino acid modification | actin cytoskeleton organization | negative regulation of cellular process | positive regulation of developmental process | regulation of phosphatase activity | cellular response to tumor necrosis factor | cell differentiation | nervous system development | response to drug | neurogenesis | positive regulation of cation channel activity | generation of neurons | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | musculoskeletal movement | localization | neuron development | I-kappaB phosphorylation | macromolecule localization | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | regulation of myosin-light-chain-phosphatase activity | negative regulation of cellular metabolic process | regulation of cell differentiation | IkappaB kinase activity | regulation of cellular process | regulation of metabolic process | regulation of bicellular tight junction assembly | cortical actin cytoskeleton organization | negative regulation of phosphatase activity | cellular component organization | muscle contraction | response to stimulus | positive regulation of cation transmembrane transport | regulation of cell proliferation | regulation of epithelial cell differentiation | protein serine/threonine kinase activity | cellular localization | response to molecule of bacterial origin | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | macromolecule modification | regulation of nucleic acid-templated transcription | response to external biotic stimulus | system development | nitrogen compound metabolic process | negative regulation of phosphate metabolic process | positive regulation of neuron projection development | multicellular organism development | negative regulation of catalytic activity | phosphorus metabolic process | response to fatty acid | regulation of catalytic activity | regulation of phosphorylation | protein localization to plasma membrane | regulation of neuron differentiation | regulation of gene expression | protein localization to membrane | response to lipid | positive regulation of cellular metabolic process | positive regulation of ion transmembrane transport | regulation of nitrogen compound metabolic process | interleukin-1-mediated signaling pathway | positive regulation of cell projection organization | cytokine-mediated signaling pathway | regulation of transcription by RNA polymerase II | B cell homeostasis | positive regulation of cell differentiation | homeostasis of number of cells | cellular response to cytokine stimulus | regulation of cellular protein metabolic process | phosphorylation | positive regulation of neuron death | response to toxic substance | protein phosphorylation | phosphate-containing compound metabolic process | negative regulation of protein dephosphorylation | response to bacterium | cell communication | regulation of cellular metabolic process | regulation of establishment of endothelial barrier | lymphocyte homeostasis | positive regulation of transporter activity | regulation of protein metabolic process | homeostatic process | positive regulation of cell proliferation | regulation of RNA metabolic process | positive regulation of transport | striated muscle contraction | positive regulation of molecular function | neuron differentiation | negative regulation of bicellular tight junction assembly | protein metabolic process | response to organic substance | regulation of protein dephosphorylation | regulation of DNA-binding transcription factor activity | anatomical structure development | cell surface receptor signaling pathway | positive regulation of neurogenesis | cell projection organization | metabolic process | positive regulation of cell development | regulation of RNA biosynthetic process | cellular protein localization | positive regulation of cell death | protein kinase activity | neuron projection development | organic substance metabolic process | negative regulation of myosin-light-chain-phosphatase activity | positive regulation of ion transport | positive regulation of sodium ion transport | negative regulation of cellular protein metabolic process | positive regulation of NF-kappaB transcription factor activity | tumor necrosis factor-mediated signaling pathway | regulation of phosphate metabolic process | cytoskeleton organization | regulation of ion transmembrane transport | negative regulation of protein metabolic process | negative regulation of molecular function | signaling | regulation of transcription, DNA-templated | cell development | skeletal muscle contraction | I-kappaB kinase/NF-kappaB signaling | regulation of transmembrane transporter activity | protein localization | regulation of ion transmembrane transporter activity | cellular protein metabolic process | negative regulation of phosphoprotein phosphatase activity | cellular macromolecule localization | response to biotic stimulus | regulation of nervous system development | regulation of developmental process | regulation of ion transport | regulation of phosphoprotein phosphatase activity | kinase activity | developmental process | organelle organization | cellular response to interleukin-1 | peptidyl-serine phosphorylation | cellular protein modification process | cortical cytoskeleton organization | regulation of cell junction assembly | regulation of transport | positive regulation of transcription, DNA-templated | regulation of endothelial cell differentiation | regulation of cation channel activity | positive regulation of nucleic acid-templated transcription | negative regulation of dephosphorylation | positive regulation of transcription by RNA polymerase II | negative regulation of hydrolase activity | positive regulation of metabolic process | positive regulation of neuron differentiation | regulation of cell projection organization | immune system process | cellular metabolic process | response to tumor necrosis factor | cellular response to organic substance | regulation of cell death | regulation of cellular component organization | muscle system process | response to other organism | signal transduction | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | cytoplasmic side of plasma membrane | intracellular membrane-bounded organelle | catalytic complex | protein kinase complex | CD40 receptor complex | cell | cytoplasmic side of membrane | plasma membrane protein complex | intrinsic component of membrane | cytoplasm | intracellular organelle | receptor complex | membrane microdomain | IkappaB kinase complex | protein-containing complex | plasma membrane | membrane raft | transferase complex | integral component of plasma membrane | serine/threonine protein kinase complex | membrane-bounded organelle | nucleus | organelle | cell periphery | cytosol | intracellular | membrane | intrinsic component of plasma membrane
