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QuickView for IL6;jsessionid=5E2DA6E31B18647F822F546D0FBFA7EE;jsessionid=471A797C99A963E828D2B9A450C03C33 (gene)


Gene Symbol:
Il6 Mus musculus Mus musculus
Full name:
interleukin 6
Synonyms:
Il-6, interleukin-6, B-cell hybridoma growth factor, interleukin HP-1
Genomic Location:
Chr 5: 30339701-30346508
Description:
This gene encodes a member of the interleukin family of cytokines that have important functions in immune response, hematopoiesis, inflammation and the acute phase response. The ectopic overexpression of the encoded protein in mice results in excessive plasma cells in circulation, leading to death. Mice lacking the encoded protein exhibit abnormali...
Orthologs:
Homo sapiens Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):


Transcripts Names
NM_031168
NM_001314054



GO Molecular Function

signaling receptor binding | cytokine receptor binding | molecular function regulator | protein binding | receptor regulator activity | growth factor activity | receptor ligand activity | cytokine activity | growth factor receptor binding | interleukin-6 receptor binding

GO Biological Process

positive regulation of immune response | leukocyte homeostasis | positive regulation of smooth muscle cell proliferation | regulation of ERK1 and ERK2 cascade | regulation of T cell mediated immunity | negative regulation of phosphorylation | adaptive immune response | positive regulation of macromolecule biosynthetic process | regulation of cysteine-type endopeptidase activity | regulation of intracellular protein transport | response to virus | CD4-positive, alpha-beta T cell differentiation | regulation of transmission of nerve impulse | response to cytokine | response to interleukin-1 | positive regulation of cellular component organization | regulation of B cell activation | regulation of cell morphogenesis | regulation of neurogenesis | CD4-positive, alpha-beta T cell activation | response to lipopolysaccharide | regulation of cellular localization | negative regulation of peptide secretion | interleukin-6-mediated signaling pathway | positive regulation of apoptotic process | regulation of cell development | regulation of localization | negative regulation of collagen biosynthetic process | morphogenesis of an epithelium | positive regulation of DNA-binding transcription factor activity | regulation of carbohydrate metabolic process | regulation of programmed cell death | hormone secretion | positive regulation of peptidyl-tyrosine phosphorylation | T cell lineage commitment | defense response to other organism | negative regulation of cysteine-type endopeptidase activity | branching involved in salivary gland morphogenesis | establishment of localization | regulation of immune system process | response to hormone | regulation of nitric oxide biosynthetic process | regulation of cell shape | neutrophil homeostasis | negative regulation of neuron death | negative regulation of cellular process | negative regulation of kinase activity | positive regulation of developmental process | cellular response to tumor necrosis factor | positive regulation of lymphocyte activation | T-helper cell lineage commitment | regulation of protein import | cell differentiation | positive regulation of epithelial cell proliferation | negative regulation of tissue remodeling | regulation of T cell differentiation | defense response | nervous system development | response to drug | negative regulation of protein phosphorylation | neurogenesis | glucose homeostasis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | negative regulation of protein secretion | positive regulation of T-helper 2 cell cytokine production | regulation of DNA replication | generation of neurons | positive regulation of protein secretion | response to antibiotic | salivary gland morphogenesis | negative regulation of proteolysis | positive regulation of T cell differentiation | regulation of circadian sleep/wake cycle | regulation of bone remodeling | regulation of neuron death | positive regulation of neurological system process | positive regulation of cellular biosynthetic process | regulation of immunoglobulin secretion | cellular process | secretion | negative regulation of muscle organ development | peptide hormone secretion | lymphocyte differentiation | T-helper 17 cell differentiation | regulation of cytokine biosynthetic process | localization | cellular homeostasis | negative regulation of signaling | negative regulation of gluconeogenesis | positive regulation of immune effector process | positive regulation of peptidyl-serine phosphorylation | neuron development | positive regulation of reactive oxygen species metabolic process | positive regulation of adaptive immune response | immune system development | cellular response to hepatocyte growth factor stimulus | regulation of response to cytokine stimulus | negative regulation of apoptotic process | negative regulation of secretion | regulation of proteolysis | response to growth factor | regulation of tyrosine phosphorylation of STAT protein | positive regulation of nitrogen compound metabolic process | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment | regulation of neuron projection development | negative regulation of hormone secretion | response to inorganic substance | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | regulation of behavior | tissue development | regulation of neurological system process | regulation of cell differentiation | anatomical structure homeostasis | response to hydrogen peroxide | regulation of protein kinase B signaling | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | negative regulation of cytokine secretion | T cell differentiation involved in immune response | cellular response to molecule of bacterial origin | positive regulation of translation | regulation of type 2 immune response | positive regulation of cellular protein metabolic process | epithelium development | positive regulation of T cell cytokine production | endocrine pancreas development | negative regulation of bone resorption | cellular component organization | T cell activation | inflammatory cell apoptotic process | regulation of peptide secretion | response to stimulus | negative regulation of protein transport | regulation of cellular protein localization | alpha-beta T cell activation involved in immune response | regulation of peptidyl-tyrosine phosphorylation | positive regulation of nitric oxide metabolic process | positive regulation of immune system process | positive regulation of protein metabolic process | regulation of CD4-positive, alpha-beta T cell activation | positive regulation of immunoglobulin production | gland morphogenesis | response to stress | positive regulation of JAK-STAT cascade | cell redox homeostasis | leukocyte activation involved in immune response | negative regulation of protein kinase activity | positive regulation of cellular protein localization | positive regulation of lymphocyte proliferation | posttranscriptional regulation of gene expression | regulation of cell proliferation | T-helper 17 cell lineage commitment | positive regulation of cell-cell adhesion | programmed cell death | positive regulation of cell activation | secretion by cell | response to molecule of bacterial origin | cellular response to toxic substance | positive regulation of T cell activation | negative regulation of transport | regulation of protein transport | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | regulation of circadian sleep/wake cycle, non-REM sleep | regulation of peptide transport | regulation of cell adhesion | cell-cell signaling | regulation of intracellular transport | molecular function regulator | negative regulation of interleukin-1-mediated signaling pathway | regulation of lymphocyte differentiation | myeloid cell homeostasis | regulation of nucleic acid-templated transcription | T-helper cell differentiation | positive regulation of peptide secretion | regulation of membrane potential | leukocyte differentiation | regulation of neurotransmitter levels | apoptotic process | cellular response to interleukin-6 | positive regulation of reactive oxygen species biosynthetic process | positive regulation of mononuclear cell proliferation | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | response to external biotic stimulus | system development | regulation of signal transduction | negative regulation of secretion by cell | negative regulation of phosphate metabolic process | positive regulation of neuron projection development | cellular response to antibiotic | multicellular organism development | negative regulation of catalytic activity | positive regulation of lymphocyte differentiation | regulation of peptidase activity | positive regulation of DNA replication | regulation of MAPK cascade | regulation of collagen biosynthetic process | positive regulation of inflammatory response | positive regulation of protein kinase B signaling | regulation of catalytic activity | cellular response to oxidative stress | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | regulation of CD4-positive, alpha-beta T cell differentiation | negative regulation of peptidase activity | regulation of acute inflammatory response | regulation of T cell activation | positive regulation of alpha-beta T cell differentiation | regulation of neuron differentiation | regulation of gene expression | pancreas development | positive regulation of secretion | negative regulation of chemokine production | organic substance transport | cellular response to stress | response to lipid | alpha-beta T cell lineage commitment | positive regulation of intracellular protein transport | negative regulation of cytokine production | regulation of protein import into nucleus, translocation | positive regulation of cellular metabolic process | defense response to virus | positive regulation of protein phosphorylation | regulation of lymphocyte activation | animal organ morphogenesis | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of cell projection organization | positive regulation of STAT cascade | peptide transport | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | response to corticosteroid | glucagon secretion | positive regulation of T-helper 2 cell differentiation | regulation of transcription by RNA polymerase II | alpha-beta T cell differentiation | response to oxidative stress | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of cell proliferation in bone marrow | positive regulation of cell differentiation | acute-phase response | regulation of T cell cytokine production | homeostasis of number of cells | cellular response to cytokine stimulus | cell proliferation | positive regulation of protein localization to nucleus | regulation of cellular protein metabolic process | positive regulation of T cell proliferation | muscle cell cellular homeostasis | T cell activation involved in immune response | positive regulation of chemokine production | response to toxic substance | negative regulation of membrane potential | regulation of circadian sleep/wake cycle, sleep | endocrine system development | defense response to protozoan | negative regulation of cytokine biosynthetic process | cellular response to drug | response to hepatocyte growth factor | response to bacterium | peptide secretion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of tyrosine phosphorylation of STAT protein | regulation of alpha-beta T cell differentiation | inflammatory response | cell activation involved in immune response | regulation of cytokine production involved in immune response | regulation of collagen metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of cytokine-mediated signaling pathway | regulation of RNA metabolic process | positive regulation of B cell activation | positive regulation of transport | lymphocyte activation | positive regulation of molecular function | regulation of nucleocytoplasmic transport | regulation of cytokine secretion | neuron differentiation | hepatic immune response | T cell differentiation | regulation of signaling receptor activity | receptor regulator activity | negative regulation of carbohydrate metabolic process | regulation of establishment of protein localization | positive regulation of type 2 immune response | positive regulation of T-helper cell differentiation | positive regulation of protein modification process | T cell selection | response to organic substance | gland development | tissue morphogenesis | regulation of protein import into nucleus | regulation of hemopoiesis | positive regulation of transmission of nerve impulse | epithelial cell proliferation | regulation of JAK-STAT cascade | regulation of kinase activity | response to wounding | regulation of interleukin-1-mediated signaling pathway | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | positive regulation of neurogenesis | negative regulation of response to cytokine stimulus | regulation of glucose metabolic process | growth factor activity | cell projection organization | positive regulation of cell development | cell fate commitment | regulation of adaptive immune response | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | negative regulation of programmed cell death | positive regulation of cytokine production involved in immune response | regulation of bone resorption | positive T cell selection | regulation of tissue remodeling | amide transport | cellular response to hydrogen peroxide | chemical homeostasis | regulation of secretion | positive regulation of cell death | receptor ligand activity | positive regulation of interleukin-6 production | immune response | hormone transport | cellular response to reactive oxygen species | neuron projection development | cytokine activity | neutrophil apoptotic process | positive regulation of acute inflammatory response | cell death | negative regulation of biosynthetic process | animal organ development | response to reactive oxygen species | negative regulation of cellular protein metabolic process | regulation of cell activation | regulation of protein secretion | positive regulation of ERK1 and ERK2 cascade | positive regulation of programmed cell death | response to protozoan | alpha-beta T cell activation | regulation of phosphate metabolic process | positive regulation of cytokine production | positive regulation of intracellular transport | cell activation | positive regulation of MAPK cascade | positive regulation of T cell mediated immunity | morphogenesis of a branching epithelium | positive regulation of protein transport | regulation of reactive oxygen species biosynthetic process | regulation of peptidyl-serine phosphorylation | regulation of T-helper cell differentiation | negative regulation of protein metabolic process | positive regulation of protein import into nucleus, translocation | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of immunoglobulin production | regulation of transcription, DNA-templated | response to organic cyclic compound | cell development | regulation of T cell proliferation | positive regulation of CD4-positive, alpha-beta T cell differentiation | regulation of epithelial cell proliferation | positive regulation of phosphorylation | regulation of cytokine production | morphogenesis of a branching structure | anatomical structure morphogenesis | regulation of endopeptidase activity | positive regulation of protein import into nucleus | response to biotic stimulus | regulation of circadian rhythm | regulation of nervous system development | regulation of developmental process | positive regulation of DNA metabolic process | epithelial cell proliferation involved in salivary gland morphogenesis | positive regulation of immunoglobulin secretion | developmental process | positive regulation of alpha-beta T cell activation | positive regulation of protein import | cellular response to interleukin-1 | regulation of chemokine production | myeloid cell apoptotic process | regulation of transport | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | negative regulation of cell proliferation | regulation of cell-cell adhesion | positive regulation of nucleic acid-templated transcription | signal release | positive regulation of transcription by RNA polymerase II | negative regulation of cytokine-mediated signaling pathway | regulation of vascular endothelial growth factor production | negative regulation of hydrolase activity | regulation of gluconeogenesis | positive regulation of nitric oxide biosynthetic process | negative regulation of bone remodeling | positive regulation of metabolic process | positive regulation of neuron differentiation | regulation of cell projection organization | acute inflammatory response | immune system process | hematopoietic or lymphoid organ development | response to tumor necrosis factor | cellular response to organic substance | regulation of protein localization | exocrine system development | regulation of cell death | regulation of smooth muscle cell proliferation | salivary gland development | response to steroid hormone | regulation of translation | negative regulation of chemokine biosynthetic process | positive regulation of CD4-positive, alpha-beta T cell activation | response to interleukin-6 | negative regulation of cell death | regulation of interleukin-6 production | regulation of inflammatory response | carbohydrate homeostasis | positive regulation of nucleocytoplasmic transport | positive regulation of leukocyte cell-cell adhesion | regulation of cellular component organization | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | negative regulation of endopeptidase activity | positive regulation of gene expression | response to glucocorticoid | cellular response to growth factor stimulus | cellular response to lipopolysaccharide | regulation of muscle organ development | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

integral component of membrane | cell | plasma membrane protein complex | intrinsic component of membrane | external side of plasma membrane | cytoplasm | receptor complex | protein-containing complex | plasma membrane | integral component of plasma membrane | extracellular region | interleukin-6 receptor complex | extracellular space | cell periphery | cell surface | intracellular | membrane | intrinsic component of plasma membrane