QuickView for Isl1;jsessionid=3C02D692BEF1FA3F66DDFC24760D07A2;jsessionid=C561E5350CE1B3F4630BFA30B1A9DBB3 (gene)
- Gene Symbol:
- Isl1
Rattus norvegicus - Full name:
- ISL LIM homeobox 1
- Synonyms:
- Isl-1, isl-1=homeobox, insulin gene enhancer protein ISL-1, ISL1 transcription factor LIM/homeodomain (islet-1), ISL1 transcription factor, LIM/homeodomain 1, isl-1 homeobox, islet-1
- Genomic Location:
- Chr 2: 48050124-48060394
- Description:
-
transcription factor; may regulate insulin gene expression or islet cell development
- Orthologs:
- Homo sapiens , Mus musculus , D. melanogaster , C. elegans , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-128 , Predicted Gene Targets for miR-132 , Predicted Gene Targets for miR-219 , Predicted Gene Targets for miR-23 , Predicted Gene Targets for miR-27 , Predicted Gene Targets for miR-325 , Predicted Gene Targets for miR-382 , Predicted Gene Targets for miR-9 , Predicted Gene Targets for miR-96 , Predicted Gene Targets for miR-182
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | enhancer binding | cation binding | hormone receptor binding | proximal promoter sequence-specific DNA binding | RNA polymerase II activating transcription factor binding | nucleic acid binding | estrogen receptor binding | signaling receptor binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | chromatin binding | enhancer sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | bHLH transcription factor binding | DNA binding | sequence-specific double-stranded DNA binding | promoter-specific chromatin binding | nuclear hormone receptor binding | ion binding | organic cyclic compound binding | transcription coactivator activity | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II transcription factor binding | activating transcription factor binding | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nuclear receptor binding | steroid hormone receptor binding | transcription coregulator activity | metal ion binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | brain development | regulation of interleukin-1 beta production | cell morphogenesis | ventricular cardiac muscle tissue morphogenesis | positive regulation of macromolecule biosynthetic process | positive regulation of cellular component organization | cell motility | pharyngeal system development | regulation of neurogenesis | neuron projection morphogenesis | muscle tissue development | regulation of cell development | regulation of localization | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | spinal cord motor neuron differentiation | response to hormone | negative regulation of neuron death | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | cell differentiation | nervous system development | cell part morphogenesis | neurogenesis | positive regulation of phosphate metabolic process | regulation of organelle organization | regulation of peptide hormone secretion | generation of neurons | positive regulation of protein secretion | mesenchyme development | cardiac atrium morphogenesis | pattern specification process | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | cell fate specification | peripheral nervous system development | negative regulation of inflammatory response | localization | cell projection morphogenesis | negative regulation of protein homodimerization activity | heart morphogenesis | negative regulation of signaling | neuron development | central nervous system neuron differentiation | positive regulation of epithelial to mesenchymal transition | negative regulation of nucleic acid-templated transcription | positive regulation of macrophage colony-stimulating factor production | regulation of histone modification | negative regulation of apoptotic process | axon guidance | regulation of tyrosine phosphorylation of STAT protein | positive regulation of nitrogen compound metabolic process | diencephalon development | regulation of canonical Wnt signaling pathway | negative regulation of cellular metabolic process | tissue development | regulation of binding | regulation of cell differentiation | muscle structure development | regeneration | regulation of angiogenesis | positive regulation of granulocyte macrophage colony-stimulating factor production | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | pituitary gland development | cardiac cell fate determination | positive regulation of interferon-gamma production | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | positive regulation of tumor necrosis factor production | head development | cranial nerve development | sensory system development | regulation of peptide secretion | muscle organ morphogenesis | spinal cord motor neuron cell fate specification | regulation of vasculature development | response to stimulus | positive regulation of interleukin-1 beta production | cardiac right ventricle morphogenesis | cell morphogenesis involved in neuron differentiation | mesenchymal cell development | regulation of peptidyl-tyrosine phosphorylation | regulation of insulin secretion | positive regulation of protein metabolic process | regulation of cardioblast proliferation | response to stress | neuron projection guidance | regulation of intracellular steroid hormone receptor signaling pathway | positive regulation of JAK-STAT cascade | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | cardiac muscle tissue development | muscle tissue morphogenesis | regulation of protein homodimerization activity | positive regulation of vascular endothelial growth factor production | cardiac ventricle morphogenesis | heart formation | cellular nitrogen compound metabolic process | retinal ganglion cell axon guidance | positive regulation of hormone secretion | regulation of DNA binding | cellular response to organic cyclic compound | regulation of protein transport | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | regulation of peptide transport | cellular biosynthetic process | embryo development | neuron fate commitment | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | locomotion | negative regulation of neuron apoptotic process | cellular response to hormone stimulus | endocardial cushion development | system development | ventral spinal cord development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | peripheral nervous system neuron axonogenesis | multicellular organism development | positive regulation of granulocyte colony-stimulating factor production | cell migration | regulation of intracellular estrogen receptor signaling pathway | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | positive regulation of chromosome organization | positive regulation of interleukin-1 alpha production | regulation of neuron differentiation | regulation of gene expression | pancreas development | axon development | positive regulation of secretion | outflow tract morphogenesis | cellular response to stress | response to lipid | endocardial cushion morphogenesis | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | response to axon injury | animal organ morphogenesis | specification of animal organ identity | regulation of nitrogen compound metabolic process | cardiac atrium development | positive regulation of STAT cascade | positive regulation of interleukin-12 production | positive regulation of intracellular signal transduction | cardiocyte differentiation | response to corticosteroid | regulation of transcription by RNA polymerase II | axonogenesis | negative regulation of binding | positive regulation of cell differentiation | stem cell differentiation | negative regulation of intracellular steroid hormone receptor signaling pathway | regulation of cell proliferation involved in heart morphogenesis | biosynthetic process | innervation | neuron projection regeneration | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | cellular response to glucocorticoid stimulus | mesenchyme morphogenesis | cardiac septum morphogenesis | endocrine system development | regulation of tumor necrosis factor production | cell morphogenesis involved in differentiation | cellular response to corticosteroid stimulus | neural crest cell migration | regulation of interleukin-1 production | chordate embryonic development | animal organ formation | striated muscle tissue development | cardiac muscle tissue morphogenesis | negative regulation of protein binding | regulation of cellular metabolic process | regulation of neuron apoptotic process | positive regulation of interleukin-1 production | regulation of macrophage colony-stimulating factor production | positive regulation of tyrosine phosphorylation of STAT protein | visceral motor neuron differentiation | regulation of protein metabolic process | positive regulation of signal transduction | heart development | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | embryo development ending in birth or egg hatching | transcription coactivator activity | regulation of RNA metabolic process | positive regulation of protein acetylation | positive regulation of transport | positive regulation of peptide hormone secretion | negative regulation of intracellular estrogen receptor signaling pathway | positive regulation of molecular function | neuron differentiation | negative regulation of epithelial cell proliferation | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | regulation of establishment of protein localization | regionalization | cardiac ventricle development | positive regulation of protein modification process | response to organic substance | gland development | positive regulation of insulin secretion | tissue morphogenesis | regulation of JAK-STAT cascade | response to wounding | regulation of animal organ morphogenesis | regulation of intracellular signal transduction | positive regulation of peptidyl-lysine acetylation | ventricular cardiac muscle tissue development | anatomical structure development | cell projection organization | metabolic process | cell fate commitment | mesenchymal cell differentiation | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | peripheral nervous system neuron development | regulation of secretion | heart field specification | positive regulation of interleukin-6 production | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | neuron projection development | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | positive regulation of histone modification | forebrain development | negative regulation of neuron differentiation | nerve development | gene expression | regulation of protein secretion | regulation of heart morphogenesis | regulation of Wnt signaling pathway | regulation of phosphate metabolic process | regulation of chromosome organization | cellular response to steroid hormone stimulus | positive regulation of binding | transcription, DNA-templated | positive regulation of cytokine production | atrial septum development | stem cell development | positive regulation of protein transport | anatomical structure formation involved in morphogenesis | cell differentiation in spinal cord | regulation of animal organ formation | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | regulation of transcription, DNA-templated | regulation of protein binding | response to organic cyclic compound | regulation of secondary heart field cardioblast proliferation | myoblast differentiation | cell development | positive regulation of DNA binding | regulation of epithelial cell proliferation | positive regulation of phosphorylation | cardioblast differentiation | regulation of cytokine production | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | trigeminal nerve development | axon regeneration | regulation of nervous system development | regulation of developmental process | developmental process | negative regulation of canonical Wnt signaling pathway | cardiac septum development | regulation of histone acetylation | negative regulation of transcription by RNA polymerase II | positive regulation of histone acetylation | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | cardiac muscle cell myoblast differentiation | atrial septum morphogenesis | positive regulation of nucleic acid-templated transcription | cell fate determination | neural crest cell differentiation | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | regulation of epithelial to mesenchymal transition | secondary heart field specification | cardiac chamber development | heterocycle metabolic process | regulation of vascular endothelial growth factor production | central nervous system development | spinal cord development | positive regulation of metabolic process | negative regulation of Wnt signaling pathway | regulation of interferon-gamma production | cellular metabolic process | ameboidal-type cell migration | cellular response to organic substance | regulation of protein localization | regulation of cell death | response to steroid hormone | peripheral nervous system neuron differentiation | negative regulation of cell death | negative regulation of cell development | regulation of interleukin-6 production | neuron fate specification | circulatory system development | regulation of inflammatory response | chemotaxis | neural crest cell development | positive regulation of angiogenesis | negative regulation of cell differentiation | regulation of cellular component organization | muscle organ development | positive regulation of signaling | regulation of signaling | positive regulation of gene expression | response to glucocorticoid | outflow tract septum morphogenesis | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process | regulation of chromatin organization | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
