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QuickView for JAP3;jsessionid=D5C9FF1372DE4F88E2279A60F7476D46;jsessionid=637DA17A772F14247C613FC9A4146B8F (gene)


Gene Symbol:
Arntl Rattus norvegicus Rattus norvegicus
Full name:
aryl hydrocarbon receptor nuclear translocator-like
Synonyms:
Bmal1, aryl hydrocarbon receptor nuclear translocator-like protein 1, brain and muscle ARNT-like 1, tic
Genomic Location:
Chr 1: 171062181-171162426
Description:
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with Clock. This heterodimer binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by inte...
Orthologs:
Homo sapiens Mus musculus D. melanogaster Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):





GO Molecular Function

sequence-specific DNA binding | transcription factor activity, transcription factor binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | aryl hydrocarbon receptor binding | enhancer binding | repressing transcription factor binding | transcription factor activity, RNA polymerase II transcription factor binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | signaling receptor binding | enhancer sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | E-box binding | bHLH transcription factor binding | DNA binding | sequence-specific double-stranded DNA binding | protein heterodimerization activity | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | transcriptional activator activity, RNA polymerase II transcription factor binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | DNA-binding transcription factor activity | transcription factor binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | RNA polymerase II distal enhancer sequence-specific DNA binding | Hsp90 protein binding | heat shock protein binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | negative regulation of TOR signaling | positive regulation of circadian rhythm | transcription factor activity, transcription factor binding | positive regulation of macromolecule biosynthetic process | regulation of neurogenesis | positive regulation of skeletal muscle tissue development | proteolysis | regulation of cell development | regulation of localization | positive regulation of striated muscle tissue development | regulation of cell aging | establishment of localization | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | cell differentiation | male gamete generation | negative regulation of fat cell differentiation | nervous system development | neurogenesis | regulation of peptide hormone secretion | generation of neurons | intracellular transport | regulation of skeletal muscle cell differentiation | positive regulation of cellular biosynthetic process | cellular process | positive regulation of skeletal muscle cell differentiation | organic substance catabolic process | circadian regulation of gene expression | localization | proteolysis involved in cellular protein catabolic process | protein transport | negative regulation of signaling | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | regulation of striated muscle tissue development | macromolecule localization | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | transcription factor activity, RNA polymerase II transcription factor binding | regulation of canonical Wnt signaling pathway | establishment of localization in cell | negative regulation of cellular metabolic process | regulation of fat cell differentiation | regulation of cell differentiation | gamete generation | regulation of cellular process | parturition | regulation of metabolic process | catabolic process | protein import into nucleus | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | negative regulation of glucocorticoid receptor signaling pathway | regulation of peptide secretion | stress-induced premature senescence | response to stimulus | regulation of insulin secretion | positive regulation of protein metabolic process | response to stress | intracellular protein transport | regulation of intracellular steroid hormone receptor signaling pathway | cellular nitrogen compound biosynthetic process | protein localization to nucleus | circadian rhythm | regulation of epithelial cell differentiation | reproduction | cellular protein catabolic process | cellular localization | rhythmic process | cellular nitrogen compound metabolic process | proteasomal protein catabolic process | regulation of protein transport | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | regulation of peptide transport | cellular biosynthetic process | regulation of TOR signaling | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | regulation of skeletal muscle tissue development | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | multicellular organism development | protein import into nucleus, translocation | positive regulation of muscle organ development | cellular response to oxidative stress | regulation of hormone levels | regulation of hormone secretion | regulation of gene expression | organic substance transport | cellular response to stress | protein catabolic process | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | peptide transport | regulation of transcription by RNA polymerase II | response to oxidative stress | protein localization to organelle | import into nucleus | positive regulation of cell differentiation | negative regulation of intracellular steroid hormone receptor signaling pathway | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | oxidative stress-induced premature senescence | protein import | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | regulation of RNA metabolic process | positive regulation of protein acetylation | cell aging | proteasome-mediated ubiquitin-dependent protein catabolic process | transcriptional activator activity, RNA polymerase II transcription factor binding | multicellular organism reproduction | maternal process involved in parturition | protein metabolic process | DNA-binding transcription factor activity | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cellular macromolecule catabolic process | establishment of protein localization to organelle | anatomical structure development | metabolic process | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | regulation of type B pancreatic cell development | cellular protein localization | amide transport | regulation of secretion | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | nuclear transport | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | regulation of protein secretion | regulation of Wnt signaling pathway | establishment of protein localization | positive regulation of muscle tissue development | transcription, DNA-templated | positive regulation of canonical Wnt signaling pathway | ubiquitin-dependent protein catabolic process | organonitrogen compound catabolic process | regulation of cell communication | cellular senescence | negative regulation of signal transduction | regulation of transcription, DNA-templated | protein localization | cellular protein metabolic process | cellular macromolecule localization | cellular macromolecule biosynthetic process | nucleocytoplasmic transport | regulation of circadian rhythm | regulation of nervous system development | regulation of developmental process | developmental process | spermatogenesis | regulation of transport | positive regulation of transcription, DNA-templated | regulation of hair cycle | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | positive regulation of Wnt signaling pathway | cellular metabolic process | regulation of protein localization | modification-dependent protein catabolic process | aging | response to redox state | sexual reproduction | negative regulation of cell differentiation | positive regulation of signaling | regulation of signaling | positive regulation of gene expression | regulation of muscle organ development | macromolecule metabolic process | regulation of cellular senescence | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | ribonucleoprotein granule | transcription factor complex | cytoplasm | intracellular organelle | nuclear body | protein-containing complex | PML body | nucleoplasm | ribonucleoprotein complex | membrane-bounded organelle | nucleus | organelle | cytoplasmic ribonucleoprotein granule | membrane-enclosed lumen | chromatoid body | intracellular