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QuickView for KMT2A;jsessionid=902DD02C4F7792A75B273E97EBADECC6;jsessionid=FFC8D93C0FCF2ACD8150B9243F7BFEA7 (gene)


Gene Symbol:
Kmt2a Rattus norvegicus Rattus norvegicus
Full name:
lysine methyltransferase 2A
Synonyms:
Mll, Mll1, histone-lysine N-methyltransferase MLL, histone-lysine N-methyltransferase 2A, Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or trithorax Drosophila gene), Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene), lysine (K)-specific methyltransferase 2A, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila), myeloid/lymphoid or mixed-lineage leukemia 1
Genomic Location:
Chr 8: 47759168-47834580
Orthologs:
Homo sapiens Mus musculus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
AAAYRNCTG_UNKNOWN AACTTT_UNKNOWN P300_01 HEN1_02 HEN1_01 PBX1_01 PAX2_01 CDPCR1_01 CDPCR3HD_01 MYCMAX_01
miRNA binding sites
(Source: TargetScan):
Predicted Gene Targets for miR-101 Predicted Gene Targets for miR-128 Predicted Gene Targets for miR-130 Predicted Gene Targets for miR-136 Predicted Gene Targets for miR-142-3p Predicted Gene Targets for miR-148 Predicted Gene Targets for miR-150 Predicted Gene Targets for miR-193 Predicted Gene Targets for miR-218 Predicted Gene Targets for miR-221


Protein Names
No proteins found.



GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | histone-lysine N-methyltransferase activity | lysine N-methyltransferase activity | protein methyltransferase activity | enhancer binding | cation binding | nucleic acid binding | S-adenosylmethionine-dependent methyltransferase activity | unmethylated CpG binding | lysine-acetylated histone binding | catalytic activity | chromatin binding | enhancer sequence-specific DNA binding | modification-dependent protein binding | RNA polymerase II regulatory region DNA binding | histone methyltransferase activity (H3-K4 specific) | DNA binding | sequence-specific double-stranded DNA binding | identical protein binding | histone methyltransferase activity | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | protein homodimerization activity | zinc ion binding | double-stranded DNA binding | N-methyltransferase activity | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | RNA polymerase II distal enhancer sequence-specific DNA binding | transferase activity | histone binding | transition metal ion binding | protein-lysine N-methyltransferase activity | methyltransferase activity | metal ion binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | response to radiation | positive regulation of macromolecule biosynthetic process | positive regulation of cellular component organization | homeostasis of number of cells within a tissue | regulation of localization | peptidyl-amino acid modification | regulation of DNA methylation | DNA modification | negative regulation of cellular process | response to potassium ion | response to metal ion | regulation of histone H3-K14 acetylation | histone modification | histone-lysine N-methyltransferase activity | lysine N-methyltransferase activity | protein methyltransferase activity | regulation of organelle organization | tissue homeostasis | negative regulation of DNA metabolic process | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | circadian regulation of gene expression | exploration behavior | chromatin organization | visual learning | regulation of neuronal synaptic plasticity | negative regulation of DNA methylation | immune system development | learning | regulation of histone modification | positive regulation of nitrogen compound metabolic process | response to inorganic substance | negative regulation of cellular metabolic process | regulation of histone H3-K9 acetylation | anatomical structure homeostasis | regulation of cellular process | regulation of metabolic process | S-adenosylmethionine-dependent methyltransferase activity | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | histone H3-K4 trimethylation | histone H4 acetylation | associative learning | regulation of histone methylation | response to stimulus | positive regulation of protein metabolic process | cellular nitrogen compound biosynthetic process | regulation of response to drug | regulation of cell proliferation | multicellular organismal homeostasis | circadian rhythm | peptidyl-lysine acetylation | regulation of histone H3-K27 acetylation | histone H3-K4 methylation | rhythmic process | cellular nitrogen compound metabolic process | peptidyl-lysine trimethylation | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | cellular component assembly | protein modification process | modulation of chemical synaptic transmission | cellular biosynthetic process | embryo development | macromolecule modification | histone H3-K4 dimethylation | anterior/posterior pattern specification | regulation of nucleic acid-templated transcription | regulation of membrane potential | response to light stimulus | system development | nitrogen compound metabolic process | positive regulation of organelle organization | multicellular organism development | protein acetylation | histone methylation | learning or memory | spleen development | embryonic hemopoiesis | positive regulation of chromosome organization | regulation of gene expression | methylation | nervous system process | histone methyltransferase activity (H3-K4 specific) | positive regulation of cellular metabolic process | histone H4-K16 acetylation | regulation of nitrogen compound metabolic process | definitive hemopoiesis | regulation of transcription by RNA polymerase II | DNA methylation | cognition | homeostasis of number of cells | histone acetylation | internal peptidyl-lysine acetylation | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | peptidyl-lysine monomethylation | histone methyltransferase activity | peptidyl-lysine dimethylation | post-embryonic development | regulation of cellular response to drug | regulation of cellular metabolic process | positive regulation of histone H3-K4 methylation | positive regulation of response to drug | positive regulation of transporter activity | regulation of protein metabolic process | regulation of histone H3-K4 methylation | homeostatic process | regulation of RNA metabolic process | positive regulation of transport | positive regulation of molecular function | protein-containing complex assembly | protein metabolic process | regionalization | positive regulation of protein modification process | peptidyl-lysine methylation | visual behavior | DNA metabolic process | N-methyltransferase activity | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | embryonic organ development | peptidyl-lysine modification | behavior | membrane depolarization | nucleobase-containing compound metabolic process | organic substance metabolic process | histone lysine methylation | animal organ development | positive regulation of histone modification | gene expression | regulation of chromosome organization | transcription, DNA-templated | positive regulation of cellular response to drug | regulation of cell communication | covalent chromatin modification | regulation of transcription, DNA-templated | protein-lysine N-methyltransferase activity | internal protein amino acid acetylation | cellular protein metabolic process | cellular macromolecule biosynthetic process | protein methylation | methyltransferase activity | developmental process | organelle organization | cellular protein modification process | regulation of histone acetylation | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | regulation of synaptic plasticity | positive regulation of histone methylation | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | regulation of short-term neuronal synaptic plasticity | regulation of cellular component organization | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of chromatin organization

GO Cellular Component

intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | MLL1/2 complex | cytoplasm | intracellular organelle | MLL1 complex | histone methyltransferase complex | protein-containing complex | methyltransferase complex | nucleoplasm | transferase complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular