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QuickView for KRP;jsessionid=731619B62771E497F7AFE57452A8CD9F;jsessionid=E7F6F2A5F6D936FAB30A475870C11D71 (gene)


Gene Symbol:
Pcsk1 Rattus norvegicus Rattus norvegicus
Full name:
proprotein convertase subtilisin/kexin type 1
Synonyms:
BDP, PC1, PC3, neuroendocrine convertase 1, NEC 1, Protein convertase subtilisin / kexin, type I, prohormone convertase 1, prohormone convertase 3, proprotein convertase 1
Genomic Location:
Chr 2: 1923309-1970238
Description:
plays a role in proteolytic processing of peptide hormone and other protein precursors
Orthologs:
Homo sapiens Mus musculus Saccharomyces cerevisiae Macaca mulatta Danio rerio Schizosaccharomyces pombe Bos taurus Pan troglodytes Canis lupus familiaris Gallus gallus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):


Transcripts Names
NM_017091
Protein Names
P28840



GO Molecular Function

peptide binding | peptide hormone binding | protein-containing complex binding | insulin binding | hydrolase activity | catalytic activity | chaperone binding | serine hydrolase activity | amide binding | identical protein binding | hormone binding | protein binding | serine-type endopeptidase activity | serine-type peptidase activity | endopeptidase activity | peptidase activity

GO Biological Process

response to extracellular stimulus | brain development | response to nutrient levels | response to cytokine | response to interleukin-1 | response to lipopolysaccharide | proteolysis | regulation of localization | response to isoquinoline alkaloid | response to hormone | protein processing | response to metal ion | cell differentiation | nervous system development | response to drug | neurogenesis | positive regulation of protein secretion | cellular process | response to morphine | diencephalon development | response to inorganic substance | response to peptide hormone | regulation of cellular process | pituitary gland development | head development | regulation of peptide secretion | response to stimulus | peptide biosynthetic process | response to stress | cellular nitrogen compound biosynthetic process | response to peptide | response to glucose | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | regulation of protein transport | regulation of peptide transport | cellular biosynthetic process | positive regulation of peptide secretion | response to nitrogen compound | response to external biotic stimulus | system development | nitrogen compound metabolic process | multicellular organism development | response to fatty acid | regulation of hormone levels | pancreas development | positive regulation of secretion | response to lipid | response to axon injury | response to ammonium ion | response to corticosteroid | cellular amide metabolic process | biosynthetic process | protein maturation | response to xenobiotic stimulus | endocrine system development | response to bacterium | response to monosaccharide | positive regulation of establishment of protein localization | peptide metabolic process | positive regulation of transport | protein metabolic process | regulation of establishment of protein localization | response to organic substance | gland development | response to wounding | anatomical structure development | metabolic process | regulation of secretion | organic substance metabolic process | animal organ development | forebrain development | gene expression | amide biosynthetic process | regulation of protein secretion | serine-type endopeptidase activity | response to alkaloid | serine-type peptidase activity | peptide hormone processing | protein autoprocessing | positive regulation of protein transport | response to organic cyclic compound | endopeptidase activity | response to chlorate | hormone metabolic process | response to biotic stimulus | developmental process | regulation of transport | response to organonitrogen compound | response to calcium ion | central nervous system development | response to anesthetic | cellular metabolic process | peptidase activity | regulation of protein localization | response to carbohydrate | response to steroid hormone | response to other organism | response to glucocorticoid | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

secretory granule | dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | somatodendritic compartment | cytoplasmic vesicle | cell body | cell | neuronal cell body | distal axon | cytoplasmic vesicle lumen | cytoplasm | intracellular organelle | endoplasmic reticulum | dendritic tree | presynapse | Golgi apparatus | cell projection | secretory vesicle | endomembrane system | perikaryon | vesicle | transport vesicle | perinuclear region of cytoplasm | extracellular region | membrane-bounded organelle | organelle | axon terminus | extracellular space | axon | membrane-enclosed lumen | trans-Golgi network | neuron projection terminus | secretory granule lumen | rough endoplasmic reticulum | intracellular vesicle | intracellular | vesicle lumen