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QuickView for MDH;jsessionid=6E526EA1795F20D979BA8AF338567F39;jsessionid=7BB404A108041079CD16FC9BD2C508E6 (gene)


Gene Symbol:
ME1 Homo sapiens Homo sapiens
Full name:
malic enzyme 1
Synonyms:
HUMNDME, MES, NADP-dependent malic enzyme, Malic enzyme, cytoplasmic, NADP-ME, malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), malic enzyme 1, NADP(+)-dependent, cytosolic, malic enzyme 1, soluble, pyruvic-malic carboxylase
Genomic Location:
Chr 6: 83976827-84197498
Description:
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid ho...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Danio rerio Gallus gallus Canis lupus familiaris Pan troglodytes Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 6
6q14.2





GO Molecular Function

oxidoreductase activity, acting on CH-OH group of donors | ADP binding | NADP binding | cofactor binding | malic enzyme activity | cation binding | oxaloacetate decarboxylase activity | ribonucleotide binding | nucleotide binding | coenzyme binding | carbohydrate derivative binding | lyase activity | carbon-carbon lyase activity | catalytic activity | malate dehydrogenase activity | anion binding | adenyl nucleotide binding | electron transfer activity | purine nucleotide binding | carboxy-lyase activity | ion binding | organic cyclic compound binding | manganese ion binding | NAD binding | transition metal ion binding | purine ribonucleotide binding | adenyl ribonucleotide binding | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | malate dehydrogenase (decarboxylating) (NAD+) activity | malate dehydrogenase (decarboxylating) (NADP+) activity | metal ion binding | heterocyclic compound binding | oxidoreductase activity | small molecule binding

GO Biological Process

NADP biosynthetic process | oxidoreductase activity, acting on CH-OH group of donors | response to hormone | nicotinamide nucleotide biosynthetic process | malic enzyme activity | generation of precursor metabolites and energy | cellular process | dicarboxylic acid metabolic process | nucleotide metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | response to stimulus | monocarboxylic acid metabolic process | malate metabolic process | cellular nitrogen compound biosynthetic process | electron transport chain | cellular nitrogen compound metabolic process | cofactor metabolic process | cellular component assembly | cellular biosynthetic process | nucleotide biosynthetic process | malate dehydrogenase activity | nitrogen compound metabolic process | coenzyme biosynthetic process | phosphorus metabolic process | protein complex oligomerization | electron transfer activity | organophosphate metabolic process | cofactor biosynthetic process | regulation of nitrogen compound metabolic process | small molecule metabolic process | nucleobase-containing small molecule metabolic process | biosynthetic process | pyruvate metabolic process | aromatic compound biosynthetic process | carbohydrate metabolic process | protein tetramerization | phosphate-containing compound metabolic process | regulation of cellular metabolic process | carboxylic acid metabolic process | pyridine nucleotide biosynthetic process | protein-containing complex assembly | response to organic substance | metabolic process | oxidation-reduction process | nucleobase-containing compound metabolic process | organic substance metabolic process | regulation of phosphate metabolic process | organic acid metabolic process | NADP metabolic process | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | malate dehydrogenase (decarboxylating) (NAD+) activity | nicotinamide nucleotide metabolic process | malate dehydrogenase (decarboxylating) (NADP+) activity | heterocycle metabolic process | regulation of lipid metabolic process | cellular metabolic process | response to carbohydrate | oxidoreductase activity | regulation of NADP metabolic process | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | mitochondrion | membrane-bounded organelle | organelle | cytosol | intracellular