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QuickView for MEF2;jsessionid=A01E3C1909B4452B633F8EC7E8E36577;jsessionid=44CFA76EFB3F1944AE0DD3873AEC8F4E (gene)


Gene Symbol:
MEF2A Homo sapiens Homo sapiens
Full name:
myocyte enhancer factor 2A
Synonyms:
ADCAD1, RSRFC4, RSRFC9, mef2, myocyte-specific enhancer factor 2A, MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A), serum response factor-like protein 1
Genomic Location:
Chr 15: 97956185-98071524
Description:
The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and ap...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Danio rerio Gallus gallus Bos taurus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 15
15q26.3





GO Molecular Function

sequence-specific DNA binding | kinase binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | protein kinase binding | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | chromatin binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | protein heterodimerization activity | organic cyclic compound binding | transcription coactivator activity | transcription regulatory region sequence-specific DNA binding | protein binding | histone acetyltransferase binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II transcription factor binding | activating transcription factor binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | histone deacetylase binding | transcription coregulator activity | SMAD binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | cell morphogenesis | regulation of muscle system process | positive regulation of macromolecule biosynthetic process | actin filament-based process | neuron projection morphogenesis | muscle tissue development | intracellular signal transduction | regulation of localization | actin cytoskeleton organization | ERK5 cascade | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | response to metal ion | cell differentiation | striated muscle cell development | nervous system development | cell part morphogenesis | neurogenesis | generation of neurons | cardiac cell development | positive regulation of cellular biosynthetic process | cellular process | regulation of glucose import | localization | cell projection morphogenesis | neuron development | negative regulation of nucleic acid-templated transcription | positive regulation of nitrogen compound metabolic process | response to inorganic substance | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | positive regulation of cardiac muscle hypertrophy | positive regulation of muscle cell differentiation | muscle structure development | muscle cell differentiation | regulation of cellular process | regulation of metabolic process | organelle localization | ventricular cardiac muscle cell development | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | MAPK cascade | cellular response to metal ion | response to stimulus | muscle cell development | cell morphogenesis involved in neuron differentiation | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding | signal transduction by protein phosphorylation | cellular nitrogen compound biosynthetic process | regulation of blood circulation | cardiac muscle tissue development | positive regulation of glucose import | programmed cell death | supramolecular fiber organization | cellular response to inorganic substance | cellular localization | cellular nitrogen compound metabolic process | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | protein modification process | cellular biosynthetic process | mitochondrion organization | macromolecule modification | regulation of nucleic acid-templated transcription | apoptotic process | organelle assembly | ventricular cardiac myofibril assembly | system development | nitrogen compound metabolic process | multicellular organism development | phosphorus metabolic process | regulation of gene expression | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | cardiocyte differentiation | regulation of transcription by RNA polymerase II | positive regulation of cell differentiation | mitochondrion localization | positive regulation of glucose transmembrane transport | biosynthetic process | cardiac myofibril assembly | aromatic compound biosynthetic process | cardiac muscle cell development | phosphorylation | actomyosin structure organization | regulation of heart contraction | protein phosphorylation | cell morphogenesis involved in differentiation | phosphate-containing compound metabolic process | striated muscle tissue development | cell communication | regulation of cellular metabolic process | mitochondrial genome maintenance | heart development | transcription coactivator activity | regulation of RNA metabolic process | positive regulation of transport | striated muscle cell differentiation | neuron differentiation | mitochondrion distribution | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | regulation of cardiac muscle hypertrophy | DNA-binding transcription factor activity | cellular response to calcium ion | anatomical structure development | cell projection organization | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | neuron projection development | organic substance metabolic process | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | regulation of glucose transmembrane transport | animal organ development | gene expression | myofibril assembly | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | cytoskeleton organization | transcription, DNA-templated | dendrite morphogenesis | anatomical structure formation involved in morphogenesis | cardiac muscle cell differentiation | signaling | regulation of transcription, DNA-templated | cell development | cellular protein metabolic process | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | dendrite development | regulation of developmental process | developmental process | organelle organization | regulation of muscle cell differentiation | cellular protein modification process | negative regulation of transcription by RNA polymerase II | regulation of transport | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | ventricular cardiac muscle cell differentiation | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | response to calcium ion | positive regulation of metabolic process | cellular metabolic process | circulatory system development | muscle organ development | signal transduction | cardiac conduction | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | transcription factor complex | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | chromatin | nuclear chromosome | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | cytosol | intracellular