QuickView for MTHFR;jsessionid=1F655A875013ED8613E73E8091FD15D7;jsessionid=4905596BDB5194BFAA0D3F9D05D933AA (gene)
- Gene Symbol:
- Mthfr
Rattus norvegicus - Full name:
- methylenetetrahydrofolate reductase
- Synonyms:
- methylenetetrahydrofolate reductase, 5,10-methylenetetrahydrofolate reductase (NADPH), methylenetetrahydrofolate reductase (NAD(P)H)
- Genomic Location:
- Chr 5: 165110881-165126885
- Description:
-
converts 5,10 methylenetetrahydrofolate to 5-methyltetrahydrofolate; mutations in human may be associated with hyperhomocysteinaemia, and a risk factor for spina bifida in women
- Orthologs:
- Homo sapiens , Mus musculus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
NADP binding | cofactor binding | modified amino acid binding | methylenetetrahydrofolate reductase (NAD(P)H) activity | oxidoreductase activity, acting on the CH-NH group of donors | protein-containing complex binding | nucleotide binding | flavin adenine dinucleotide binding | coenzyme binding | catalytic activity | anion binding | ion binding | organic cyclic compound binding | FAD binding | heterocyclic compound binding | oxidoreductase activity | small molecule binding
GO Biological Process
response to extracellular stimulus | response to vitamin B2 | response to nutrient levels | response to cytokine | response to interleukin-1 | sulfur compound metabolic process | morphogenesis of an epithelium | nervous system development | response to drug | regulation of organelle organization | tetrahydrofolate metabolic process | methylenetetrahydrofolate reductase (NAD(P)H) activity | response to folic acid | cellular process | oxidoreductase activity, acting on the CH-NH group of donors | epithelial tube morphogenesis | chromatin organization | regulation of histone modification | response to hypoxia | sulfur amino acid biosynthetic process | tissue development | S-adenosylmethionine metabolic process | cellular amino acid metabolic process | regulation of cellular process | regulation of metabolic process | one-carbon metabolic process | organic cyclic compound metabolic process | epithelium development | cellular aromatic compound metabolic process | cellular component organization | folic acid-containing compound metabolic process | regulation of histone methylation | response to stimulus | embryonic epithelial tube formation | response to stress | cellular amino acid biosynthetic process | tube morphogenesis | chromatin maintenance | epithelial tube formation | cellular nitrogen compound metabolic process | cofactor metabolic process | cellular biosynthetic process | pteridine-containing compound metabolic process | embryo development | response to nitrogen compound | sulfur amino acid metabolic process | heterochromatin organization | system development | response to oxygen levels | nitrogen compound metabolic process | multicellular organism development | response to amino acid | neural tube closure | regulation of nitrogen compound metabolic process | small molecule metabolic process | methionine metabolic process | neural tube formation | cellular amide metabolic process | response to nutrient | biosynthetic process | neural tube development | regulation of cellular protein metabolic process | chordate embryonic development | regulation of cellular metabolic process | regulation of protein metabolic process | embryo development ending in birth or egg hatching | embryonic morphogenesis | drug metabolic process | carboxylic acid metabolic process | heterochromatin maintenance | response to organic substance | tissue morphogenesis | anatomical structure development | methionine biosynthetic process | cellular component maintenance | metabolic process | oxidation-reduction process | morphogenesis of embryonic epithelium | organic substance metabolic process | response to vitamin | tetrahydrofolate interconversion | regulation of chromosome organization | anatomical structure formation involved in morphogenesis | homocysteine metabolic process | response to organic cyclic compound | organic acid metabolic process | anatomical structure morphogenesis | developmental process | organelle organization | tube development | response to organonitrogen compound | tube closure | cellular modified amino acid metabolic process | heterocycle metabolic process | tube formation | chromosome organization | cellular metabolic process | oxidoreductase activity | regulation of cellular component organization | multicellular organismal process | regulation of chromatin organization
GO Cellular Component
synapse | cell | cytoplasm | cytosol | intracellular
