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QuickView for Mfn2;jsessionid=752A96ED3F94B6F36106787986108EDE;jsessionid=C880B083BB0298B16479FA415C5F91F5 (gene)


Gene Symbol:
Mfn2 Rattus norvegicus Rattus norvegicus
Full name:
mitofusin 2
Synonyms:
HSG, mitofusin-2, hypertension-related protein, mitochondrial transmembrane GTPase FZO1A, transmembrane GTPase MFN2
Genomic Location:
Chr 5: 164950988-164981895
Orthologs:
Homo sapiens Mus musculus D. melanogaster C. elegans Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:





GO Molecular Function

guanyl ribonucleotide binding | proteoglycan binding | GTPase binding | ribonucleoside binding | enzyme binding | ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | pyrophosphatase activity | Ras GTPase binding | catalytic activity | ubiquitin-like protein ligase binding | anion binding | nucleoside-triphosphatase activity | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | GTPase activity | purine nucleoside binding | purine ribonucleoside triphosphate binding | protein binding | protein homodimerization activity | ubiquitin protein ligase binding | protein dimerization activity | GTP binding | hydrolase activity, acting on acid anhydrides | small GTPase binding | nucleoside binding | purine ribonucleotide binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | guanyl nucleotide binding | small molecule binding

GO Biological Process

positive regulation of smooth muscle cell proliferation | response to extracellular stimulus | regulation of supramolecular fiber organization | response to radiation | cellular response to decreased oxygen levels | blastocyst formation | response to nutrient levels | cellular response to glucose stimulus | positive regulation of cellular component organization | regulation of cell morphogenesis | regulation of neurogenesis | developmental process involved in reproduction | positive regulation of ovarian follicle development | positive regulation of apoptotic process | regulation of cell development | protein localization to mitochondrion | regulation of localization | organelle fusion | macroautophagy | gonad development | regulation of programmed cell death | regulation of mitochondrial fission | eye development | negative regulation of glial cell proliferation | establishment of localization | regulation of autophagy | response to hormone | negative regulation of neuron death | negative regulation of cellular process | membrane fusion | positive regulation of developmental process | response to dexamethasone | response to metal ion | regulation of cardiac muscle cell apoptotic process | cell differentiation | male gamete generation | response to hypobaric hypoxia | nervous system development | cellular response to extracellular stimulus | negative regulation of mitochondrion organization | response to drug | cellular chemical homeostasis | cell part morphogenesis | positive regulation of gonad development | neurogenesis | glucose homeostasis | regulation of organelle organization | response to L-arginine | generation of neurons | membrane organization | intracellular transport | regulation of lipid transport | positive regulation of dendritic spine morphogenesis | positive regulation of vascular smooth muscle cell proliferation | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | negative regulation of gliogenesis | regulation of glucose import | regulation of dendritic spine morphogenesis | localization | cellular homeostasis | protein transport | mitochondrial fusion | regulation of mitochondrial membrane potential | negative regulation of signaling | positive regulation of reactive oxygen species metabolic process | reproductive system development | parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization | positive regulation of membrane potential | establishment of protein localization to mitochondrion | multicellular organismal reproductive process | regulation of estradiol secretion | macromolecule localization | negative regulation of apoptotic process | response to hypoxia | regulation of cell cycle | negative regulation of release of cytochrome c from mitochondria | regulation of neuron projection development | positive regulation of muscle cell apoptotic process | response to inorganic substance | establishment of localization in cell | negative regulation of cellular metabolic process | regulation of binding | regulation of cell differentiation | gamete generation | cellular response to low-density lipoprotein particle stimulus | negative regulation of apoptotic signaling pathway | regulation of cellular process | regulation of apoptotic process | positive regulation of insulin receptor signaling pathway | cellular response to lipid | regulation of metabolic process | catabolic process | organelle localization | cellular response to organonitrogen compound | response to topologically incorrect protein | cellular component organization | calcium ion homeostasis | cellular response to metal ion | cellular response to mercaptoethanol | development of primary sexual characteristics | positive regulation of autophagy of mitochondrion | positive regulation of dendrite morphogenesis | mitochondrion morphogenesis | response to stimulus | regulation of sarcomere organization | negative regulation of striated muscle cell differentiation | positive regulation of smooth muscle cell apoptotic process | cellular response to xenobiotic stimulus | cellular response to hypoxia | response to stress | intracellular protein transport | regulation of response to drug | regulation of cell proliferation | positive regulation of glucose import | response to glucose | programmed cell death | response to L-glutamate | reproduction | cellular response to inorganic substance | cellular localization | response to alcohol | positive regulation of mitophagy in response to mitochondrial depolarization | positive regulation of hormone secretion | regulation of macroautophagy | cellular response to organic cyclic compound | negative regulation of metabolic process | regulation of cellular component size | cellular component assembly | regulation of ovarian follicle development | regulation of synapse structure or activity | embryo development | negative regulation of reactive oxygen species biosynthetic process | mitochondrion organization | positive regulation of hydrogen peroxide biosynthetic process | regulation of chromatin binding | metal ion homeostasis | positive regulation of mitochondrion organization | regulation of membrane potential | response to nitrogen compound | apoptotic process | organelle assembly | cellular response to hormone stimulus | positive regulation of reactive oxygen species biosynthetic process | system development | cellular response to nutrient levels | response to oxygen levels | reproductive process | regulation of signal transduction | positive regulation of organelle organization | response to flavonoid | autophagosome organization | positive regulation of neuron projection development | regulation of actin cytoskeleton organization | multicellular organism development | response to activity | cellular glucose homeostasis | response to amino acid | negative regulation of striated muscle cell apoptotic process | response to fatty acid | regulation of actomyosin structure organization | regulation of hormone levels | regulation of hormone secretion | regulation of small GTPase mediated signal transduction | regulation of neuron differentiation | regulation of gene expression | regulation of female gonad development | positive regulation of secretion | organic substance transport | response to ketone | cellular response to stress | response to lipid | cell cycle | cellular response to testosterone stimulus | positive regulation of cellular metabolic process | cellular ion homeostasis | response to axon injury | cellular response to radiation | animal organ morphogenesis | positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization | negative regulation of smooth muscle cell proliferation | response to manganese ion | mitochondrial transport | cellular response to oxygen levels | regulation of synapse organization | positive regulation of cell projection organization | peptide transport | response to corticosteroid | response to nutrient | regulation of smooth muscle cell apoptotic process | protein localization to organelle | positive regulation of cell differentiation | mitochondrion localization | negative regulation of cardiac muscle cell apoptotic process | positive regulation of glucose transmembrane transport | positive regulation of cellular respiration | response to cadmium ion | mitochondrial calcium ion homeostasis | cellular response to glucocorticoid stimulus | regulation of hydrogen peroxide metabolic process | positive regulation of lipid localization | regulation of apoptotic signaling pathway | positive regulation of dendritic spine development | response to xenobiotic stimulus | cellular response to amino acid stimulus | cation homeostasis | cellular response to corticosteroid stimulus | sensory organ development | vacuole organization | positive regulation of cellular response to insulin stimulus | autophagy | negative regulation of sarcomere organization | cellular response to drug | regulation of mitochondrion organization | mitochondrial membrane organization | regulation of muscle cell apoptotic process | chordate embryonic development | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | eye morphogenesis | response to testosterone | positive regulation of response to drug | regulation of glial cell proliferation | regulation of endocrine process | positive regulation of signal transduction | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | response to monosaccharide | response to D-galactose | embryo development ending in birth or egg hatching | negative regulation of vascular smooth muscle cell proliferation | positive regulation of transport | positive regulation of chromatin binding | cellular response to lipoprotein particle stimulus | positive regulation of female gonad development | positive regulation of dendrite development | regulation of mitotic cell cycle | regulation of autophagy of mitochondrion | positive regulation of molecular function | multicellular organism reproduction | regulation of progesterone secretion | positive regulation of estradiol secretion | mitochondrion distribution | development of primary male sexual characteristics | regulation of cell morphogenesis involved in differentiation | cellular response to nutrient | response to organic substance | autophagosome assembly | cell cycle arrest | regulation of cellular respiration | male sex differentiation | response to wounding | response to antineoplastic agent | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | establishment of protein localization to organelle | anatomical structure development | regulation of dendrite morphogenesis | mitotic cell cycle | positive regulation of neurogenesis | metabolic process | positive regulation of cell development | negative regulation of programmed cell death | male gonad development | negative regulation of cytoskeleton organization | negative regulation of cell size | negative regulation of mitotic cell cycle | cellular protein localization | cellular response to carbohydrate stimulus | amide transport | negative regulation of muscle cell apoptotic process | chemical homeostasis | regulation of secretion | positive regulation of cell death | positive regulation of progesterone secretion | cell death | negative regulation of biosynthetic process | regulation of glucose transmembrane transport | animal organ development | regulation of insulin receptor signaling pathway | negative regulation of small GTPase mediated signal transduction | intracellular distribution of mitochondria | negative regulation of Ras protein signal transduction | positive regulation of programmed cell death | ion homeostasis | regulation of cellular response to insulin stimulus | cellular response to ionizing radiation | regulation of striated muscle cell differentiation | cellular response to steroid hormone stimulus | positive regulation of binding | positive regulation of autophagy | establishment of protein localization | blastocyst development | positive regulation of macroautophagy | regulation of postsynapse organization | cellular response to dexamethasone stimulus | protein localization to phagophore assembly site | camera-type eye development | regulation of reactive oxygen species biosynthetic process | anatomical structure formation involved in morphogenesis | negative regulation of cell cycle | regulation of dendrite development | regulation of cell communication | regulation of gliogenesis | response to mitochondrial depolarisation | negative regulation of signal transduction | regulation of dendritic spine development | mitotic cell cycle arrest | response to organic cyclic compound | protein localization | regulation of cell size | response to unfolded protein | regulation of Ras protein signal transduction | anatomical structure morphogenesis | cellular macromolecule localization | camera-type eye morphogenesis | reproductive structure development | regulation of nervous system development | regulation of developmental process | protein targeting to mitochondrion | developmental process | organelle organization | regulation of muscle cell differentiation | positive regulation of mitophagy | spermatogenesis | cellular response to manganese ion | regulation of transport | regulation of reactive oxygen species metabolic process | negative regulation of mitochondrial fission | negative regulation of cell proliferation | response to organonitrogen compound | cellular metal ion homeostasis | positive regulation of vascular associated smooth muscle cell apoptotic process | negative regulation of supramolecular fiber organization | response to electrical stimulus | response to calcium ion | negative regulation of muscle cell differentiation | regulation of generation of precursor metabolites and energy | in utero embryonic development | positive regulation of metabolic process | regulation of actin filament-based process | positive regulation of neuron differentiation | protein targeting | regulation of cell projection organization | positive regulation of lipid transport | cellular metabolic process | cellular response to organic substance | regulation of cell death | sex differentiation | regulation of smooth muscle cell proliferation | response to carbohydrate | response to steroid hormone | regulation of organelle assembly | positive regulation of cell morphogenesis involved in differentiation | negative regulation of cell death | negative regulation of cell development | carbohydrate homeostasis | divalent inorganic cation homeostasis | sexual reproduction | cellular response to oxygen-glucose deprivation | positive regulation of mitochondrial membrane potential | cellular response to L-glutamate | negative regulation of cell differentiation | regulation of cellular component organization | response to ionizing radiation | regulation of cytoskeleton organization | negative regulation of reactive oxygen species metabolic process | positive regulation of signaling | regulation of signaling | response to muscle activity | positive regulation of gene expression | response to glucocorticoid | negative regulation of neurogenesis | multicellular organismal process

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | organelle membrane | cell | organelle outer membrane | intrinsic component of membrane | cytoplasm | intracellular organelle | microtubule cytoskeleton | mitochondrion | intrinsic component of mitochondrial outer membrane | membrane-bounded organelle | organelle | mitochondrial outer membrane | mitochondrial envelope | outer membrane | mitochondrial membrane | cytosol | cytoskeleton | intracellular | membrane