QuickView for NPM1;jsessionid=5FEB095DA4D3B1721DF0375D093523E1;jsessionid=E72D346144EA4B722AEDD04BA465BDE4 (gene)
- Gene Symbol:
- Npm1
Mus musculus - Full name:
- nucleophosmin 1
- Synonyms:
- B23, NO38, Npm, nucleophosmin, nucleolar phosphoprotein B23, nucleolar protein NO38, numatrin
- Genomic Location:
- Chr 11: 33052511-33063056
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
ribosomal small subunit binding | kinase binding | protein kinase regulator activity | NF-kappaB binding | transcription regulatory region DNA binding | core promoter binding | kinase regulator activity | protein kinase inhibitor activity | protein kinase binding | protein kinase B binding | enzyme binding | nucleic acid binding | protein-containing complex binding | ribonucleotide binding | lipid binding | nucleotide binding | enzyme inhibitor activity | carbohydrate derivative binding | unfolded protein binding | phospholipid binding | molecular function regulator | chromatin binding | ribonucleoprotein complex binding | ATP binding | protein N-terminus binding | anion binding | adenyl nucleotide binding | p53 binding | DNA binding | purine nucleotide binding | identical protein binding | protein heterodimerization activity | ion binding | phosphatidylinositol-3,4,5-trisphosphate binding | organic cyclic compound binding | transcription coactivator activity | purine ribonucleoside triphosphate binding | protein binding | protein homodimerization activity | transcription factor binding | kinase inhibitor activity | activating transcription factor binding | protein dimerization activity | phosphatidylinositol binding | histone binding | ribosomal large subunit binding | purine ribonucleotide binding | enzyme regulator activity | adenyl ribonucleotide binding | drug binding | transcription coregulator activity | heterocyclic compound binding | rRNA binding | Tat protein binding | small molecule binding | phosphatidylinositol phosphate binding | RNA binding
GO Biological Process
RNA metabolic process | negative regulation of phosphorylation | protein homooligomerization | response to radiation | regulation of cell cycle process | regulation of endoribonuclease activity | positive regulation of macromolecule biosynthetic process | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | RNA processing | positive regulation of cellular component organization | ncRNA export from nucleus | regulation of cellular localization | nuclear export | protein stabilization | regulation of localization | protein kinase regulator activity | positive regulation of DNA-binding transcription factor activity | nucleosome organization | regulation of programmed cell death | establishment of localization | negative regulation of neuron death | negative regulation of cellular process | negative regulation of kinase activity | microtubule cytoskeleton organization | regulation of cardiac muscle cell apoptotic process | negative regulation of protein phosphorylation | positive regulation of phosphate metabolic process | regulation of DNA replication | regulation of organelle organization | rRNA export from nucleus | intracellular transport | microtubule-based process | regulation of mRNA processing | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | regulation of centriole replication | establishment of organelle localization | localization | cellular homeostasis | maturation of 5.8S rRNA | chromatin organization | regulation of DNA damage response, signal transduction by p53 class mediator | protein transport | kinase regulator activity | regulation of protein localization to nucleolus | protein kinase inhibitor activity | positive regulation of protein kinase activity | macromolecule localization | negative regulation of apoptotic process | microtubule organizing center organization | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | ribosome biogenesis | establishment of localization in cell | negative regulation of cellular metabolic process | ribosomal large subunit biogenesis | regulation of mRNA stability | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | organelle localization | regulation of mRNA splicing, via spliceosome | negative regulation of centrosome duplication | positive regulation of cell cycle phase transition | regulation of endodeoxyribonuclease activity | organic cyclic compound metabolic process | positive regulation of translation | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | protein export from nucleus | response to UV | regulation of translational initiation | response to stimulus | enzyme inhibitor activity | regulation of cellular protein localization | rRNA transport | regulation of centrosome cycle | positive regulation of protein metabolic process | cellular response to light stimulus | response to stress | intracellular protein transport | endonucleolytic cleavage involved in rRNA processing | negative regulation of protein kinase activity | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | posttranscriptional regulation of gene expression | regulation of cell proliferation | regulation of protein ubiquitination | regulation of cell cycle phase transition | ncRNA processing | protein destabilization | protein-DNA complex assembly | cellular localization | cellular nitrogen compound metabolic process | ribosomal small subunit export from nucleus | nucleic acid phosphodiester bond hydrolysis | cellular response to organic cyclic compound | negative regulation of metabolic process | regulation of cellular component size | positive regulation of RNA biosynthetic process | cellular component assembly | cellular biosynthetic process | ribosome localization | molecular function regulator | DNA repair | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | response to nitrogen compound | negative regulation of neuron apoptotic process | regulation of cell cycle G2/M phase transition | response to light stimulus | cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | regulation of protein stability | negative regulation of phosphate metabolic process | negative regulation of catalytic activity | negative regulation of protein kinase activity by regulation of protein phosphorylation | positive regulation of DNA replication | ribonucleoprotein complex localization | negative regulation of striated muscle cell apoptotic process | response to dsRNA | cellular response to DNA damage stimulus | protein complex oligomerization | regulation of catalytic activity | regulation of phosphorylation | ncRNA transcription | positive regulation of cell cycle | positive regulation of DNA-directed DNA polymerase activity | regulation of gene expression | organic substance transport | positive regulation of centrosome duplication | cellular response to stress | cell cycle | regulation of signal transduction by p53 class mediator | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular response to radiation | regulation of protein localization to nucleus | regulation of mRNA stability involved in cellular response to UV | regulation of nitrogen compound metabolic process | peptide transport | ribosomal subunit export from nucleus | regulation of RNA stability | regulation of transcription by RNA polymerase II | positive regulation of cell cycle G2/M phase transition | rRNA transcription | cleavage involved in rRNA processing | negative regulation of RNA splicing | negative regulation of cardiac muscle cell apoptotic process | positive regulation of protein localization to nucleus | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | RNA export from nucleus | cellular protein-containing complex assembly | establishment of RNA localization | negative regulation of mRNA processing | rRNA metabolic process | regulation of DNA-dependent DNA replication | cellular response to UV | regulation of muscle cell apoptotic process | regulation of cellular metabolic process | chromatin remodeling | regulation of protein kinase activity | regulation of neuron apoptotic process | positive regulation of DNA biosynthetic process | protein-containing complex localization | positive regulation of cytoskeleton organization | regulation of protein metabolic process | cellular response to dsRNA | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | transcription coactivator activity | regulation of RNA metabolic process | ribosomal large subunit export from nucleus | rRNA processing | cell aging | regulation of microtubule-based process | positive regulation of molecular function | regulation of centrosome duplication | protein-containing complex assembly | negative regulation of epithelial cell proliferation | positive regulation of protein modification process | regulation of growth | response to organic substance | endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | centrosome cycle | positive regulation of protein localization to nucleolus | kinase inhibitor activity | regulation of kinase activity | DNA metabolic process | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | chromatin assembly or disassembly | nucleobase-containing compound transport | metabolic process | regulation of RNA splicing | RNA phosphodiester bond hydrolysis, endonucleolytic | regulation of RNA biosynthetic process | negative regulation of programmed cell death | negative regulation of cytoskeleton organization | cellular protein localization | amide transport | negative regulation of muscle cell apoptotic process | regulation of response to DNA damage stimulus | nucleobase-containing compound metabolic process | organic substance metabolic process | nuclear transport | negative regulation of gene expression | maturation of LSU-rRNA | regulation of mRNA catabolic process | RNA phosphodiester bond hydrolysis | negative regulation of cellular protein metabolic process | gene expression | positive regulation of NF-kappaB transcription factor activity | positive regulation of kinase activity | regulation of phosphate metabolic process | DNA packaging | cytoskeleton organization | regulation of ribonuclease activity | establishment of protein localization | transcription, DNA-templated | RNA transport | chromatin assembly | negative regulation of cell cycle | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of molecular function | regulation of transcription, DNA-templated | response to organic cyclic compound | protein localization | regulation of epithelial cell proliferation | positive regulation of phosphorylation | regulation of cell size | enzyme regulator activity | cellular macromolecule localization | cellular macromolecule biosynthetic process | nucleocytoplasmic transport | maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | positive regulation of DNA metabolic process | developmental process | organelle organization | regulation of DNA biosynthetic process | positive regulation of cell cycle process | regulation of cell growth | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | ncRNA metabolic process | positive regulation of nucleic acid-templated transcription | DNA conformation change | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | ribosomal small subunit biogenesis | nucleosome assembly | positive regulation of metabolic process | chromosome organization | ribonucleoprotein complex biogenesis | cellular metabolic process | negative regulation of cell cycle process | cellular response to organic substance | regulation of protein localization | regulation of cell death | regulation of organelle assembly | regulation of translation | negative regulation of cell death | regulation of eIF2 alpha phosphorylation by dsRNA | aging | RNA localization | positive regulation of protein ubiquitination | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | negative regulation of mRNA splicing, via spliceosome | cell volume homeostasis | regulation of cytoskeleton organization | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | microtubule organizing center | cell | nuclear lumen | spindle pole centrosome | nucleolus | cytoplasm | spindle | intracellular organelle | ribosome | nuclear body | centrosome | protein-containing complex | protein-DNA complex | nucleoplasm | nuclear speck | ribonucleoprotein complex | microtubule cytoskeleton | granular component | small ribosomal subunit | spindle pole | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear matrix | large ribosomal subunit | cytosol | cytoskeleton | intracellular | nuclear periphery
