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QuickView for NR3C1;jsessionid=B7E85E03FC0E5B8DB1216B7C0FBD4348;jsessionid=51A3FCF60AB0D63EA5AEF45DEECCBD36 (gene)


Gene Symbol:
Nr3c1 Rattus norvegicus Rattus norvegicus
Full name:
nuclear receptor subfamily 3, group C, member 1
Synonyms:
GR, Gcr, Grl, glucocorticoid receptor
Genomic Location:
Chr 18: 32371500-32459145
Description:
glucocorticoid receptor that binds and activates hormone-dependent transcriptional enhancers
Orthologs:
Homo sapiens Mus musculus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
AACTTT_UNKNOWN ACCTGTTG_UNKNOWN GATA1_04 AHR_01 CEBP_01 CREB_Q2 CAGNYGKNAAA_UNKNOWN AHRARNT_01 LMO2COM_02 GATA1_05
miRNA binding sites
(Source: TargetScan):





GO Molecular Function

sequence-specific DNA binding | kinase binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | core promoter binding | nuclear receptor activity | cation binding | transcription factor activity, direct ligand regulated sequence-specific DNA binding | protein kinase binding | proximal promoter sequence-specific DNA binding | receptor tyrosine kinase binding | enzyme binding | nucleic acid binding | protein-containing complex binding | RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding | lipid binding | signaling receptor binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | steroid hormone receptor activity | chromatin binding | glucocorticoid receptor activity | steroid hormone binding | Hsp70 protein binding | RNA polymerase II regulatory region DNA binding | DNA binding | signaling receptor activity | sequence-specific double-stranded DNA binding | identical protein binding | protein heterodimerization activity | ubiquitin-like protein binding | ion binding | organic cyclic compound binding | protein tyrosine kinase binding | hormone binding | transcription coactivator activity | transcription regulatory region sequence-specific DNA binding | protein binding | protein homodimerization activity | zinc ion binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transition metal ion binding | SUMO binding | Hsp90 protein binding | steroid binding | heat shock protein binding | transcription coregulator activity | metal ion binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | brain development | positive regulation of striated muscle cell differentiation | response to radiation | regulation of muscle system process | positive regulation of macromolecule biosynthetic process | positive regulation of cellular component organization | regulation of neurogenesis | positive regulation of apoptotic process | regulation of cell development | regulation of localization | mammary gland duct morphogenesis | morphogenesis of an epithelium | positive regulation of striated muscle tissue development | regulation of carbohydrate metabolic process | regulation of programmed cell death | regulation of cardiac muscle cell differentiation | response to hormone | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | glucocorticoid mediated signaling pathway | positive regulation of developmental process | response to dexamethasone | negative regulation of RNA biosynthetic process | response to metal ion | regulation of heart growth | cell differentiation | respiratory tube development | nervous system development | response to drug | neurogenesis | generation of neurons | hormone-mediated signaling pathway | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | regulation of gene expression, epigenetic | nuclear receptor activity | response to magnesium ion | regulation of steroid hormone biosynthetic process | epithelial tube morphogenesis | chromatin organization | negative regulation of signaling | regulation of cell growth involved in cardiac muscle cell development | female pregnancy | transcription factor activity, direct ligand regulated sequence-specific DNA binding | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | regulation of striated muscle tissue development | response to corticosterone | response to growth factor | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | response to inorganic substance | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | regulation of cell differentiation | positive regulation of cardiac muscle hypertrophy | positive regulation of muscle cell differentiation | regulation of cellular process | positive regulation of cell growth | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding | organic cyclic compound metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | cellular component organization | response to transforming growth factor beta | cellular response to metal ion | mammary gland morphogenesis | head development | response to stimulus | maternal behavior | respiratory system development | cellular response to xenobiotic stimulus | gland morphogenesis | regulation of intracellular steroid hormone receptor signaling pathway | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | tube morphogenesis | response to peptide | circadian rhythm | reproduction | cellular response to inorganic substance | response to alcohol | androgen metabolic process | rhythmic process | cellular nitrogen compound metabolic process | cellular response to organic cyclic compound | blood circulation | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | steroid hormone receptor activity | steroid hormone mediated signaling pathway | modulation of chemical synaptic transmission | regulation of steroid biosynthetic process | cellular biosynthetic process | regulation of steroid metabolic process | glucocorticoid receptor activity | regulation of nucleic acid-templated transcription | response to nitrogen compound | cellular response to hormone stimulus | response to inactivity | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | positive regulation of neuron projection development | multicellular organism development | response to activity | mammary gland development | positive regulation of glutamate secretion | positive regulation of muscle organ development | lipid metabolic process | regulation of hormone levels | regulation of neuron differentiation | regulation of gene expression | positive regulation of secretion | response to ketone | response to lipid | positive regulation of cellular metabolic process | chromatin-mediated maintenance of transcription | animal organ morphogenesis | response to mercury ion | regulation of nitrogen compound metabolic process | positive regulation of cell projection organization | regulation of vascular permeability | response to corticosteroid | regulation of transcription by RNA polymerase II | positive regulation of gene expression, epigenetic | glucocorticoid receptor signaling pathway | positive regulation of cell differentiation | biosynthetic process | regulation of hormone metabolic process | aromatic compound biosynthetic process | cellular response to glucocorticoid stimulus | parental behavior | positive regulation of neuron death | regulation of glutamate secretion | positive regulation of cell growth involved in cardiac muscle cell development | positive regulation of dendritic spine development | response to xenobiotic stimulus | endocrine system development | cellular response to corticosteroid stimulus | cellular response to drug | cell communication | regulation of cellular metabolic process | chromatin remodeling | regulation of neuron apoptotic process | positive regulation of signal transduction | transcription coactivator activity | regulation of RNA metabolic process | positive regulation of transport | regulation of lipid biosynthetic process | negative regulation of glucocorticoid mediated signaling pathway | positive regulation of dendrite development | cellular response to transforming growth factor beta stimulus | multicellular organism reproduction | positive regulation of organ growth | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | regulation of glucocorticoid biosynthetic process | regulation of cardiac muscle hypertrophy | DNA-binding transcription factor activity | regulation of growth | response to organic substance | gland development | regulation of cardiac muscle tissue development | tissue morphogenesis | response to antineoplastic agent | positive regulation of neuron apoptotic process | response to insulin | anatomical structure development | negative regulation of synaptic plasticity | positive regulation of neurogenesis | regulation of glucose metabolic process | reproductive behavior | metabolic process | positive regulation of cell development | response to mineralocorticoid | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | positive regulation of glucocorticoid receptor signaling pathway | adrenal gland development | regulation of secretion | behavior | positive regulation of cell death | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | positive regulation of amino acid transport | animal organ development | positive regulation of ion transport | gene expression | muscle atrophy | positive regulation of programmed cell death | regulation of striated muscle cell differentiation | mammary gland epithelium development | regulation of glucocorticoid mediated signaling pathway | cellular response to steroid hormone stimulus | negative regulation of vascular permeability | positive regulation of organic acid transport | positive regulation of muscle tissue development | transcription, DNA-templated | lung development | cellular response to dexamethasone stimulus | intracellular receptor signaling pathway | regulation of dendrite development | positive regulation of cardiac muscle cell differentiation | steroid metabolic process | regulation of cell communication | negative regulation of signal transduction | response to arsenic-containing substance | positive regulation of developmental growth | regulation of dendritic spine development | signaling | positive regulation of growth | glucocorticoid metabolic process | regulation of transcription, DNA-templated | response to organic cyclic compound | positive regulation of intracellular steroid hormone receptor signaling pathway | regulation of developmental growth | hormone metabolic process | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of organ growth | regulation of nervous system development | regulation of developmental process | regulation of ion transport | developmental process | organelle organization | regulation of muscle cell differentiation | positive regulation of anion transport | regulation of cell growth | intracellular steroid hormone receptor signaling pathway | negative regulation of transcription by RNA polymerase II | tube development | regulation of transport | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of heart growth | response to organonitrogen compound | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | response to electrical stimulus | regulation of gluconeogenesis | regulation of anion transport | response to calcium ion | central nervous system development | regulation of lipid metabolic process | positive regulation of metabolic process | chromosome organization | regulation of synaptic plasticity | positive regulation of neuron differentiation | regulation of cell projection organization | cellular metabolic process | regulation of glucocorticoid metabolic process | cellular response to organic substance | regulation of cell death | positive regulation of cardiac muscle tissue development | response to steroid hormone | aging | regulation of cellular component organization | muscle system process | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | response to glucocorticoid | regulation of hormone biosynthetic process | cellular response to growth factor stimulus | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process | cellular response to magnesium ion

GO Cellular Component

dendritic spine | dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | somatodendritic compartment | microtubule organizing center | cell | nuclear lumen | cytoplasm | spindle | intracellular organelle | nuclear body | dendritic tree | protein-containing complex | cell projection | neuron spine | postsynapse | nucleoplasm | nuclear speck | postsynaptic density | microtubule cytoskeleton | asymmetric synapse | mitochondrion | membrane-bounded organelle | nucleus | organelle | postsynaptic specialization | membrane-enclosed lumen | cytosol | cytoskeleton | intracellular | membrane