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QuickView for Ndr2;jsessionid=B7AD436D5F31AD7BB738D9DDDD47AD90;jsessionid=920E053629FE884996AEC15620F40CB7 (gene)


Gene Symbol:
Nodal Mus musculus Mus musculus
Full name:
nodal
Synonyms:
Tg.413d, nodal
Genomic Location:
Chr 10: 60881048-60887384
Description:
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature ...
Orthologs:
Homo sapiens Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:


Transcripts Names
NM_013611
Protein Names
Q8BH87
P43021



GO Molecular Function

transforming growth factor beta receptor binding | signaling receptor binding | cytokine receptor binding | receptor serine/threonine kinase binding | molecular function regulator | activin receptor binding | type I activin receptor binding | protein binding | receptor regulator activity | growth factor activity | receptor ligand activity | cytokine activity

GO Biological Process

regulation of activin receptor signaling pathway | regulation of ERK1 and ERK2 cascade | brain development | SMAD protein signal transduction | cell morphogenesis | positive regulation of macromolecule biosynthetic process | regulation of cysteine-type endopeptidase activity | blastocyst formation | cell motility | cranial skeletal system development | developmental process involved in reproduction | floor plate morphogenesis | positive regulation of apoptotic process | regulation of cell development | regulation of localization | morphogenesis of an epithelium | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | mesodermal cell fate specification | negative regulation of cellular process | positive regulation of developmental process | negative regulation of RNA biosynthetic process | cell differentiation | positive regulation of epithelial cell proliferation | respiratory tube development | maternal placenta development | nervous system development | determination of left/right asymmetry in lateral mesoderm | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | mesenchyme development | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | cell fate specification | regulation of trophoblast cell migration | regulation of cell motility | localization | epithelial tube morphogenesis | mesoderm morphogenesis | heart morphogenesis | negative regulation of signaling | left lung development | determination of left/right symmetry | reproductive system development | mesoderm development | regulation of embryonic development | female pregnancy | positive regulation of pathway-restricted SMAD protein phosphorylation | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | stem cell population maintenance | digestive tract morphogenesis | regulation of proteolysis | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | positive regulation of activin receptor signaling pathway | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | negative regulation of cell motility | regulation of angiogenesis | regulation of cellular process | parturition | regulation of apoptotic process | regulation of metabolic process | hepaticobiliary system development | positive regulation of cellular protein metabolic process | epithelium development | neural fold formation | cellular component organization | response to transforming growth factor beta | regulation of chorionic trophoblast cell proliferation | head development | regulation of vasculature development | response to stimulus | vasculature development | respiratory system development | embryonic epithelial tube formation | positive regulation of protein metabolic process | positive regulation of peptidase activity | determination of heart left/right asymmetry | mesoderm formation | regulation of SMAD protein signal transduction | regulation of intracellular steroid hormone receptor signaling pathway | regulation of cell proliferation | activin receptor signaling pathway | tube morphogenesis | positive regulation of cell-cell adhesion | positive regulation of cysteine-type endopeptidase activity | regulation of epithelial cell differentiation | epithelial tube formation | reproduction | positive regulation of vascular endothelial growth factor production | embryonic skeletal system development | cardiovascular system development | positive regulation of proteolysis | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | regulation of cell adhesion | embryo development | cell-cell signaling | molecular function regulator | embryonic placenta development | anterior/posterior pattern specification | regulation of nucleic acid-templated transcription | left lung morphogenesis | formation of anatomical boundary | locomotion | response to BMP | system development | reproductive process | regulation of signal transduction | axial mesoderm formation | multicellular organism development | cell migration | regulation of peptidase activity | regulation of MAPK cascade | regulation of catalytic activity | regulation of phosphorylation | trophectodermal cell differentiation | determination of bilateral symmetry | regulation of gene expression | embryonic heart tube morphogenesis | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | animal organ morphogenesis | liver development | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | lateral mesoderm development | regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of intracellular signal transduction | neural tube formation | regulation of cellular component movement | regulation of transcription by RNA polymerase II | morphogenesis of an epithelial fold | endoderm formation | positive regulation of hydrolase activity | axial mesoderm morphogenesis | negative regulation of intracellular steroid hormone receptor signaling pathway | neural tube development | regulation of cellular protein metabolic process | positive regulation of SMAD protein signal transduction | digestive tract development | positive regulation of endopeptidase activity | heart looping | cell morphogenesis involved in differentiation | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | mesodermal cell fate commitment | gastrulation with mouth forming second | proximal/distal pattern formation | regulation of timing of cell differentiation | chordate embryonic development | cell communication | regulation of cellular metabolic process | transmembrane receptor protein serine/threonine kinase signaling pathway | trophectodermal cellular morphogenesis | skeletal system morphogenesis | anterior/posterior axis specification | mesendoderm development | regulation of protein metabolic process | positive regulation of signal transduction | regulation of androgen receptor signaling pathway | heart development | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | embryonic morphogenesis | negative regulation of epithelial cell differentiation | positive regulation of molecular function | cellular response to transforming growth factor beta stimulus | nodal signaling pathway | specification of axis polarity | multicellular organism reproduction | embryonic organ morphogenesis | embryonic cranial skeleton morphogenesis | regulation of signaling receptor activity | maternal process involved in female pregnancy | maternal process involved in parturition | receptor regulator activity | regionalization | axis specification | positive regulation of protein modification process | response to organic substance | gland development | tissue morphogenesis | digestive system development | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | embryonic heart tube development | anatomical structure development | cell surface receptor signaling pathway | growth factor activity | embryonic skeletal system morphogenesis | cell fate commitment | inhibition of neuroepithelial cell differentiation | regulation of RNA biosynthetic process | primitive streak formation | negative regulation of transcription, DNA-templated | embryonic organ development | positive regulation of cell death | morphogenesis of embryonic epithelium | receptor ligand activity | cytokine activity | maintenance of cell number | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | proximal/distal axis specification | negative regulation of cellular component movement | positive regulation of ERK1 and ERK2 cascade | positive regulation of programmed cell death | epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification | regulation of phosphate metabolic process | blastocyst development | positive regulation of cytokine production | positive regulation of MAPK cascade | lung development | negative regulation of chorionic trophoblast cell proliferation | transforming growth factor beta receptor signaling pathway | anatomical structure formation involved in morphogenesis | negative regulation of androgen receptor signaling pathway | BMP signaling pathway | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | axial mesodermal cell fate specification | cell development | nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry | regulation of epithelial cell proliferation | positive regulation of phosphorylation | cell migration involved in gastrulation | endodermal cell differentiation | regulation of cytokine production | floor plate development | endoderm development | anatomical structure morphogenesis | regulation of endopeptidase activity | cell fate commitment involved in formation of primary germ layer | axial mesoderm development | reproductive structure development | regulation of developmental process | developmental process | negative regulation of transcription by RNA polymerase II | tube development | regulation of gastrulation | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | regulation of cell-cell adhesion | positive regulation of nucleic acid-templated transcription | regulation of development, heterochronic | lung morphogenesis | formation of primary germ layer | positive regulation of transcription by RNA polymerase II | embryonic process involved in female pregnancy | regulation of vascular endothelial growth factor production | tube formation | central nervous system development | mesodermal cell differentiation | in utero embryonic development | positive regulation of metabolic process | cellular response to BMP stimulus | skeletal system development | gastrulation | polarity specification of proximal/distal axis | placenta development | ameboidal-type cell migration | cellular response to organic substance | regulation of cell death | negative regulation of trophoblast cell migration | negative regulation of cell development | circulatory system development | negative regulation of locomotion | positive regulation of angiogenesis | negative regulation of cell differentiation | transforming growth factor beta receptor signaling pathway involved in primitive streak formation | positive regulation of signaling | signal transduction | regulation of signaling | regulation of pathway-restricted SMAD protein phosphorylation | positive regulation of gene expression | embryonic pattern specification | cellular response to growth factor stimulus | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

extracellular region | extracellular space