QuickView for OPRK1;jsessionid=4FB889DFB6B0B58404D9450348BFC83D;jsessionid=9A2D32D921D2D5C28153A0D82AA322F8 (gene)

Gene Symbol:

Oprk1 Rattus norvegicus

Full name:

opioid receptor, kappa 1

Synonyms:

kappa-type opioid receptor, K-OR-1, KOR-1

Genomic Location:

Chr 5: 14037660-14055460

Description:

This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays...

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This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.

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Orthologs:

Homo sapiens ,  Mus musculus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTTGAG_MIR373 ,  GGGCGGR_SP1_Q6

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