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QuickView for OPRM1;jsessionid=E371529C066C0F681E553FC164DF14DE;jsessionid=B7EEDCBDADCA1CFE035555FCC602BAB9 (gene)


Gene Symbol:
Oprm1 Mus musculus Mus musculus
Full name:
opioid receptor, mu 1
Synonyms:
M-OR-1, MOP-R, MOR-1, MOR-1O, Oprm, mor, muOR, mu-type opioid receptor, MOP receptor, mu opioid receptor MOR-1BI, mu opioid receptor MOR-1P, mu opioid receptor splice variant mMOR-1Z
Genomic Location:
Chr 10: 3308332-3557942
Description:
This gene encodes the mu opioid receptor which is where drugs such as morphine and other opioids have pharmacological effects. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Orthologs:
Homo sapiens Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):





GO Molecular Function

neurotransmitter receptor activity | peptide binding | voltage-gated ion channel activity | filamin binding | passive transmembrane transporter activity | transmembrane signaling receptor activity | neuropeptide binding | beta-endorphin receptor activity | transmembrane transporter activity | G-protein coupled receptor activity | ion gated channel activity | neuropeptide receptor activity | voltage-gated calcium channel activity | morphine receptor activity | protein domain specific binding | cytoskeletal protein binding | cation transmembrane transporter activity | amide binding | signaling receptor activity | transporter activity | calcium ion transmembrane transporter activity | ion transmembrane transporter activity | opioid receptor activity | protein binding | metal ion transmembrane transporter activity | voltage-gated cation channel activity | G-protein beta-subunit binding | cation channel activity | peptide receptor activity | inorganic cation transmembrane transporter activity | G-protein coupled peptide receptor activity | voltage-gated channel activity | channel activity | calcium channel activity | melanocortin receptor activity | ion channel activity | G-protein alpha-subunit binding | protein C-terminus binding | substrate-specific channel activity

GO Biological Process

response to extracellular stimulus | adenylate cyclase-inhibiting opioid receptor signaling pathway | negative regulation of G-protein coupled receptor protein signaling pathway | regulation of ERK1 and ERK2 cascade | response to nutrient levels | regulation of neurogenesis | negative regulation of peptide secretion | intracellular signal transduction | regulation of cell development | regulation of localization | response to isoquinoline alkaloid | establishment of localization | regulation of nitric oxide biosynthetic process | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | excitatory postsynaptic potential | nervous system development | response to drug | cellular chemical homeostasis | neurogenesis | positive regulation of phosphate metabolic process | negative regulation of protein secretion | voltage-gated ion channel activity | generation of neurons | response to antibiotic | positive regulation of cellular biosynthetic process | cellular process | neuropeptide signaling pathway | response to morphine | localization | cellular homeostasis | passive transmembrane transporter activity | negative regulation of signaling | metal ion transport | chemical synaptic transmission | positive regulation of reactive oxygen species metabolic process | negative regulation of secretion | positive regulation of nitrogen compound metabolic process | regulation of appetite | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | regulation of neurological system process | regulation of cell differentiation | beta-endorphin receptor activity | regulation of cellular process | regulation of metabolic process | regulation of cytosolic calcium ion concentration | transmembrane transporter activity | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | calcium ion homeostasis | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | G-protein coupled receptor activity | regulation of peptide secretion | negative regulation of lyase activity | response to stimulus | negative regulation of protein transport | ion gated channel activity | positive regulation of nitric oxide metabolic process | positive regulation of protein metabolic process | cellular response to xenobiotic stimulus | regulation of neurotransmitter receptor activity | divalent metal ion transport | response to alcohol | neuropeptide receptor activity | negative regulation of transport | cellular response to organic cyclic compound | regulation of protein transport | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | negative regulation of nitric oxide biosynthetic process | negative regulation of Wnt protein secretion | regulation of peptide transport | negative regulation of reactive oxygen species biosynthetic process | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | metal ion homeostasis | response to ethanol | regulation of membrane potential | voltage-gated calcium channel activity | regulation of cellular response to stress | regulation of neurotransmitter levels | response to nitrogen compound | positive regulation of reactive oxygen species biosynthetic process | morphine receptor activity | system development | regulation of signal transduction | negative regulation of secretion by cell | positive regulation of response to food | multicellular organism development | negative regulation of catalytic activity | calcium ion transmembrane transport | regulation of MAPK cascade | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | adenylate cyclase-activating G-protein coupled receptor signaling pathway | regulation of catalytic activity | regulation of phosphorylation | ion transmembrane transport | regulation of sensory perception of pain | cellular response to ammonium ion | opioid receptor signaling pathway | regulation of postsynaptic membrane potential | nervous system process | regulation of response to food | synaptic signaling | cation transmembrane transporter activity | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | behavioral response to ethanol | response to ammonium ion | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | cellular response to alkaloid | calcium ion transmembrane transporter activity | positive regulation of appetite | ion transmembrane transporter activity | positive regulation of cell differentiation | second-messenger-mediated signaling | locomotory behavior | sensory perception of pain | regulation of cellular protein metabolic process | eating behavior | negative regulation of adenylate cyclase activity | response to toxic substance | regulation of cyclase activity | response to xenobiotic stimulus | cation homeostasis | cellular response to drug | dopamine receptor signaling pathway | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | cyclic-nucleotide-mediated signaling | regulation of protein metabolic process | positive regulation of signal transduction | regulation of cAMP-mediated signaling | cellular calcium ion homeostasis | homeostatic process | regulation of protein phosphorylation | opioid receptor activity | cation transmembrane transport | regulation of signaling receptor activity | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | cAMP-mediated signaling | metal ion transmembrane transporter activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | positive regulation of neurogenesis | voltage-gated cation channel activity | positive regulation of cell development | negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway | cellular response to isoquinoline alkaloid | chemical homeostasis | calcium ion transport | regulation of secretion | behavior | negative regulation of biosynthetic process | regulation of protein secretion | positive regulation of ERK1 and ERK2 cascade | positive regulation of cAMP-mediated signaling | ion homeostasis | regulation of phosphate metabolic process | inorganic cation transmembrane transport | response to alkaloid | regulation of ion transmembrane transport | phospholipase C-activating G-protein coupled receptor signaling pathway | positive regulation of MAPK cascade | regulation of adenylate cyclase activity | regulation of reactive oxygen species biosynthetic process | cation channel activity | adult behavior | sensory perception | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | transmembrane transport | signaling | feeding behavior | inorganic cation transmembrane transporter activity | G-protein coupled peptide receptor activity | response to organic cyclic compound | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | positive regulation of phosphorylation | voltage-gated channel activity | cation transport | channel activity | regulation of NMDA receptor activity | regulation of nervous system development | negative regulation of cytosolic calcium ion concentration | regulation of developmental process | regulation of ion transport | regulation of G-protein coupled receptor protein signaling pathway | developmental process | calcium channel activity | negative regulation of cAMP-mediated signaling | melanocortin receptor activity | regulation of transport | regulation of reactive oxygen species metabolic process | regulation of cation channel activity | response to organonitrogen compound | cellular metal ion homeostasis | positive regulation of nitric oxide biosynthetic process | regulation of glutamate receptor signaling pathway | ion channel activity | response to anesthetic | cellular response to morphine | positive regulation of metabolic process | ion transport | adenylate cyclase-activating dopamine receptor signaling pathway | cellular response to organic substance | regulation of protein localization | divalent inorganic cation homeostasis | substrate-specific channel activity | negative regulation of reactive oxygen species metabolic process | positive regulation of signaling | signal transduction | regulation of signaling | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

integral component of membrane | dendrite | sarcolemma | neuron projection | somatodendritic compartment | adherens junction | cell projection membrane | focal adhesion | cytoplasmic vesicle | cell body | cell | neuronal cell body | intrinsic component of membrane | cytoplasm | dendrite cytoplasm | cell-substrate junction | intracellular organelle | membrane microdomain | dendritic tree | leading edge membrane | cell projection | endomembrane system | plasma membrane bounded cell projection cytoplasm | plasma membrane | perikaryon | cell leading edge | membrane raft | vesicle | cytoplasmic region | integral component of plasma membrane | endosome | dendrite membrane | membrane-bounded organelle | organelle | cell periphery | cell-substrate adherens junction | intracellular vesicle | intracellular | cell junction | membrane | neuron projection membrane | intrinsic component of plasma membrane