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QuickView for P2X2;jsessionid=FA7A3E4E9D73CE71F4050DB3A7A3E5B3;jsessionid=31B26E084BC1665AC6174572F4A9B829 (gene)


Gene Symbol:
P2RX2 Homo sapiens Homo sapiens
Full name:
purinergic receptor P2X 2
Synonyms:
DFNA41, P2X2, P2X purinoceptor 2, ATP receptor, P2X Receptor, subunit 2, purinergic receptor P2X, ligand gated ion channel, 2
Genomic Location:
Chr 12: 131705476-131709045
Description:
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Cytogenetic Map:
chr 12
12q24.33





GO Molecular Function

ATP-gated ion channel activity | passive transmembrane transporter activity | transmembrane signaling receptor activity | ribonucleotide binding | transmembrane transporter activity | ligand-gated ion channel activity | nucleotide binding | ion gated channel activity | carbohydrate derivative binding | ATP binding | anion binding | adenyl nucleotide binding | cation transmembrane transporter activity | signaling receptor activity | purine nucleotide binding | transporter activity | identical protein binding | ion transmembrane transporter activity | extracellular ligand-gated ion channel activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | excitatory extracellular ligand-gated ion channel activity | cation channel activity | inorganic cation transmembrane transporter activity | purine ribonucleotide binding | adenyl ribonucleotide binding | channel activity | drug binding | purinergic nucleotide receptor activity | ion channel activity | heterocyclic compound binding | extracellularly ATP-gated cation channel activity | substrate-specific channel activity | small molecule binding

GO Biological Process

response to extracellular stimulus | behavioral response to pain | protein homooligomerization | response to nutrient levels | response to ATP | detection of stimulus | regulation of cellular localization | muscle tissue development | regulation of localization | establishment of localization | cell differentiation | excitatory postsynaptic potential | purinergic nucleotide receptor signaling pathway | ATP-gated ion channel activity | striated muscle cell development | response to drug | cellular chemical homeostasis | sensory perception of mechanical stimulus | response to organophosphorus | cellular process | localization | cellular homeostasis | regulation of calcium-mediated signaling | passive transmembrane transporter activity | myotube cell development | chemical synaptic transmission | hemostasis | response to hypoxia | tissue development | muscle structure development | muscle cell differentiation | skeletal muscle organ development | regulation of cellular process | regulation of cytosolic calcium ion concentration | transmembrane transporter activity | neurological system process involved in regulation of systemic arterial blood pressure | ligand-gated ion channel activity | smooth muscle contraction | cellular component organization | calcium ion homeostasis | muscle contraction | response to stimulus | ion gated channel activity | muscle cell development | response to pain | response to stress | skeletal muscle tissue development | peristalsis | response to ischemia | blood circulation | cellular component assembly | cell-cell signaling | muscle fiber development | cell surface receptor signaling pathway involved in cell-cell signaling | metal ion homeostasis | urinary bladder smooth muscle contraction | blood coagulation | regulation of membrane potential | response to nitrogen compound | regulation of calcium ion transport into cytosol | system development | response to oxygen levels | regulation of signal transduction | detection of chemical stimulus | multicellular organism development | response to purine-containing compound | protein complex oligomerization | ion transmembrane transport | wound healing | regulation of postsynaptic membrane potential | nervous system process | regulation of blood pressure | synaptic signaling | cation transmembrane transporter activity | regulation of systemic arterial blood pressure | neuromuscular junction development | cellular ion homeostasis | positive regulation of cytosolic calcium ion concentration | positive regulation of intracellular signal transduction | response to nutrient | synapse organization | ion transmembrane transporter activity | positive regulation of calcium-mediated signaling | extracellular ligand-gated ion channel activity | cation homeostasis | striated muscle tissue development | cellular cation homeostasis | cell communication | sensory perception of sound | positive regulation of signal transduction | cellular calcium ion homeostasis | neuromuscular synaptic transmission | homeostatic process | positive regulation of transport | striated muscle cell differentiation | coagulation | cation transmembrane transport | protein-containing complex assembly | multicellular organismal response to stress | response to organic substance | response to wounding | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | regulation of body fluid levels | chemical homeostasis | behavior | animal organ development | positive regulation of ion transport | excitatory extracellular ligand-gated ion channel activity | ion homeostasis | detection of hypoxic conditions in blood by carotid body chemoreceptor signaling | cation channel activity | sensory perception | regulation of cell communication | transmembrane transport | signaling | inorganic cation transmembrane transporter activity | myotube differentiation | response to organic cyclic compound | cell development | sensory perception of chemical stimulus | cation transport | channel activity | positive regulation of calcium ion transport into cytosol | regulation of ion transport | developmental process | purinergic nucleotide receptor activity | regulation of calcium ion transport | sensory perception of taste | regulation of transport | response to organonitrogen compound | cellular metal ion homeostasis | ion channel activity | ion transport | response to carbohydrate | extracellularly ATP-gated cation channel activity | divalent inorganic cation homeostasis | substrate-specific channel activity | positive regulation of calcium ion transport | muscle organ development | muscle system process | positive regulation of signaling | signal transduction | regulation of signaling | skeletal muscle fiber development | multicellular organismal process

GO Cellular Component

integral component of organelle membrane | integral component of membrane | organelle inner membrane | intracellular membrane-bounded organelle | synapse | apical plasma membrane | somatodendritic compartment | organelle membrane | nuclear membrane | cell body | cell | neuronal cell body | nuclear inner membrane | intrinsic component of membrane | intracellular organelle | receptor complex | apical part of cell | protein-containing complex | endomembrane system | postsynapse | plasma membrane | nuclear envelope | integral component of plasma membrane | membrane-bounded organelle | nucleus | organelle | cell periphery | integral component of nuclear inner membrane | intracellular | membrane | intrinsic component of plasma membrane