QuickView for PARP;jsessionid=6E28165C66CE852F37B584E475E52F1E;jsessionid=0EF51A245270F89065D74805D88F9667 (gene)
- Gene Symbol:
- PARP1
Bos taurus - Full name:
- poly (ADP-ribose) polymerase 1
- Synonyms:
- ADPRT
- Genomic Location:
- Chr 16: 26391083-26432432
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
sequence-specific DNA binding | kinase binding | transcription regulatory region DNA binding | cofactor binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAD+ ADP-ribosyltransferase activity | cation binding | protein kinase binding | enzyme binding | nucleic acid binding | nucleotide binding | coenzyme binding | catalytic activity | protein ADP-ribosylase activity | protein N-terminus binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | identical protein binding | transferase activity, transferring glycosyl groups | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | zinc ion binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | NAD binding | transferase activity, transferring pentosyl groups | RNA polymerase II regulatory region sequence-specific DNA binding | transferase activity | transition metal ion binding | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | purine ribonucleotide metabolic process | double-strand break repair | response to radiation | regulation of muscle system process | positive regulation of macromolecule biosynthetic process | regulation of cellular localization | regulation of localization | peptidyl-amino acid modification | mitochondrial DNA metabolic process | response to hormone | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | regulation of DNA repair | positive regulation of cellular biosynthetic process | cellular process | nucleotide metabolic process | ribose phosphate metabolic process | nucleoside triphosphate metabolic process | positive regulation of nitrogen compound metabolic process | ribonucleotide metabolic process | peptidyl-serine ADP-ribosylation | negative regulation of cellular metabolic process | response to peptide hormone | positive regulation of cardiac muscle hypertrophy | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | cellular component organization | negative regulation of nucleotide metabolic process | positive regulation of response to DNA damage stimulus | response to UV | response to stimulus | purine nucleotide metabolic process | regulation of cellular protein localization | cellular response to light stimulus | response to stress | cellular nitrogen compound biosynthetic process | response to peptide | programmed cell death | cellular nitrogen compound metabolic process | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | cellular biosynthetic process | mitochondrion organization | macromolecule modification | DNA repair | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | response to nitrogen compound | protein ADP-ribosylase activity | apoptotic process | cellular response to hormone stimulus | response to light stimulus | nitrogen compound metabolic process | negative regulation of phosphate metabolic process | negative regulation of ATP metabolic process | cellular response to peptide hormone stimulus | phosphorus metabolic process | cellular response to DNA damage stimulus | cellular response to insulin stimulus | regulation of catalytic activity | cellular response to oxidative stress | regulation of gene expression | cellular response to stress | cellular response to peptide | organophosphate metabolic process | positive regulation of cellular metabolic process | cellular response to radiation | regulation of nitrogen compound metabolic process | ATP generation from poly-ADP-D-ribose | small molecule metabolic process | regulation of transcription by RNA polymerase II | response to oxidative stress | nucleobase-containing small molecule metabolic process | biosynthetic process | aromatic compound biosynthetic process | phosphate-containing compound metabolic process | cellular response to UV | regulation of cellular metabolic process | mitochondrial genome maintenance | regulation of RNA metabolic process | mitochondrial DNA repair | drug metabolic process | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | regulation of cardiac muscle hypertrophy | DNA-binding transcription factor activity | response to organic substance | protein poly-ADP-ribosylation | DNA metabolic process | response to insulin | protein ADP-ribosylation | metabolic process | regulation of RNA biosynthetic process | regulation of response to DNA damage stimulus | nucleobase-containing compound metabolic process | organic substance metabolic process | regulation of single strand break repair | cell death | negative regulation of biosynthetic process | gene expression | negative regulation of ATP biosynthetic process | regulation of ATP metabolic process | regulation of phosphate metabolic process | transcription, DNA-templated | regulation of transcription, DNA-templated | cellular protein metabolic process | cellular macromolecule biosynthetic process | positive regulation of DNA metabolic process | organelle organization | cellular protein modification process | carbohydrate derivative metabolic process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of single strand break repair | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | ATP metabolic process | cellular response to organic substance | regulation of protein localization | positive regulation of gene expression | positive regulation of DNA repair | macromolecule metabolic process | regulation of phosphorus metabolic process
GO Cellular Component
site of DNA damage | chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | transcription factor complex | nucleolus | cytoplasm | intracellular organelle | protein-containing complex | endomembrane system | protein-DNA complex | nuclear envelope | mitochondrion | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
