QuickView for PARP;jsessionid=867EAB49A8E9D52DCB0E3FC9120097FC;jsessionid=8C8F61D3ED8F245BB5072EAE4E932ED7 (gene)
- Gene Symbol:
- PARP1
Homo sapiens - Full name:
- poly(ADP-ribose) polymerase 1
- Synonyms:
- ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1, poly [ADP-ribose] polymerase 1, ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase), ADP-ribosyltransferase NAD(+), ADP-ribosyltransferase diphtheria toxin-like 1, NAD(+) ADP-ribosyltransferase 1, poly (ADP-ribose) polymerase family, member 1, poly(ADP-ribose) synthetase, poly(ADP-ribosyl)transferase, poly[ADP-ribose] synthase 1
- Genomic Location:
- Chr 1: 224615015-224662424
- Description:
-
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation o...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
1q42.12
GO Molecular Function
sequence-specific DNA binding | kinase binding | transcription regulatory region DNA binding | cofactor binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAD+ ADP-ribosyltransferase activity | cation binding | hormone receptor binding | protein kinase binding | enzyme binding | nucleic acid binding | nucleotide binding | estrogen receptor binding | coenzyme binding | signaling receptor binding | catalytic activity | protein ADP-ribosylase activity | protein N-terminus binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | identical protein binding | nuclear hormone receptor binding | transferase activity, transferring glycosyl groups | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | zinc ion binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | NAD binding | transferase activity, transferring pentosyl groups | RNA polymerase II regulatory region sequence-specific DNA binding | transferase activity | transition metal ion binding | steroid hormone receptor binding | histone deacetylase binding | SMAD binding | metal ion binding | heterocyclic compound binding | R-SMAD binding | small molecule binding | RNA binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | signal transduction involved in regulation of gene expression | purine ribonucleotide metabolic process | double-strand break repair | response to radiation | regulation of muscle system process | positive regulation of macromolecule biosynthetic process | telomere maintenance | detection of stimulus | cellular response to zinc ion | nucleotide-excision repair, DNA damage recognition | regulation of cellular response to oxidative stress | positive regulation of cellular component organization | regulation of response to oxidative stress | regulation of cellular localization | proteolysis | regulation of localization | regulation of programmed cell death | peptidyl-amino acid modification | mitochondrial DNA metabolic process | regulation of DNA methylation | response to hormone | myeloid cell differentiation | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | protein processing | negative regulation of RNA biosynthetic process | response to metal ion | cell differentiation | regulation of organelle organization | negative regulation of DNA metabolic process | regulation of DNA repair | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | regulation of mitochondrial membrane potential | nucleotide metabolic process | positive regulation of myofibroblast differentiation | immune system development | ribose phosphate metabolic process | negative regulation of nucleic acid-templated transcription | global genome nucleotide-excision repair | nucleoside triphosphate metabolic process | response to growth factor | positive regulation of nitrogen compound metabolic process | ribonucleotide metabolic process | peptidyl-serine ADP-ribosylation | response to inorganic substance | negative regulation of cellular metabolic process | response to peptide hormone | regulation of binding | regulation of cell differentiation | positive regulation of cardiac muscle hypertrophy | anatomical structure homeostasis | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | regulation of protein complex assembly | organic cyclic compound metabolic process | RNA biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | regulation of mitochondrial depolarization | cellular component organization | negative regulation of nucleotide metabolic process | positive regulation of response to DNA damage stimulus | response to transforming growth factor beta | cellular response to metal ion | response to UV | response to stimulus | purine nucleotide metabolic process | regulation of cellular protein localization | positive regulation of mitochondrial depolarization | regulation of SMAD protein complex assembly | cellular response to light stimulus | regulation of SMAD protein signal transduction | response to stress | regulation of intracellular steroid hormone receptor signaling pathway | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | response to peptide | programmed cell death | protein-DNA complex assembly | regulation of transcription regulatory region DNA binding | cellular response to inorganic substance | response to alcohol | macrophage differentiation | cellular nitrogen compound metabolic process | telomere organization | regulation of DNA binding | nucleic acid phosphodiester bond hydrolysis | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | cellular component assembly | protein modification process | cellular biosynthetic process | mitochondrion organization | DNA recombination | macromolecule modification | DNA repair | regulation of nucleic acid-templated transcription | regulation of membrane potential | leukocyte differentiation | regulation of cellular response to stress | response to nitrogen compound | protein ADP-ribosylase activity | apoptotic process | cellular response to hormone stimulus | response to light stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | double-strand break repair via homologous recombination | multicellular organism development | negative regulation of ATP metabolic process | cellular response to peptide hormone stimulus | phosphorus metabolic process | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | cellular response to DNA damage stimulus | regulation of telomere maintenance | cellular response to insulin stimulus | regulation of catalytic activity | regulation of intracellular estrogen receptor signaling pathway | cellular response to oxidative stress | nucleotide-excision repair, DNA incision, 5'-to lesion | regulation of intrinsic apoptotic signaling pathway | regulation of gene expression | response to ketone | cellular response to stress | response to lipid | cellular response to peptide | myeloid leukocyte differentiation | organophosphate metabolic process | regulation of membrane depolarization | positive regulation of cellular metabolic process | cellular response to radiation | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | ATP generation from poly-ADP-D-ribose | enzyme linked receptor protein signaling pathway | small molecule metabolic process | positive regulation of protein complex assembly | response to corticosteroid | regulation of transcription by RNA polymerase II | response to oxidative stress | positive regulation of cell differentiation | nucleobase-containing small molecule metabolic process | positive regulation of protein localization to nucleus | biosynthetic process | aromatic compound biosynthetic process | positive regulation of SMAD protein signal transduction | cellular protein-containing complex assembly | nucleotide-excision repair, preincision complex stabilization | positive regulation of neuron death | protein maturation | regulation of apoptotic signaling pathway | response to gamma radiation | phosphate-containing compound metabolic process | cellular response to UV | regulation of telomere maintenance via telomere lengthening | positive regulation of intracellular estrogen receptor signaling pathway | cell communication | regulation of cellular metabolic process | mitochondrial genome maintenance | transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of neuron apoptotic process | cellular response to amyloid-beta | positive regulation of signal transduction | response to aldosterone | homeostatic process | response to zinc ion | regulation of RNA metabolic process | negative regulation of telomere maintenance | mitochondrial DNA repair | regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | drug metabolic process | positive regulation of molecular function | cellular response to transforming growth factor beta stimulus | protein-containing complex assembly | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | regulation of cardiac muscle hypertrophy | DNA-binding transcription factor activity | response to organic substance | protein poly-ADP-ribosylation | DNA metabolic process | regulation of intracellular signal transduction | nucleotide-excision repair, DNA incision | response to insulin | anatomical structure development | protein ADP-ribosylation | cell surface receptor signaling pathway | DNA damage response, detection of DNA damage | metabolic process | nucleotide-excision repair | response to mineralocorticoid | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | chemical homeostasis | positive regulation of cell death | regulation of response to DNA damage stimulus | nucleobase-containing compound metabolic process | positive regulation of cellular component biogenesis | organic substance metabolic process | regulation of single strand break repair | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | ion homeostasis | negative regulation of ATP biosynthetic process | regulation of ATP metabolic process | regulation of phosphate metabolic process | regulation of chromosome organization | positive regulation of binding | transcription, DNA-templated | protein autoprocessing | transforming growth factor beta receptor signaling pathway | regulation of cell communication | negative regulation of chromosome organization | signaling | response to amyloid-beta | regulation of transcription, DNA-templated | response to organic cyclic compound | positive regulation of intracellular steroid hormone receptor signaling pathway | negative regulation of telomere maintenance via telomere lengthening | positive regulation of DNA binding | cellular protein metabolic process | cellular macromolecule biosynthetic process | regulation of developmental process | positive regulation of DNA metabolic process | recombinational repair | developmental process | organelle organization | cellular protein modification process | negative regulation of transcription by RNA polymerase II | carbohydrate derivative metabolic process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of single strand break repair | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | ATP metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | response to steroid hormone | regulation of cellular component organization | response to ionizing radiation | positive regulation of signaling | signal transduction | regulation of signaling | nucleotide-excision repair, preincision complex assembly | positive regulation of gene expression | positive regulation of transcription regulatory region DNA binding | positive regulation of DNA repair | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
site of DNA damage | chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | transcription factor complex | nucleolus | cytoplasm | intracellular organelle | protein-containing complex | endomembrane system | protein-DNA complex | nucleoplasm | nuclear envelope | nuclear chromosome | mitochondrion | chromosome, telomeric region | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromosome, telomeric region | intracellular | membrane
