QuickView for PDE2A;jsessionid=D48FF50AAD8C6217B6EEC6AE7E0087E0;jsessionid=5DCDE8D659E0594F8A3191B6CAC3EC1F (gene)

GO Molecular Function

guanyl ribonucleotide binding | cyclic nucleotide binding | cation binding | cAMP binding | ribonucleotide binding | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity | nucleotide binding | 3',5'-cyclic-AMP phosphodiesterase activity | hydrolase activity | carbohydrate derivative binding | cyclic-nucleotide phosphodiesterase activity | catalytic activity | protein domain specific binding | anion binding | adenyl nucleotide binding | cGMP binding | purine nucleotide binding | hydrolase activity, acting on ester bonds | identical protein binding | TPR domain binding | 3',5'-cyclic-GMP phosphodiesterase activity | ion binding | organic cyclic compound binding | protein binding | protein homodimerization activity | protein dimerization activity | phosphoric diester hydrolase activity | phosphoric ester hydrolase activity | purine ribonucleotide binding | GAF domain binding | adenyl ribonucleotide binding | drug binding | metal ion binding | heterocyclic compound binding | 3',5'-cyclic-nucleotide phosphodiesterase activity | guanyl nucleotide binding | small molecule binding

GO Biological Process

negative regulation of phosphorylation | purine ribonucleotide metabolic process | negative regulation of intracellular transport | regulation of intracellular protein transport | response to cytokine | nucleoside phosphate catabolic process | response to lipopolysaccharide | response to cGMP | regulation of cellular localization | intracellular signal transduction | endothelial cell development | regulation of localization | myeloid cell differentiation | negative regulation of cellular process | negative regulation of RNA biosynthetic process | regulation of protein import | cell differentiation | endothelial cell differentiation | response to drug | organophosphate catabolic process | regulation of organelle organization | response to organophosphorus | cellular process | organic substance catabolic process | cellular response to granulocyte macrophage colony-stimulating factor stimulus | nucleotide metabolic process | negative regulation of protein import into nucleus | negative regulation of signaling | response to hydrogen sulfide | carbohydrate derivative catabolic process | immune system development | ribose phosphate metabolic process | negative regulation of nucleic acid-templated transcription | response to growth factor | ribonucleotide metabolic process | response to inorganic substance | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | tissue development | regulation of oxidative phosphorylation | regulation of cellular process | cellular response to lipid | regulation of metabolic process | catabolic process | cellular response to molecule of bacterial origin | organic cyclic compound metabolic process | epithelium development | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | negative regulation of nucleotide metabolic process | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | negative regulation of protein localization to nucleus | response to transforming growth factor beta | response to stimulus | negative regulation of protein transport | vasculature development | purine nucleotide metabolic process | regulation of cellular protein localization | cellular response to mechanical stimulus | cellular response to xenobiotic stimulus | negative regulation of intracellular protein transport | cellular nitrogen compound biosynthetic process | epithelial cell development | cardiovascular system development | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | negative regulation of transport | cellular response to organic cyclic compound | regulation of protein transport | blood circulation | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | hemopoiesis | regulation of peptide transport | cellular biosynthetic process | nucleobase-containing compound catabolic process | regulation of intracellular transport | blood vessel development | regulation of nucleic acid-templated transcription | leukocyte differentiation | response to nitrogen compound | response to external biotic stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | endothelium development | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of ATP metabolic process | cGMP-mediated signaling | phosphorus metabolic process | response to purine-containing compound | response to granulocyte macrophage colony-stimulating factor | positive regulation of inflammatory response | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | cellular response to 2,3,7,8-tetrachlorodibenzodioxine | cyclic nucleotide metabolic process | regulation of phosphorylation | negative regulation of cellular protein localization | monocyte differentiation | artery development | regulation of gene expression | response to lipid | myeloid leukocyte differentiation | organophosphate metabolic process | coronary vasculature development | regulation of protein import into nucleus, translocation | establishment of endothelial barrier | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | small molecule metabolic process | regulation of vascular permeability | cGMP metabolic process | regulation of transcription by RNA polymerase II | cAMP catabolic process | nucleobase-containing small molecule metabolic process | second-messenger-mediated signaling | cellular response to cytokine stimulus | biosynthetic process | aromatic compound biosynthetic process | nucleotide catabolic process | response to toxic substance | response to xenobiotic stimulus | phosphate-containing compound metabolic process | cellular response to drug | regulation of mitochondrion organization | response to bacterium | cell communication | regulation of cellular metabolic process | negative regulation of oxidative phosphorylation | cyclic-nucleotide-mediated signaling | aromatic compound catabolic process | regulation of cAMP-mediated signaling | heart development | regulation of RNA metabolic process | regulation of nucleocytoplasmic transport | cellular response to transforming growth factor beta stimulus | cyclic nucleotide catabolic process | cAMP metabolic process | heart valve development | ventricular septum development | regulation of establishment of protein localization | cardiac ventricle development | response to organic substance | cGMP catabolic process | regulation of protein import into nucleus | cAMP-mediated signaling | response to mechanical stimulus | negative regulation of protein import into nucleus, translocation | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | positive regulation of vascular permeability | anatomical structure development | aorta development | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | cellular response to cGMP | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | cellular response to cAMP | regulation of ATP metabolic process | regulation of phosphate metabolic process | negative regulation of vascular permeability | response to cAMP | organonitrogen compound catabolic process | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | cell development | response to biotic stimulus | developmental process | negative regulation of cAMP-mediated signaling | cardiac septum development | negative regulation of transcription by RNA polymerase II | carbohydrate derivative metabolic process | regulation of transport | response to organonitrogen compound | epithelial cell differentiation | cardiac chamber development | heterocycle metabolic process | regulation of generation of precursor metabolites and energy | positive regulation of metabolic process | cellular response to macrophage colony-stimulating factor stimulus | regulation of nitric oxide mediated signal transduction | purine ribonucleotide catabolic process | response to 2,3,7,8-tetrachlorodibenzodioxine | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of protein localization | regulation of cell death | negative regulation of cell death | circulatory system development | regulation of inflammatory response | regulation of cellular component organization | response to other organism | signal transduction | regulation of signaling | positive regulation of gene expression | purine nucleotide catabolic process | cellular response to growth factor stimulus | cellular response to lipopolysaccharide | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

presynaptic membrane | mitochondrial matrix | organelle inner membrane | dendrite | intracellular membrane-bounded organelle | synapse | mitochondrial inner membrane | neuron projection | somatodendritic compartment | organelle membrane | cell | organelle outer membrane | synaptic membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | membrane microdomain | dendritic tree | presynapse | Golgi apparatus | cell projection | endomembrane system | plasma membrane | membrane raft | perinuclear region of cytoplasm | hippocampal mossy fiber | mitochondrion | dentate gyrus mossy fiber | membrane-bounded organelle | nucleus | organelle | mitochondrial outer membrane | mitochondrial envelope | cell periphery | axon | membrane-enclosed lumen | outer membrane | mitochondrial membrane | cytosol | intracellular | membrane

PATHWAYS

REACTOME_SIGNALING_BY_GPCR | REACTOME_GPCR_DOWNSTREAM_SIGNALING | REACTOME_G_ALPHA_S_SIGNALLING_EVENTS | REACTOME_CGMP_EFFECTS | REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE | REACTOME_PLATELET_HOMEOSTASIS | REACTOME_HEMOSTASIS

PROTEIN FAMILY

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | GAF domain | HD/PDEase domain | 3'5'-cyclic nucleotide phosphodiesterase | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | GAF-like domain superfamily | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily