QuickView for PDE3A;jsessionid=79C4C085F9CA08C4A9A41765A18C096D;jsessionid=6A4985F6708C280B18EF32440C11A880;jsessionid=38AAD53B24A32E26ADA5A577E7FA6492;jsessionid=FF98FE871F4BCC395D281361DEED21BA (gene)

Gene Symbol:

PDE3A Homo sapiens

Full name:

phosphodiesterase 3A

Synonyms:

CGI-PDE, CGI-PDE A, CGI-PDE-A, HTNB, cGMP-inhibited 3',5'-cyclic phosphodiesterase A, cAMP phosphodiesterase, myocardial cGMP-inhibited, cyclic GMP-inhibited phosphodiesterase A, phosphodiesterase 3A, cGMP-inhibited

Genomic Location:

Chr 12: 20413464-20725148

Description:

This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays ...

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This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGTG_MIR128A_MIR128B ,  ACTGTAG_MIR139 ,  RYTTCCTG_ETS2_B ,  ACTGTGA_MIR27A_MIR27B ,  CATGTAA_MIR496 ,  CAGGTG_E12_Q6 ,  CACCAGC_MIR138 ,  AP4_Q6 ,  AP4_01 ,  CAGCTG_AP4_Q5 ,  AP4_Q5

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-139 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

12p12.2

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