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QuickView for PDE4B;jsessionid=16BA33D194091596FBEEAE45E78F7A6A;jsessionid=468B4BFDEE6357D96E60304308247E73;jsessionid=8ABAD8E57969277BE736476461A92080;jsessionid=79B972D9795F53A5DEECDFF0703F486C (gene)


Gene Symbol:
PDE4B Homo sapiens Homo sapiens
Full name:
phosphodiesterase 4B
Synonyms:
DPDE4, PDEIVB, cAMP-specific 3',5'-cyclic phosphodiesterase 4B, dunce-like phosphodiesterase E4, phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
Genomic Location:
Chr 1: 66030781-66612850
Description:
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Al...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 1
1p31.3





GO Molecular Function

cyclic nucleotide binding | cation binding | cAMP binding | ribonucleotide binding | nucleotide binding | 3',5'-cyclic-AMP phosphodiesterase activity | hydrolase activity | carbohydrate derivative binding | cyclic-nucleotide phosphodiesterase activity | catalytic activity | ion channel binding | cytoskeletal protein binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | hydrolase activity, acting on ester bonds | ion binding | organic cyclic compound binding | protein binding | phosphoric diester hydrolase activity | phosphoric ester hydrolase activity | purine ribonucleotide binding | tubulin binding | adenyl ribonucleotide binding | gamma-tubulin binding | metal ion binding | heterocyclic compound binding | 3',5'-cyclic-nucleotide phosphodiesterase activity | small molecule binding

GO Biological Process

positive regulation of immune response | leukocyte homeostasis | purine ribonucleotide metabolic process | regulation of muscle system process | cell motility | immune response-regulating signaling pathway | nucleoside phosphate catabolic process | response to lipopolysaccharide | regulation of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | neutrophil homeostasis | immune response-activating cell surface receptor signaling pathway | T cell receptor signaling pathway | response to drug | organophosphate catabolic process | cellular response to epinephrine stimulus | cellular process | organic substance catabolic process | localization | nucleotide metabolic process | carbohydrate derivative catabolic process | negative regulation of relaxation of muscle | ribose phosphate metabolic process | ribonucleotide metabolic process | granulocyte chemotaxis | regulation of immune response | regulation of cellular process | cellular response to lipid | catabolic process | regulation of relaxation of muscle | cellular response to molecule of bacterial origin | positive regulation of interferon-gamma production | organic cyclic compound metabolic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | response to stimulus | purine nucleotide metabolic process | neutrophil chemotaxis | positive regulation of immune system process | cellular nitrogen compound biosynthetic process | regulation of blood circulation | regulation of cardiac muscle cell contraction | regulation of high voltage-gated calcium channel activity | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | immune response-activating signal transduction | cellular response to organic cyclic compound | G-protein coupled receptor signaling pathway | cellular biosynthetic process | nucleobase-containing compound catabolic process | cell chemotaxis | myeloid cell homeostasis | leukocyte migration | locomotion | response to nitrogen compound | response to external biotic stimulus | nitrogen compound metabolic process | cell migration | phosphorus metabolic process | regulation of muscle contraction | cyclic nucleotide metabolic process | response to lipid | response to epinephrine | organophosphate metabolic process | small molecule metabolic process | regulation of cellular component movement | negative regulation of relaxation of cardiac muscle | cAMP catabolic process | nucleobase-containing small molecule metabolic process | homeostasis of number of cells | biosynthetic process | aromatic compound biosynthetic process | regulation of calcium ion transmembrane transport | nucleotide catabolic process | regulation of voltage-gated calcium channel activity | regulation of heart contraction | phosphate-containing compound metabolic process | cellular response to drug | regulation of striated muscle contraction | response to bacterium | regulation of relaxation of cardiac muscle | cell communication | response to catecholamine | regulation of cardiac muscle contraction | aromatic compound catabolic process | leukocyte chemotaxis | homeostatic process | cyclic nucleotide catabolic process | cAMP metabolic process | response to monoamine | activation of immune response | response to organic substance | cell surface receptor signaling pathway | metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | regulation of ion transmembrane transport | antigen receptor-mediated signaling pathway | positive regulation of cytokine production | organonitrogen compound catabolic process | signaling | response to organic cyclic compound | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | regulation of cytokine production | response to biotic stimulus | regulation of ion transport | regulation of calcium ion transport | positive regulation of interleukin-2 production | carbohydrate derivative metabolic process | regulation of transport | regulation of cation channel activity | response to organonitrogen compound | heterocycle metabolic process | regulation of actin filament-based process | regulation of calcium ion transmembrane transporter activity | purine ribonucleotide catabolic process | regulation of interferon-gamma production | immune system process | cellular metabolic process | cellular response to organic substance | neutrophil migration | chemotaxis | response to other organism | cellular response to catecholamine stimulus | signal transduction | purine nucleotide catabolic process | cellular response to lipopolysaccharide

GO Cellular Component

supramolecular fiber | dendritic spine | exocytic vesicle | integral component of membrane | dendrite | synapse | neuron projection | somatodendritic compartment | sarcomere | microtubule organizing center | cytoplasmic vesicle | voltage-gated calcium channel complex | cell | plasma membrane protein complex | intrinsic component of membrane | myofibril | cytoplasm | intracellular organelle | dendritic tree | contractile fiber | presynapse | centrosome | protein-containing complex | cell projection | secretory vesicle | endomembrane system | neuron spine | postsynapse | plasma membrane | vesicle | transport vesicle | postsynaptic density | microtubule cytoskeleton | asymmetric synapse | synaptic vesicle | calcium channel complex | gamma-tubulin complex | membrane-bounded organelle | organelle | postsynaptic specialization | I band | cell periphery | excitatory synapse | transmembrane transporter complex | cation channel complex | ion channel complex | Z disc | cytosol | intracellular vesicle | cytoskeleton | intracellular | membrane | supramolecular complex