QuickView for PDE4B;jsessionid=16BA33D194091596FBEEAE45E78F7A6A;jsessionid=A5A805596B827A410492A65FDFA973B6;jsessionid=806AA4F93F143019DCBE8536D7BE0CDF;jsessionid=F01C9501E867EEE13190187659CDA34F (gene)
- Gene Symbol:
- Pde4b
Rattus norvegicus - Full name:
- phosphodiesterase 4B
- Synonyms:
- PDE4/IVb, Pde4B1, Pde4B2, Pde4B3, Pde4B4, Pde4b5, cAMP-specific 3',5'-cyclic phosphodiesterase 4B, 3',5'-cyclic AMP phosphodiesterase, DPDE4, Phosphodiesterase 4B, cAMP-specific (dunce, phosphodiesterase 4B, cAMP specific, phosphodiesterase type 4B5
- Genomic Location:
- Chr 5: 123158158-123533877
- Description:
-
contains four isoforms expressed from the same gene; isoform Pde4b4 has cAMP specific phosphdiesterase activity and is inhibited by rolipram
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
cyclic nucleotide binding | cation binding | cAMP binding | ribonucleotide binding | nucleotide binding | 3',5'-cyclic-AMP phosphodiesterase activity | hydrolase activity | carbohydrate derivative binding | cyclic-nucleotide phosphodiesterase activity | catalytic activity | ion channel binding | cytoskeletal protein binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | hydrolase activity, acting on ester bonds | ion binding | organic cyclic compound binding | protein binding | phosphoric diester hydrolase activity | phosphoric ester hydrolase activity | purine ribonucleotide binding | tubulin binding | adenyl ribonucleotide binding | gamma-tubulin binding | metal ion binding | heterocyclic compound binding | 3',5'-cyclic-nucleotide phosphodiesterase activity | small molecule binding
GO Biological Process
positive regulation of immune response | leukocyte homeostasis | negative regulation of G-protein coupled receptor protein signaling pathway | purine ribonucleotide metabolic process | regulation of muscle system process | cell motility | immune response-regulating signaling pathway | nucleoside phosphate catabolic process | response to lipopolysaccharide | regulation of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | neutrophil homeostasis | negative regulation of cellular process | immune response-activating cell surface receptor signaling pathway | T cell receptor signaling pathway | response to drug | organophosphate catabolic process | cellular response to epinephrine stimulus | cellular process | organic substance catabolic process | localization | nucleotide metabolic process | negative regulation of signaling | carbohydrate derivative catabolic process | negative regulation of relaxation of muscle | ribose phosphate metabolic process | ribonucleotide metabolic process | granulocyte chemotaxis | regulation of immune response | regulation of cellular process | cellular response to lipid | catabolic process | regulation of relaxation of muscle | cellular response to molecule of bacterial origin | positive regulation of interferon-gamma production | organic cyclic compound metabolic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | smooth muscle contraction | muscle contraction | response to stimulus | purine nucleotide metabolic process | neutrophil chemotaxis | positive regulation of immune system process | cellular nitrogen compound biosynthetic process | regulation of blood circulation | regulation of cardiac muscle cell contraction | regulation of high voltage-gated calcium channel activity | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway | immune response-activating signal transduction | cellular response to organic cyclic compound | cellular biosynthetic process | nucleobase-containing compound catabolic process | cell chemotaxis | myeloid cell homeostasis | leukocyte migration | locomotion | response to nitrogen compound | response to external biotic stimulus | nitrogen compound metabolic process | regulation of signal transduction | cell migration | phosphorus metabolic process | regulation of muscle contraction | cyclic nucleotide metabolic process | response to lipid | response to epinephrine | organophosphate metabolic process | negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process | small molecule metabolic process | regulation of cellular component movement | negative regulation of relaxation of cardiac muscle | cAMP catabolic process | nucleobase-containing small molecule metabolic process | homeostasis of number of cells | biosynthetic process | aromatic compound biosynthetic process | regulation of calcium ion transmembrane transport | nucleotide catabolic process | regulation of voltage-gated calcium channel activity | regulation of heart contraction | phosphate-containing compound metabolic process | cellular response to drug | regulation of striated muscle contraction | response to bacterium | regulation of relaxation of cardiac muscle | cell communication | response to catecholamine | regulation of cardiac muscle contraction | aromatic compound catabolic process | regulation of cAMP-mediated signaling | leukocyte chemotaxis | homeostatic process | cyclic nucleotide catabolic process | cAMP metabolic process | response to monoamine | activation of immune response | response to organic substance | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cell surface receptor signaling pathway | metabolic process | negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway | nucleobase-containing compound metabolic process | organic substance metabolic process | regulation of ion transmembrane transport | antigen receptor-mediated signaling pathway | positive regulation of cytokine production | organonitrogen compound catabolic process | regulation of cell communication | negative regulation of signal transduction | signaling | response to organic cyclic compound | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | regulation of cytokine production | response to biotic stimulus | regulation of ion transport | regulation of G-protein coupled receptor protein signaling pathway | negative regulation of cAMP-mediated signaling | regulation of calcium ion transport | positive regulation of interleukin-2 production | carbohydrate derivative metabolic process | regulation of transport | regulation of cation channel activity | response to organonitrogen compound | heterocycle metabolic process | regulation of actin filament-based process | regulation of calcium ion transmembrane transporter activity | purine ribonucleotide catabolic process | regulation of interferon-gamma production | immune system process | cellular metabolic process | cellular response to organic substance | neutrophil migration | chemotaxis | muscle system process | response to other organism | cellular response to catecholamine stimulus | signal transduction | regulation of signaling | purine nucleotide catabolic process | cellular response to lipopolysaccharide | multicellular organismal process
GO Cellular Component
supramolecular fiber | dendritic spine | exocytic vesicle | integral component of membrane | dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | somatodendritic compartment | sarcomere | microtubule organizing center | cytoplasmic vesicle | voltage-gated calcium channel complex | cell | plasma membrane protein complex | intrinsic component of membrane | myofibril | cytoplasm | intracellular organelle | dendritic tree | contractile fiber | presynapse | centrosome | protein-containing complex | cell projection | secretory vesicle | endomembrane system | neuron spine | postsynapse | plasma membrane | vesicle | transport vesicle | perinuclear region of cytoplasm | postsynaptic density | microtubule cytoskeleton | asymmetric synapse | synaptic vesicle | calcium channel complex | gamma-tubulin complex | membrane-bounded organelle | nucleus | organelle | postsynaptic specialization | I band | cell periphery | excitatory synapse | transmembrane transporter complex | cation channel complex | ion channel complex | Z disc | cytosol | intracellular vesicle | cytoskeleton | intracellular | membrane | supramolecular complex
