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QuickView for PDE5A;jsessionid=1CF83982C7D912C10DA1502CD79F7471;jsessionid=E0C4FE0977B128BB3AFF51AC37BC6127;jsessionid=358B6B7B02B508A27525E9EA83A231C1;jsessionid=01273EEDAAC211FE5D24EF85BF678D7B;jsessionid=5383CB3772CFC06FED33AD27B5AC04C8;jsessionid=5259189ED3B63CA94E2162761D9B8D63 (gene)


Gene Symbol:
Pde5a Rattus norvegicus Rattus norvegicus
Full name:
phosphodiesterase 5A
Synonyms:
PDE5A2, cGMP-specific 3',5'-cyclic phosphodiesterase, CGB-PDE, cGMP-binding cGMP specific phosphodiesterase 5A2, cGMP-binding cGMP-specific phosphodiesterase, phosphodiesterase 5A, cGMP-specific, phosphodiesterase type 5
Genomic Location:
Chr 2: 219410394-219550910
Description:
catalyzes the hydrolysis of cGMP to 5'-GMP; may regulate vascular relaxation; may be involved in establishment of cerebellar neural networks
Orthologs:
Homo sapiens Mus musculus D. melanogaster Macaca mulatta Bos taurus Canis lupus familiaris Gallus gallus Pan troglodytes Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):


Protein Names
O54735



GO Molecular Function

guanyl ribonucleotide binding | cyclic nucleotide binding | cation binding | ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | cyclic-nucleotide phosphodiesterase activity | catalytic activity | anion binding | cGMP binding | purine nucleotide binding | hydrolase activity, acting on ester bonds | 3',5'-cyclic-GMP phosphodiesterase activity | ion binding | organic cyclic compound binding | phosphoric diester hydrolase activity | phosphoric ester hydrolase activity | purine ribonucleotide binding | metal ion binding | heterocyclic compound binding | 3',5'-cyclic-nucleotide phosphodiesterase activity | guanyl nucleotide binding | small molecule binding

GO Biological Process

negative regulation of leukocyte activation | purine ribonucleotide metabolic process | regulation of blood vessel diameter | regulation of muscle system process | negative regulation of immune system process | positive regulation of blood circulation | nucleoside phosphate catabolic process | response to lipopolysaccharide | negative regulation of muscle contraction | positive regulation of apoptotic process | regulation of cell development | regulation of programmed cell death | regulation of oogenesis | regulation of immune system process | response to hormone | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | positive regulation of developmental process | regulation of MAP kinase activity | nervous system development | organophosphate catabolic process | relaxation of cardiac muscle | positive regulation of phosphate metabolic process | regulation of oocyte development | cellular process | organic substance catabolic process | nucleotide metabolic process | carbohydrate derivative catabolic process | ribose phosphate metabolic process | positive regulation of protein kinase activity | response to hypoxia | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | ribonucleotide metabolic process | negative regulation of T cell proliferation | regulation of cell differentiation | positive regulation of cardiac muscle hypertrophy | positive regulation of vasoconstriction | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | negative regulation of mononuclear cell proliferation | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | cellular aromatic compound metabolic process | positive regulation of oogenesis | response to stimulus | purine nucleotide metabolic process | positive regulation of protein metabolic process | negative regulation of cell adhesion | regulation of blood vessel size | response to stress | negative regulation of lymphocyte activation | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | regulation of blood circulation | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | negative regulation of cardiac muscle contraction | blood circulation | positive regulation of protein serine/threonine kinase activity | regulation of cell adhesion | cellular biosynthetic process | nucleobase-containing compound catabolic process | response to external biotic stimulus | system development | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | regulation of MAPK cascade | phosphorus metabolic process | positive regulation of inflammatory response | learning or memory | relaxation of muscle | regulation of muscle contraction | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | cyclic nucleotide metabolic process | regulation of phosphorylation | regulation of T cell activation | response to ketone | response to lipid | nervous system process | organophosphate metabolic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | small molecule metabolic process | positive regulation of intracellular signal transduction | cGMP metabolic process | regulation of the force of heart contraction | positive regulation of cell differentiation | nucleobase-containing small molecule metabolic process | cognition | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | nucleotide catabolic process | regulation of heart contraction | phosphate-containing compound metabolic process | regulation of striated muscle contraction | response to bacterium | negative regulation of cell-cell adhesion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | response to testosterone | short-term memory | negative regulation of cell activation | regulation of cardiac muscle contraction | regulation of protein metabolic process | positive regulation of signal transduction | aromatic compound catabolic process | regulation of protein phosphorylation | regulation of tube size | positive regulation of molecular function | cyclic nucleotide catabolic process | regulation of cardiac muscle hypertrophy | positive regulation of protein modification process | response to organic substance | cGMP catabolic process | regulation of kinase activity | regulation of intracellular signal transduction | anatomical structure development | regulation of vasoconstriction | vasodilation | regulation of chronic inflammatory response | metabolic process | positive regulation of cell development | negative regulation of leukocyte proliferation | regulation of tube diameter | negative regulation of heart contraction | behavior | positive regulation of cell death | nucleobase-containing compound metabolic process | organic substance metabolic process | regulation of cell activation | positive regulation of programmed cell death | positive regulation of kinase activity | regulation of phosphate metabolic process | positive regulation of MAPK cascade | memory | positive regulation of chronic inflammatory response | organonitrogen compound catabolic process | regulation of cell communication | signaling | response to organic cyclic compound | regulation of T cell proliferation | positive regulation of phosphorylation | positive regulation of MAP kinase activity | response to biotic stimulus | regulation of developmental process | developmental process | carbohydrate derivative metabolic process | negative regulation of cell proliferation | regulation of cell-cell adhesion | heterocycle metabolic process | positive regulation of metabolic process | regulation of nitric oxide mediated signal transduction | purine ribonucleotide catabolic process | negative regulation of lymphocyte proliferation | cellular metabolic process | positive regulation of oocyte development | regulation of cell death | negative regulation of striated muscle contraction | positive regulation of blood vessel diameter | regulation of inflammatory response | muscle system process | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | purine nucleotide catabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

cell | cytoplasm | cytosol | intracellular