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QuickView for PDE5A;jsessionid=1CF83982C7D912C10DA1502CD79F7471;jsessionid=E0C4FE0977B128BB3AFF51AC37BC6127;jsessionid=358B6B7B02B508A27525E9EA83A231C1;jsessionid=A008B77CF74A5DBB31DFED4A61813D10;jsessionid=482CB414FEE4C4C486463398C4BC38C4;jsessionid=4CDA1858481419840BD091B6761D2E6D (gene)


Gene Symbol:
PDE5A Homo sapiens Homo sapiens
Full name:
phosphodiesterase 5A
Synonyms:
CGB-PDE, CN5A, PDE5, cGMP-specific 3',5'-cyclic phosphodiesterase, cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase, cGMP-specific phosphodiesterase PDE5A2, cGMP-specific phosphodiesterase type 5A, phosphodiesterase 5A, cGMP-specific, phosphodiesterase isozyme 5
Genomic Location:
Chr 4: 120634998-120769429
Description:
This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular syste...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Bos taurus Canis lupus familiaris Gallus gallus Pan troglodytes Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 4
4q26





GO Molecular Function

guanyl ribonucleotide binding | cyclic nucleotide binding | cation binding | ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | cyclic-nucleotide phosphodiesterase activity | catalytic activity | anion binding | cGMP binding | purine nucleotide binding | hydrolase activity, acting on ester bonds | 3',5'-cyclic-GMP phosphodiesterase activity | ion binding | organic cyclic compound binding | protein binding | phosphoric diester hydrolase activity | phosphoric ester hydrolase activity | purine ribonucleotide binding | metal ion binding | heterocyclic compound binding | 3',5'-cyclic-nucleotide phosphodiesterase activity | guanyl nucleotide binding | small molecule binding

GO Biological Process

negative regulation of leukocyte activation | purine ribonucleotide metabolic process | regulation of muscle system process | negative regulation of immune system process | nucleoside phosphate catabolic process | negative regulation of muscle contraction | regulation of cell development | regulation of oogenesis | regulation of immune system process | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | positive regulation of developmental process | regulation of MAP kinase activity | organophosphate catabolic process | relaxation of cardiac muscle | positive regulation of phosphate metabolic process | regulation of oocyte development | cellular process | organic substance catabolic process | nucleotide metabolic process | carbohydrate derivative catabolic process | ribose phosphate metabolic process | positive regulation of protein kinase activity | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | ribonucleotide metabolic process | negative regulation of T cell proliferation | regulation of cell differentiation | positive regulation of cardiac muscle hypertrophy | regulation of cellular process | regulation of metabolic process | catabolic process | negative regulation of mononuclear cell proliferation | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | cellular aromatic compound metabolic process | positive regulation of oogenesis | response to stimulus | purine nucleotide metabolic process | positive regulation of protein metabolic process | negative regulation of cell adhesion | negative regulation of lymphocyte activation | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | regulation of blood circulation | cellular nitrogen compound metabolic process | negative regulation of cardiac muscle contraction | positive regulation of protein serine/threonine kinase activity | regulation of cell adhesion | cellular biosynthetic process | nucleobase-containing compound catabolic process | nitrogen compound metabolic process | regulation of signal transduction | regulation of MAPK cascade | phosphorus metabolic process | relaxation of muscle | regulation of muscle contraction | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | cyclic nucleotide metabolic process | regulation of phosphorylation | regulation of T cell activation | organophosphate metabolic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | small molecule metabolic process | positive regulation of intracellular signal transduction | cGMP metabolic process | positive regulation of cell differentiation | nucleobase-containing small molecule metabolic process | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | nucleotide catabolic process | regulation of heart contraction | phosphate-containing compound metabolic process | regulation of striated muscle contraction | negative regulation of cell-cell adhesion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | negative regulation of cell activation | regulation of cardiac muscle contraction | regulation of protein metabolic process | positive regulation of signal transduction | aromatic compound catabolic process | regulation of protein phosphorylation | positive regulation of molecular function | cyclic nucleotide catabolic process | regulation of cardiac muscle hypertrophy | positive regulation of protein modification process | cGMP catabolic process | regulation of kinase activity | regulation of intracellular signal transduction | metabolic process | positive regulation of cell development | negative regulation of leukocyte proliferation | negative regulation of heart contraction | nucleobase-containing compound metabolic process | organic substance metabolic process | regulation of cell activation | positive regulation of kinase activity | regulation of phosphate metabolic process | positive regulation of MAPK cascade | organonitrogen compound catabolic process | regulation of cell communication | signaling | regulation of T cell proliferation | positive regulation of phosphorylation | positive regulation of MAP kinase activity | regulation of developmental process | carbohydrate derivative metabolic process | negative regulation of cell proliferation | regulation of cell-cell adhesion | heterocycle metabolic process | positive regulation of metabolic process | regulation of nitric oxide mediated signal transduction | purine ribonucleotide catabolic process | negative regulation of lymphocyte proliferation | cellular metabolic process | positive regulation of oocyte development | negative regulation of striated muscle contraction | muscle system process | positive regulation of signaling | signal transduction | regulation of signaling | purine nucleotide catabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

cell | cytoplasm | cytosol | intracellular